Interaction effects of smoking and host factors on breast cancer risk: the evaluation by menopausal status

• Project/Area Number: 25460765
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: Kagoshima University
• Principal Investigator: KORIYAMA Chihaya 鹿児島大学, 医歯学域医学系, 准教授 (30274814)
• Co-Investigator(Kenkyū-buntansha): 秋葉 澄伯 鹿児島大学, 医歯学域医学系, 教授 (50145554) ; 喜島 祐子 鹿児島大学, 医歯学域附属病院, 講師 (60381175)
• Research Collaborator: KANEKO Tomoyo ; Le Tran Ngoan
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 乳がん / 喫煙 / 閉経 / 症例・対照研究 / ホルモン受容体 / HER2 / 疫学

Outline of Final Research Achievements

The purpose of this study is to assess the female breast cancer (BC) risk of both active and passive smoking in a case-control study. In addition to that, interactions between smoking and menopausal status / hormone receptor and HER2 expression status were examined. The study subjects were 223 BC patients and 349 Japanese women. We conducted an interview survey to obtain the information of lifestyle including active and passive smoking.
Regardless of menopausal status, there was a significant association between active smoking and BC risk. The BC risk significantly increased with the number of cigarette and the duration of smoking for pre- and post-menopausal women, respectively. Passive smoking also increased BC risk regardless of menopausal status. There was no significant interaction between smoking and hormone receptor / HER2 expression status.

Research Products

• [Int'l Joint Research] Hanoi Medical University(ベトナム)
• [Int'l Joint Research] Hanoi Medical University(ベトナム)
• [Journal Article] Immediate breast volume replacement using a free dermal fat graft after breast cancer surgery: multi-institutional joint research of short-term outcomes in 262 Japanese patients (2015)
  • Author(s): Kijima Y, Koriyama C, Fujii T et al.
  • Journal Title: Gland Surgery Volume: 4 Pages: 179-194
  • Peer Reviewed / Open Access
• [Presentation] Breast cancer risk of active and passive smoking in post-menopausal women by hormone receptor and HER2 status (2017)
  • Author(s): Tran Thanh Long, Chihaya Koriyama, Hang Thi Minh Lai, Futoshi Uwatoko, Suminori Akiba
  • Organizer: 第24回日本がん予防学会総会
  • Place of Presentation: 大阪国際がんセンター (大阪府・大阪市）
  • Year and Date: 2017-06-16
• [Presentation] Breast cancer risk of active and passive smoking in post-menopausal women by hormone receptor and HER2 status (2016)
  • Author(s): 郡山千早、秋葉澄伯
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（神奈川県・横浜市）
  • Year and Date: 2016-10-06
• [Presentation] BREAST CANCER RISK OF ACTIVE AND PASSIVE SMOKING BY MENOPAUSAL STATUS (2014)
  • Author(s): Chihaya Koriyama
  • Organizer: Asian Pacific Organization for Cancer Prevention Regional Conference
  • Place of Presentation: Hanoi Medical University, Hanoi, Vietnam
  • Year and Date: 2014-11-02 – 2014-11-03
• [Presentation] Association of high-sensitive CRP and risk factors of breast cancer (2014)
  • Author(s): 郡山千早
  • Organizer: 日本癌学会
  • Place of Presentation: 横浜（パシフィコ横浜）
  • Year and Date: 2014-09-25 – 2014-09-27