The association between home blood pressure and carotid atherosclerosis

• Project/Area Number: 25460758
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: Kyushu University
• Principal Investigator: MASAYO FUKUHARA 九州大学, 医学(系)研究科(研究院), 研究員 (90360057)
• Co-Investigator(Kenkyū-buntansha): KIYOHARA Yutaka 九州大学, 大学院医学研究院環境医学, 教授 (80161602)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 家庭血圧 / 動脈硬化 / 頸動脈エコー / コホート研究 / 内膜中膜複合体厚 / 内膜中膜厚 / 頸動脈狭窄 / 久山町研究

Outline of Final Research Achievements

On the basis of combined measurements of clinic blood pressure (CBP) and home BP (HBP), BP status can be divided into normotension (NT), white-coat hypertension (WCHT), masked HT (MHT), and sustained HT (SHT). The objective of this study was to investigate the associations of WCHT, MHT, and SHT with carotid atherosclerosis. This is a cross-sectional survey of 2915 community-dwelling Japanese aged ≧40 years. Mean intima-media thickness (IMT) of carotid arteries was measured using a computer-automated system, and carotid stenosis was defined as diameter stenosis ≧30%.
The geometric average of mean IMT was significantly higher among subjects with WCHT, MHT, and SHT than those with NT. Compared with NT, all types of HT were associated with increased likelihood of carotid stenosis. These associations remained significant even after adjustment for other cardiovascular risk factors. WCHT, as well as MHT, and SHT were associated with carotid atherosclerosis in a general Japanese population.

Research Products

• [Journal Article] Hematocrit and the risk of cardiovascular disease in a Japanese community: the Hisayama Study (2015)
  • Author(s): Gotoh S, Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Fukuhara M, Ikeda F, Ago T, Kitazono T, Kiyohara Y
  • Journal Title: Atherosclerosis Volume: 242 Issue: 1 Pages: 199-204
  • DOI: 10.1016/j.atherosclerosis.2015.07.014
  • Peer Reviewed
• [Journal Article] Effect of losartan on serum uric acid in hypertension treated with a diuretic: the COMFORT Study. (2015)
  • Author(s): Matsumura K, Arima H, Tominaga M, Ohtsubo T, Sasaguri T, Fujii K, Fukuhara M, Uezono K, Morinaga Y, Ohta Y, Otonari T, Kawasaki J, Kato I, Tsuchihashi T; COMFORT Investigators.
  • Journal Title: Clin Exp Hypertens Volume: 37 Issue: 3 Pages: 192-196
  • DOI: 10.3109/10641963.2014.933968
  • Peer Reviewed
• [Journal Article] Association of hemoglobin A1c and glycated albumin with carotid atherosclerosis in community-dwelling Japanese subjects: the Hisayama Study (2015)
  • Author(s): Mukai N, Ninomiya T, Hata J, Hirakawa Y, Ikeda F, Fukuhara M, Hotta T, Koga M, Nakamura U, Kang D, Kitazono T, Kiyohara Y
  • Journal Title: Cardiovasc Diabetol Volume: 14 Issue: 1 Pages: 84-84
  • DOI: 10.1186/s12933-015-0247-7
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Trends in the Incidence and Survival of Intracerebral Hemorrhage by its Location in a Japanese Community (2014)
  • Author(s): Gotoh S, Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Fukuhara M, Ikeda F, Shikata K, Kamouchi M, Kitazono T, Kiyohara Y
  • Journal Title: Circulation Journal Volume: 78 Issue: 2 Pages: 403-409
  • DOI: 10.1253/circj.CJ-13-0811
  • NAID: 130003382214
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Non-high-density lipoprotein cholesterol and the development of coronary heart disease and stroke subtypes in a general Japanese population: the Hisayama Study. (2014)
  • Author(s): Imamura T, Doi Y, Ninomiya T, Hata J, Nagata M, Ikeda F, Mukai N, Hirakawa Y, Yoshida D, Fukuhara M, Kitazono T, Kiyohara Y
  • Journal Title: Atherosclerosis Volume: 233 Issue: 2 Pages: 343-348
  • DOI: 10.1016/j.atherosclerosis.2014.01.005
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Serum 1,25-Dihydroxyvitamin D and the Development of Kidney Dysfunction in a Japanese Community (2014)
  • Author(s): Izumaru K, Ninomiya T, Nagata M, Usui T, Yoshida D, Yonemoto K, Fukuhara M, Tsuruya K, Kitazono T, Kiyohara Y
  • Journal Title: Circulation Journal Volume: 78 Issue: 3 Pages: 732-737
  • DOI: 10.1253/circj.CJ-13-0422
  • NAID: 130003382240
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Thresholds of various glycemic measures for diagnosing diabetes based on prevalence of retinopathy in community-dwelling Japanese subjects: the Hisayama Study. (2014)
  • Author(s): Mukai N, Yasuda M, Ninomiya T, Hata J, Hirakawa Y, Ikeda F, Fukuhara M, Hotta T, Koga M, Nakamura U, Kang D, Kitazono T, Kiyohara Y.
