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Association of obesity indexes with metaboric risk factors

Research Project

Project/Area Number 25460749
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Epidemiology and preventive medicine
Research InstitutionKyoto University

Principal Investigator

Yasuno Shinji  京都大学, 医学研究科, 特定助教 (20467476)

Co-Investigator(Kenkyū-buntansha) 宮脇 尚志  京都女子大学, 家政学部, 教授 (10422966)
大庭 幸治  東京大学, 医学研究科, 准教授 (30422926)
Co-Investigator(Renkei-kenkyūsha) Ueshima Kenji  京都大学, 医学研究科, 教授 (40213334)
Research Collaborator Sato Keiko  京都大学, 医学研究科, 特任准教授
Kuwabara Yoshihiro  京都大学, 医学研究科, 研究員
Konda Manako  京都大学, 医学研究科, 研究員
Masuda Izuru  康生会武田病院健診センター, 所長
Tamaki Shunichi  山科武田ラクト健診センター, 所長
Kanachi Kenji  洛和会東寺南病院, 院長
Nisjikawa Hiroyuki  洛和会東寺南病院, 健診センター, 係長
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords肥満 / メタボリック症候群 / 体格指数 / 腹囲 / 内臓脂肪面積 / 皮下脂肪面積 / 生活習慣病 / 観察研究
Outline of Final Research Achievements

We evaluated the associations between obesity indexes, including BMI, waist circumstance, visceral fat area (VFA), and subcutaneous fat area (SFA), and the percentages of participants having metabolic syndrome (Mets) components, including high blood pressure, dyslipidemia, high blood sugar, in the individual who underwent medical check-up. In both men and woman, the percentages increased with increase of each obesity index. When we looked at the associations between the percentages and obesity index considering both VFA and SFA, we observed the strong association of them with increased VFA in men. On the other hand, they were associated with not only increased VFA but also increased SFA in women. The present study suggests that both VFA and SFA are involved in the pathogenesis of metabolic disturbance in woman.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (28 results)

All 2016 2015 2014 2013 Other

All Journal Article (14 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 14 results,  Open Access: 3 results) Presentation (12 results) (of which Int'l Joint Research: 1 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Optimal timing of surgery for active infective endocarditis with cerebral complications: a Japanese multicentre study.2016

    • Author(s)
      Okita Y, Minakata K, Yasuno S, Uozumi R, Sato T, Ueshima K, Konishi H, Morita N, Harada M, Kobayashi J, Suehiro S, Kawahito K, Okabayashi H, Takanashi S, Ueda Y, Usui A, Imoto K, Tanaka H, Okamura Y, Sakata R, Yaku H, Tanemoto K, Imoto Y, Hashimoto K, Bando K
    • Journal Title

      Eur J Cardiothorac Surg

      Volume: 未確定

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Differential Relationships Between Anemia and Outcome in Subgroups of Patients With Chronic Heart Failure2015

    • Author(s)
      Nakagawa Y, Yasuno S, Kuwahara K
    • Journal Title

      Circulation Journal

      Volume: 79 Issue: 9 Pages: 1893-1894

    • DOI

      10.1253/circj.CJ-15-0852

    • NAID

      130005095294

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Holter monitoring for the screening of cardiac disease in diabetes mellitus: The non-invasive Holter monitoring observation of new cardiac events in diabetics study.2015

    • Author(s)
      Nakao YM, Ueshima K, Nohara R, Mizunuma Y, Segawa I, Tanaka-Mizuno S, Yasuno S, Nakao K, Hiramori K, Kihara Y.
    • Journal Title

      Diab Vasc Dis Res.

