Burden of cancer associated with type 2 diabetes mellitus in Japan

• Project/Area Number: 25460742
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: The University of Tokyo
• Principal Investigator: INOUE Manami 東京大学, 医学(系)研究科(研究院), 特任教授 (70250248)
• Co-Investigator(Kenkyū-buntansha): SASAZUKI Shizuka 国立がん研究センター, 社会と健康研究センター, 部長 (50392337) ; MATSUDA Tomohiro 国立がん研究センター, がん対策情報センター, 室長 (60370954) ; NODA Mitsuhiko 国立国際医療研究センター, 糖尿病研究部, 部長 (90237850)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2015: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: 人口寄与割合 / 糖尿病 / がん / 相対危険度 / 保有率

Outline of Final Research Achievements

We aimed to estimate the burden of cancer associated with type 2 diabetes mellitus (T2DM) in Japan. We first estimated trends of T2DM prevalence. In the present meta-regression analysis of studies and national surveys between 1988 and 2011 in Japan, prevalence appeared to remain unchanged over the years in all age categories except for men aged 70 years or older. Age-standardized T2DM prevalence was 9.9% among men, 6.1% among women and 7.9% among the total population in 2010. Second, we estimated the burden of cancer risk associated with T2DM in 2010 and 2030. The number of excess incident cancer cases associated with T2DM, an increase of 26.5% in men and 53.2% in women is expected between 2010 and 2030. The attributable fraction of cancer risk associated with T2DM was 1.4% in 2010 and 1.7% in 2030. The burden of cancer will increase in adults aged 60+ years over time, but will not change in adults aged 20-59 years.

Research Products

• [Journal Article] Burden of cancer associated with type 2 diabetes mellitus in Japan, 2010–2030. (2016)
  • Author(s): Saito E, Charvat H, Goto A, Matsuda T, Noda M, Sasazuki S, Inoue M.
  • Journal Title: Cancer Sci Volume: 印刷中 Issue: 4 Pages: 521-527
  • DOI: 10.1111/cas.12902
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Impact of population aging on trends in diabetes prevalence: A meta-regression analysis of 160,000 Japanese adults (2015)
  • Author(s): Charvat H, Goto A, Goto M, Inoue M, Heianza Y, Arase Y, Sone H, Nakagami T, Song X, Qiao Q, Tuomilehto J, Tsugane S, Noda M, Inoue M.
  • Journal Title: Journal of Diabetes Investigation Volume: 印刷中 Issue: 5 Pages: 533-542
  • DOI: 10.1111/jdi.12333
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Diabetes and Cancer - the fraction of cancer attributable to diabetes in Japan: current status and future prospects (2015)
  • Author(s): 井上真奈美
  • Organizer: 日本癌学会
  • Place of Presentation: Nagoya Congress Center（愛知県名古屋市）
  • Year and Date: 2015-10-08
  • Invited
• [Presentation] 糖尿病とがんの疫学研究 (2015)
  • Author(s): 井上 真奈美
  • Organizer: 第49回 糖尿病の進歩
  • Place of Presentation: 岡山シティミュージアム（岡山県岡山市）
  • Year and Date: 2015-02-21
  • Invited
• [Presentation] 糖尿病とがん：世界と日本のエビデンス (2014)
  • Author(s): 井上 真奈美
  • Organizer: がん予防学術大会2014東京
  • Place of Presentation: 国立がん研究センター国際交流会館（東京都中央区）
  • Year and Date: 2014-06-13
  • Invited