  • Journal Title: Cardiovasc Diabetol Volume: 13 Issue: 1 Pages: 45-45
  • DOI: 10.1186/1475-2840-13-45
  • Peer Reviewed / Open Access
• [Journal Article] Trends in the prevalence of type 2 diabetes and prediabetes in community-dwelling Japanese subjects: the Hisayama Study. (2014)
  • Author(s): Mukai N, Doi Y, Ninomiya T, Hirakawa Y, Nagata M, Yoshida D, Hata J, Fukuhara M, Nakamura U, Kitazono T, Kiyohara Y.
  • Journal Title: J Diabetes Invest Volume: 5 Issue: 2 Pages: 162-169
  • DOI: 10.1111/jdi.12136
  • Peer Reviewed / Open Access
• [Journal Article] A low ankle brachial index is associated with an increased risk of cardiovascular disease: the Hisayama Study. (2014)
  • Author(s): Kojima I, Ninomiya T, Hata J, Fukuhara M, Hirakawa Y, Mukai N, Yoshida D, Kitazono T, Kiyohara Y
  • Journal Title: J Atheroscler Thromb Volume: 21 Pages: 966-973
  • NAID: 130004690937
  • Peer Reviewed
• [Journal Article] Significance of plasma adiponectin for diagnosis, neurological severity and functional outcome in ischemic stroke - Research for Biomarkers in Ischemic Stroke (REBIOS) (2014)
  • Author(s): Kuwashiro T, Ago T, Kamouchi M, Matsuo R, Hata J, Kuroda J, Fukuda K, Sugimori H, Fukuhara M, Awano H, Isomura T, Suzuki K, Yasaka M, Okada Y, Kiyohara Y, Kitazono T.
  • Journal Title: Metabolism Volume: 63 Issue: 9 Pages: 1093-1103
  • DOI: 10.1016/j.metabol.2014.04.012
  • Peer Reviewed
• [Journal Article] Brachial-ankle pulse wave velocity predicts the development of cardiovascular disease in a general Japanese population: the Hisayama Study. (2013)
  • Author(s): Ninomiya T, Kojima I, Doi Y, Fukuhara M, Hirakawa Y, Hata J, Kitazono T, Kiyohara Y
  • Journal Title: J Hypertension Volume: 31 Issue: 3 Pages: 477-483
  • DOI: 10.1097/hjh.0b013e32835c5c23
  • Peer Reviewed
• [Journal Article] Clinical significance of plasma VEGF value in ischemic stroke - research for biomarkers in ischemic stroke (REBIOS) study. (2013)
  • Author(s): Matsuo R, Ago T, Kamouchi M, Kuroda J, Kuwashiro T, Hata J, Sugimori H, Fukuda K, Gotoh S, Makihara N, Fukuhara M, Awano H, Isomura T, Suzuki K, Yasaka M, Okada Y, Kiyohara Y, Kitazono T
  • Journal Title: BMC Neurol Volume: 13 Issue: 1 Pages: 32-32
  • DOI: 10.1186/1471-2377-13-32
  • Peer Reviewed
• [Journal Article] White-coat and masked hypertension are associated with carotid atherosclerosis in a general population: the Hisayama Study. (2013)
  • Author(s): Fukuhara M, Arima H, Ninomiya T, Hata J, Hirakawa Y, Doi Y, Yonemoto K, Mukai N, Nagata M, Ikeda F, Matsumura K, Kitazono T, Kiyohara Y.