      Volume: 12(6) Issue: 6 Pages: 396-404

    • DOI

      10.1177/1479164115595523

    • NAID

      120005702803

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 内臓脂肪蓄積と生活習慣病及び食事内容との関連-人間ドック受診者を対象とした横断研究―2015

    • Author(s)
      兼定 祐里, 保野 慎治, 西河 浩之, 増田 陽子, 中塚かなゑ, 福永 康智, 齋籐 信雄, 五郎丸直美, 田巻 俊一, 桝田 出, 上嶋 健治, 宮脇 尚志
    • Journal Title

      日本臨床栄養学会雑誌

      Volume: 49 Pages: 130-141

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Outcomes of trastuzumab therapy in HER2-positive early breast cancer patients.2015

    • Author(s)
      Yamashiro H, Iwata H, Masuda N, Yamamoto N, Nishimura R, Ohtani S, Sato N, Takahashi M, Kamio T, Yamazaki K, Saito T, Kato M, Lee T, Ohno S, Kuroi K, Takano T, Takada M, Yasuno S, Morita S, Toi M.
    • Journal Title

      Int J Clin Oncol.

      Volume: Epub ahead of print

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of nocturnal oxygen therapy in patients with chronic heart failure and central sleep apnea: CHF-HOT study.2014

    • Author(s)
      Nakao YM, Ueshima K, Yasuno S, Sasayama S.
    • Journal Title

      Heart Vessels.

      Volume: Epub ahead of print

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inhibition of N-type Ca2+ channels ameliorates an imbalance in cardiac autonomic nerve activity and prevents lethal arrhythmias in mice with heart failure.2014

    • Author(s)
      Yamada Y, Kinoshita H, Kuwahara K, Nakagawa Y, Kuwabara Y, Minami T, Yamada C, Shibata J, Nakao K, Cho K, Arai Y, Yasuno S, Nishikimi T, Ueshima K, Kamakura S, Nishida M, Kiyonaka S, Mori Y, Kimura T, Kangawa K, Nakao K.
    • Journal Title

      Cardiovasc Research

      Volume: 104 Issue: 1 Pages: 183-193

    • DOI

      10.1093/cvr/cvu185

    • NAID

      120005619790

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Preoperative chronic kidney disease as a strong predictor of postoperative infection and mortality after coronary artery bypass grafting.2014

    • Author(s)
      Minakata K, Bando K, Tanaka S, Takanashi S, Konishi H, Miyamoto Y, Ueshima K, Yasuno S, Ueda Y, Okita Y, Masuda I, Okabayashi H, Yaku H, Okamura Y, Tanemoto K, Arinaga K, Hisashi Y, Sakata R.
    • Journal Title

      Circ J

      Volume: 78 Pages: 2225-31

    • NAID

      130004677619

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] The effects of super-flux (high performance) dialyzer on plasma glycosylated pro-B-type natriuretic peptide (proBNP) and glycosylated N-Terminal proBNP in end-stage renal disease patients on dialysis.2014

    • Author(s)
      Nakagawa Y, Nishikimi T, Kuwahara K, Yasuno S, Kinoshita H, Kuwabara Y, Nakao K, Minami T, Yamada C, Ueshima K, Ikeda Y, Okamoto H, Horii K, Nagata K, Kangawa K, Minamino N, Nakao K.
    • Journal Title

      PLoS One

      Volume: 25 Issue: 3 Pages: e92314-e92314

    • DOI

      10.1371/journal.pone.0092314

    • NAID

      120007100132

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Predictive significance of kidney myeloid-related protein 8 expression in patients with obesity- or type 2 diabetes-associated kidney diseases2014

    • Author(s)
      Kuwabara T, Mori K, Kasahara M, Yokoi H, Imamaki H, Ishii A, Koga K, Sugawara A, Yasuno S, Ueshima K, Morikawa T, Konishi Y, Imanishi M, Nishiyama A, Nakao K, Mukoyama M
    • Journal Title

      PloS One

      Volume: 9 Issue: 2 Pages: e88942-e88942

    • DOI

      10.1371/journal.pone.0088942

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Do statins play a role in renoprotection?2014

    • Author(s)
      Kasahara M, Nakagawa T, Yokoi H, Kuwabara T, Yasuno S, Mori K, Mukoyama M, Ueshima K.
    • Journal Title

      Clin Exp Nephrol

      Volume: Epub ahead of print

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Angiotensin II type 1a receptor signalling directly contributes to the increased arrhythmogenicity in cardiac hypertrophy2013

