| Project/Area Number |
25460758
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Epidemiology and preventive medicine
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| Research Institution | Kyushu University |
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Principal Investigator |
MASAYO FUKUHARA 九州大学, 医学(系)研究科(研究院), 研究員 (90360057)
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| Co-Investigator(Kenkyū-buntansha) |
KIYOHARA Yutaka 九州大学, 大学院医学研究院環境医学, 教授 (80161602)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 家庭血圧 / 動脈硬化 / 頸動脈エコー / コホート研究 / 内膜中膜複合体厚 / 内膜中膜厚 / 頸動脈狭窄 / 久山町研究 |
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| Outline of Final Research Achievements |
On the basis of combined measurements of clinic blood pressure (CBP) and home BP (HBP), BP status can be divided into normotension (NT), white-coat hypertension (WCHT), masked HT (MHT), and sustained HT (SHT). The objective of this study was to investigate the associations of WCHT, MHT, and SHT with carotid atherosclerosis. This is a cross-sectional survey of 2915 community-dwelling Japanese aged ≧40 years. Mean intima-media thickness (IMT) of carotid arteries was measured using a computer-automated system, and carotid stenosis was defined as diameter stenosis ≧30%.
The geometric average of mean IMT was significantly higher among subjects with WCHT, MHT, and SHT than those with NT. Compared with NT, all types of HT were associated with increased likelihood of carotid stenosis. These associations remained significant even after adjustment for other cardiovascular risk factors. WCHT, as well as MHT, and SHT were associated with carotid atherosclerosis in a general Japanese population.
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