  • Journal Title: Stroke Volume: 44 Issue: 6 Pages: 1512-1517
  • DOI: 10.1161/strokeaha.111.000704
  • Peer Reviewed
• [Journal Article] Angiopoietin-Like Protein 2 Is Associated With Chronic Kidney Disease in a General Japanese Population: the Hisayama Study. (2013)
  • Author(s): Usui T, Ninomiya T, Nagata M, Takahashi O, Doi Y, Hata J, Fukuhara M, Kitazono T, Oike Y, Kiyohara Y
  • Journal Title: Circ J Volume: 77 Pages: 2311-2317
  • Peer Reviewed
• [Journal Article] Secular trends in cardiovascular disease and its risk factors in Japanese: half-century data from the Hisayama Study (1961-2009). (2013)
  • Author(s): Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Gotoh S, Fukuhara M, Ikeda F, Shikata K, Yoshida D, Yonemoto K, Kamouchi M, Kitazono T, Kiyohara Y.
  • Journal Title: Circulation Volume: 128 Issue: 11 Pages: 1198-1205
  • DOI: 10.1161/circulationaha.113.002424
  • Peer Reviewed
• [Journal Article] Association between ratio of serum eicosapentaenoic acid to arachidonic acid and risk of cardiovascular disease: the Hisayama Study. (2013)
  • Author(s): Ninomiya T, Nagata M, Hata J, Hirakawa Y, Ozawa M, Yoshida D, Ohara T, Kishimoto H, Mukai N, Fukuhara M, Kitazono T, Kiyohara Y.
  • Journal Title: Atherosclerosis Volume: 231 Issue: 2 Pages: 261-267
  • DOI: 10.1016/j.atherosclerosis.2013.09.023
  • Peer Reviewed
• [Journal Article] Elevated depressive symptoms in metabolic syndrome in a general population of Japanese men: a cross-sectional study. (2013)
  • Author(s): Sekita A, Arima H, Ninomiya T, Ohara T, Doi Y, Hirakawa Y, Fukuhara M, Hata J, Yonemoto K, Ga Y, Kitazono T, Kanba S, Kiyohara Y.
  • Journal Title: BMC Public Health Volume: 13 Issue: 1 Pages: 862-862
  • DOI: 10.1186/1471-2458-13-862
  • Peer Reviewed
• [Presentation] 家庭血圧の日間変動と認知症発症との関連：久山町研究． (2015)
  • Author(s): 大石絵美、小原知之、福原正代、坂田智子、秦 淳、大坪俊夫、松村 潔、北園孝成、清原 裕、二宮利治．
  • Organizer: 第38回日本高血圧学会総会
  • Place of Presentation: 松山市
  • Year and Date: 2015-10-10
• [Presentation] 一般住民における臥位高血圧と心血管病発症の関連：久山町研究． (2015)
  • Author(s): 坂田智子、福原正代、大坪俊夫、松村 潔、北園孝成、清原 裕、二宮利治．
  • Organizer: 第38回日本高血圧学会総会
  • Place of Presentation: 松山市
  • Year and Date: 2015-10-10
• [Presentation] Supine hypertension and the development of cardiovascular disease in a general Japanese population: the Hisayama Study. (2015)
  • Author(s): Sakata S, Fukuhara M, Oishi E, Otsubo T, Matsumura K, Kitazono T, Kiyohara Y, Ninomiya T.