    • Author(s)
      Yasuno, S., Kuwahara, K., Kinoshita, H., Yamada, C., Nakagawa, Y., Usami, S., Kuwabara, Y., Ueshima, K., Harada, M., Nishikimi, T., Nakao, K.
    • Journal Title

      British Journal of Pharmacology

      Volume: 170(7) Issue: 7 Pages: 1384-1395

    • DOI

      10.1111/bph.12328

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Adrenal reserve function after unilateral adrenalectomy in patients with primary aldosteronism.2013

    • Author(s)
      Honda K, Sone M, Tamura N, Sonoyama T, Taura D, Kojima K, Fukuda Y, Tanaka S, Yasuno S, Fujii T, Kinoshita H, Ariyasu H, Kanamoto N, Miura M, Yasoda A, Arai H, Ueshima K, Nakao K.
    • Journal Title

      J Hypertens

      Volume: 31 Issue: 10 Pages: 2010-7

    • DOI

      10.1097/hjh.0b013e3283635789

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Increased expression of HCN channels in the ventricular myocardium contributes to enhanced arrhythmicity in mouse failing hearts.2013

    • Author(s)
      Kuwabara, Y., Kuwahara, K., Takano, M., Kinoshita, H., Arai, Y., Yasuno, S., Nakagawa, Y., Igata, S., Usami, S., Minami, T., Yamada, Y., Nakao, K., Yamada, C., Shibata, J., Nishikimi, T., Ueshima, K., Nakao, K.
    • Journal Title

      Journal of the American Heart Association

      Volume: 2(3) Issue: 3

    • DOI

      10.1161/jaha.113.000150

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 健診後の生活指導の有無による体組成の変化2016

    • Author(s)
      五郎丸直美、桝田出、保野慎治、水口善夫、蓑毛佳代、須山哲次、田巻俊一、武田貞子、武田道子
    • Organizer
      日本人間ドック学会
    • Place of Presentation
      長野県松本市
    • Year and Date
      2016-07-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] Optimal timing of surgery for active infectious endocarditis with cerebral complications: Japanese multi-centre study.2015

    • Author(s)
      Okita Y, Minakata K, Yasuno S, Sato T, Ueshima K, Morita N, Harada M, Kobayashi J
    • Organizer
      the 29th Annual Meeting of the European Association for Cardio-Thoracic Surgery (EACTS)
    • Place of Presentation
      Amsterdam, Netherland
    • Year and Date
      2015-10-03
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] The direction of the ideal future clinical trials in our country.2015

    • Author(s)
      Kasahara M, Yasuno S, Kuwabara Y, Sato K, Ueshima K
    • Organizer
      第79回日本循環器学会
    • Place of Presentation
      大阪
    • Year and Date
      2015-04-24
    • Related Report
      2015 Research-status Report
  • [Presentation] Reduced Exercise Capacity Attributable to Latent Left Ventricular Diastolic Dysfunction Unmasked by Invasive Exercise Testing in Diabetic Patients After Acute Myocardial Infarction.2014

    • Author(s)
      Hieda M, Yasuno S, Nagaya N, Takaki H, Goto Y
    • Organizer
      American Heart Association Scientific Sessions 2014
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Research-status Report
  • [Presentation] Effects of Atorvastatin on Salt Sensitivity and Blood Pressure in Hypertensive Patients (DUET Study).2014

    • Author(s)
      Ishii A, Kasahara M, Yokoi H, Kuwabara T, Yasuno S, Mori K, Fujimoto A, Tanaka S, Satoh-Asahara N, Sakamoto T, Morii N, Horii K, Sakai T, Mukoyama M, Ueshima K
    • Organizer
      Kidney Week 2014
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2014-11-11 – 2014-11-16
    • Related Report
      2014 Research-status Report
  • [Presentation] Glomerular MRP8 expression predicts progression of proteinuria in obese or type 2 diabetic patients.2014

