Risk factors of progression of proteinuria in shift workers and night workers-a prospective cohort study.

• Project/Area Number: 25460753
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: Osaka University
• Principal Investigator: Moriyama Toshiki 大阪大学, 保健センター, 教授 (30283815)
• Co-Investigator(Kenkyū-buntansha): YAMAMOTO Ryohei 大阪大学, 保健センター, 講師 (00533853) ; SOFUE Tomotaka 大阪大学, 医学系研究科, 教授 (50270674)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 蛋白尿 / 交代勤務 / 夜勤 / AGE / 深夜業務 / ジュース摂取 / 最終糖化産物 / shift work / 睡眠 / シフトワーク

Outline of Final Research Achievements

The aim of the present study is to explore the potential risk factors of progression of proteinuria in night workers and night shift workers using osaka university health care cohort. We also examined the potential relationships between AGE(advanced glycation endproducts) reader value and various medical parametes including proteinuria in cross sectional analysis of osaka university health care cohort. The main findings are 1) Night shift work but not fixed night work is a risk factor of progression of proteinuria in female nurses. 2) Consumption of sugar-containing soft drinks is a potential risk factor for progression of proteinuria. 3) Night shift work is assocated with high AGE reader value.

Research Products

• [Journal Article] Klotho-related molecules upregulated by smoking habit in apparently healthy men: A cross sectional study. (2015)
  • Author(s): K. Nakanishi, M. Nishida, M. Harada, T. Ohama, N. Kawada, M. Murakami, T. Moriyama, K. Yamauchi-Takihara.
  • Journal Title: Scientific Reports Volume: 5 Issue: 1 Pages: 14230-14230
  • DOI: 10.1038/srep14230
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] ジュース摂取頻度は蛋白尿の発症予測因子である (2015)
  • Author(s): 山本陵平
  • Organizer: 第53回全国大学保健管理研究集会
  • Place of Presentation: 盛岡市民文化ホール（岩手県・盛岡市）
  • Year and Date: 2015-09-09