  • Organizer: 第38回日本高血圧学会総会
  • Place of Presentation: 松山市
  • Year and Date: 2015-10-10
• [Presentation] 地域高齢者における乳・乳製品摂取が生活機能障害と日常生活動作障害の発生に及ぼす影響：久山町研究． (2015)
  • Author(s): 吉田大悟、二宮利治、小原知之、岸本裕歩、秦 淳、福原正代、永田雅治、北園孝成、清原 裕．
  • Organizer: 第29回日本老年学会総会、第57回日本老年医学会学術集会
  • Place of Presentation: 横浜市
  • Year and Date: 2015-06-14
• [Presentation] Angiopoietin-like Protein 2(ANGPTL2) and the risk of cardiovascular disease in a general Japanese population: the Hisayama Study. (2015)
  • Author(s): Hata J, Ninomiya T, Fukuhara M, Nagata M, Kitazono T, Oike Y, Kiyohara Y.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪市
  • Year and Date: 2015-04-26
• [Presentation] 一般住民における家庭血圧の日間変動性と頸動脈病変との関連：久山町研究 (2014)
  • Author(s): 福原正代、有馬久富、二宮利治、秦 淳、平川洋一郎、米本孝二、松村 潔、北園孝成、清原 裕.
  • Organizer: 第37回日本高血圧学会総会
  • Place of Presentation: 横浜市
  • Year and Date: 2014-10-17 – 2014-10-19
• [Presentation] 地域住民におけるヘマトクリットレベルが心血管病発症に及ぼす影響：久山町研究． (2014)
  • Author(s): 後藤聖司、秦 淳、二宮利治、福原正代、永田雅治、向井直子、池田文恵、小原知之、吉田大悟、岸本裕歩、吾郷哲朗、北園孝成、清原 裕
  • Organizer: 第50回日本循環器病予防学会学術集会
  • Place of Presentation: 京都市
  • Year and Date: 2014-07-20 – 2014-07-21
• [Presentation] 地域住民におけるヘモグロビンA1cレベルと心血管病発症の関係：久山町研究． (2014)
  • Author(s): 池田文恵、秦 淳、二宮利治、福原正代、向井直子、永田雅治、小原知之、吉田大悟、岸本裕歩、北園孝成、清原 裕
  • Organizer: 第50回日本循環器病予防学会学術集会
  • Place of Presentation: 京都市
  • Year and Date: 2014-07-20 – 2014-07-21
• [Presentation] 部位別にみた脳出血発症率の時代的推移：久山町研究． (2014)
  • Author(s): 後藤聖司、秦 淳、永田雅治、福原正代、吾郷哲朗、北園孝成、清原 裕
  • Organizer: 第56回日本老年医学会学術集会・総会
  • Place of Presentation: 福岡市
  • Year and Date: 2014-06-12 – 2014-06-14
• [Presentation] 地域住民における中年期および老年期の喫煙と認知症発症との関連：久山町研究． (2014)
  • Author(s): 小原知之、秦 淳、吉田大悟、福原正代、永田雅治、岸本裕歩、北園孝成、神庭重信、清原 裕
  • Organizer: 第56回日本老年医学会学術集会・総会
  • Place of Presentation: 福岡市
  • Year and Date: 2014-06-12 – 2014-06-14
• [Presentation] 高血圧外来における降圧目標達成の要因の検討と80歳以上高齢者の降圧治療の現状． (2014)
  • Author(s): 茨木 愛、松村 潔、寒水康雄、大坪俊夫、芳賀祥江、村上 曻、関 拓紀、福原正代、北園孝成
  • Organizer: 第3回臨床高血圧フォーラム in HIROSIMA
  • Place of Presentation: 広島市
  • Year and Date: 2014-05-24 – 2014-05-25
• [Presentation] 地域住民における血糖関連指標と頸動脈壁肥厚との関連：久山町研究． (2014)