    • Author(s)
      Kuwabara T, Mori K, Yokoi H, Yasuno S, Kasahara M, Ueshima K, Nakao K, Imanishi M, Nishiyama A, Yanagita M, Mukoyama M
    • Organizer
      Kidney Week 2014
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2014-11-11 – 2014-11-16
    • Related Report
      2014 Research-status Report
  • [Presentation] Impact of chronic kidney disease and coronary heart disease on cardiovascular risks in high-risk hypertensive patients: a subanalysis of the CASE-J Ex.2014

    • Author(s)
      Yasuno S, Ueshima K, Tanaka S, Fujimoto A, Kasahara M, Ogihara T, Saruta T, Nakao K
    • Organizer
      European Society of Cardiology 2014
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2014-08-30 – 2014-09-03
    • Related Report
      2014 Research-status Report
  • [Presentation] Associations between blood pressure and new-onset of proteinuria in Japanese: MIYAKO (Multicenter Investigation for Yearly medical check Assessment in KyotO) surveillance.2014

    • Author(s)
      Yasuno S, Ueshima K, Oba K, Kasahara M, Fujimoto A, Nakao YM, Miyawaki T, Masuda I, Nakao K
    • Organizer
      Hypertension 2014
    • Place of Presentation
      Athens, Greece
    • Year and Date
      2014-06-13 – 2014-06-16
    • Related Report
      2014 Research-status Report
  • [Presentation] Effects of atorvastatin on renal function in patients with dyslipidemia and chronic kidney disease: Principal results of ASsessment of clinical Usefulness in CKD patients with Atorvastatin (ASUCA) trial.2013

    • Author(s)
      Kimura G, Kasahara M, Tanaka S, Yasuno S, Fujimoto A, Sato T, Imamoto M, Kosugi S, Ueshima K, Nakao K, on behalf of the ASUCA trial Investigators
    • Organizer
      Kidney Week 2013
    • Place of Presentation
      Atlanta, America
    • Related Report
      2013 Research-status Report
  • [Presentation] Type 2 diabetes and a history of coronary heart disease are additive cardiovascular risks in high-risk hypertensive patients: a subanalysis of the CASE-J Ex2013

    • Author(s)
      Yasuno S, Ueshima K, Tanaka S, Fujimoto A, Kasahara M, Nakao YM, Ogihara T, Saruta T, Nakao K
    • Organizer
      European Society of Cardiology 2013
    • Place of Presentation
      Amsterdam, Netherlands
    • Related Report
      2013 Research-status Report
  • [Presentation] VISCERAL FAT OBESITY MEASURED BY A NEWLY DEVELOPED DUAL BIOELECTRICAL IMPEDANCE ANALYSIS2013

    • Author(s)
      Ishikawa K, Masuda I, Miyawaki T, Fukunaga Y, Hayashi T, Yasuno S, Ueshima K, Kuzuya H
    • Organizer
      American Diabetes Association 73rd Scientific Sessions
    • Place of Presentation
      Chicago, America
    • Related Report
      2013 Research-status Report
  • [Presentation] Impact of blood pressure on new-onset of proteinuria in Japanese population: MIYAKO (Multicenter Investigation for Yearly medical check Assessment in KyotO) surveillance2013

    • Author(s)
      Yasuno S, Ueshima K, Oba K, Tanaka S, Kasahara M, Fujimoto A, Nakao YM, Miyawaki T, Masuda I, Nakao K
    • Organizer
      EuroPRevent 2013
    • Place of Presentation
      Rome, Italy
    • Related Report
      2013 Research-status Report
  • [Book] 特集/循環器内科診療のコントラバーシー『近年のジゴキシンに関する臨床研究:エビデンスの視点から』2016

    • Author(s)
      保野 慎治
    • Total Pages
      4
    • Publisher
      科学評論社
    • Related Report
      2015 Research-status Report
  • [Remarks] プロジェクト内容:健診データを用いた肥満指標と生活習慣病との関係についての検討

    • URL

      http://www.kuhp.kyoto-u.ac.jp/~ebm315/project/miyako.html

    • Related Report
      2015 Research-status Report 2014 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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