  • Author(s): 向井直子、平川洋一郎、二宮利治、池田文恵、秦 淳、福原正代、堀田多恵子、古賀正史、中村宇大、康 東天、北園孝成、清原 裕
  • Organizer: 第57回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪市
  • Year and Date: 2014-05-22 – 2014-05-24
• [Presentation] Trends in stroke, coronary heart disease, and cardiovascular risk factors during the past half century in a Japanese community: the Hisayama Study, 1961-2009. (2013)
  • Author(s): Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Gotoh S, Fukuhara M, Ikeda F, Shikata K, Yoshida D, Kamouchi M, Kitazono T, Kiyohara Y
  • Organizer: 22th Eeropean Stroke Conference
  • Place of Presentation: London, United Kingdom
• [Presentation] 糖尿病診断における血糖関連指標のカットオフ値とその有用性の検討：久山町研究． (2013)
  • Author(s): 向井直子、安田美穂、平川洋一郎、二宮利治、池田文恵、秦 淳、福原正代、堀田多恵子、古賀正史、中村宇大、康 東天、北園孝成、清原 裕
  • Organizer: 第56回日本糖尿病学会年次学術集会
  • Place of Presentation: 熊本市
• [Presentation] 蛋白質エネルギー比率と脳卒中発症との関連：久山町研究． (2013)
  • Author(s): 小澤未央、二宮利治、秦 淳、小原知之、平川洋一郎、福原正代、内田和宏、城田知子、北園孝成、清原 裕
  • Organizer: 第49回日本循環器病予防学会・日本循環器管理研究協議会総会
  • Place of Presentation: 金沢市
• [Presentation] 一般住民における随時血圧、家庭血圧および中心血圧と頸動脈病変との関連：久山町研究． (2013)
  • Author(s): 福原正代、有馬久富、二宮利治、秦 淳、平川洋一郎、米本孝二、松村 潔、北園孝成、清原 裕
  • Organizer: 第36回日本高血圧学会総会
  • Place of Presentation: 大阪市
• [Presentation] ロサルタン以外のアンジオテンシン受容体拮抗薬とサイアザイド系利尿薬の併用からロサルタン／ヒドロクロロチアジド合剤への変更が血圧および血液検査値に与える影響：COMFORT試験． (2013)
  • Author(s): 有馬久富、松村 潔、冨永光裕、大坪俊夫、笹栗俊之、藤井弘二、福原正代、上園慶子、守永友希、大田祐子、乙成孝俊、川崎純也、土橋卓也、COMFORT 試験グループ
  • Organizer: 第36回日本高血圧学会総会
  • Place of Presentation: 大阪市
• [Presentation] 一般住民における起床時および就床前家庭血圧と内膜中膜複合体厚との関連：久山町研究． (2013)
  • Author(s): 坂田智子、二宮利治、福原正代、秦 淳、松村 潔、北園孝成、清原 裕
  • Organizer: 第36回日本高血圧学会総会
  • Place of Presentation: 大阪市
• [Book] 日本人の高血圧の治療実態について教えてください．高血圧診療Q&A155エキスパートからの回答． (2014)
  • Author(s): 坂田智子、福原正代、清原 裕
  • Publisher: (株）中外医学社
• [Book] 高血圧症に緯度や人種差で頻度の違いはありますか（黒人, ヒスパニック, アジアなど）？．高血圧診療Q&A155エキスパートからの回答． (2014)
  • Author(s): 福原正代、清原 裕
  • Publisher: (株）中外医学社
• [Remarks] 九州大学大学院医学研究環境医学ホームページ
  • URL: http://www.envmed.med.kyushu-u.ac.jp
• [Remarks] 九州大学大学院医学研究院環境医学ホームページ
  • URL: http://www.envmed.med.kyushu-u.ac.jp/
• [Remarks] 九州大学大学院医学研究院環境医学ホームページ
  • URL: http://www.envmed.med.kyushu-u.ac.jp