The analysis of distribution and the construction of basic data base for HTLV-1 carrier in Okinawa Prefecture

• Project/Area Number: 25460767
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: University of the Ryukyus
• Principal Investigator: FUKUSHIMA Takuya 琉球大学, 医学部, 教授 (40336160)
• Co-Investigator(Kenkyū-buntansha): MIYARA Megumi 琉球大学, 医学部保健学科, 助教 (50457686) ; NOMURA Shogo 国立研究開発法人国立がん研究センター, その他の部局, 研究員 (60638477)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 沖縄県 / HTLV-1キャリア / 高分布地域 / 抗糞線虫抗体 / HTLV-1サブタイプ / HTLV-1 / キャリアコホート / 成人細胞白血病・リンパ腫 / 島嶼 / 寄生虫 / 成人T細胞白血病・リンパ腫 / 高齢発症 / 治療難反応性 / 糞線虫感染症 / 沖縄県島嶼部 / HTLV-1キャリア外来 / 好発地域

Outline of Final Research Achievements

In Okinawa, the subtropical region of Japan, is one of the most endemic areas for the Human T-cell Lymphotrophic Virus type-I (HTLV-1) infection. However, the current status of HTLV-1 carriers in Okinawa, particularly in remote islands was not clarified. To clarify relationship of HTLV-1 infection and parasitic infection, 1,133 residents in Ishigaki island were screened for anti-HTLV-1 antibody and parasitic antibodies. We revealed that the positive rate of anti-HTLV-1 antibody among residents of both Ishigaki and Miyako islands was approximately 4%. Out of the 39 HTLV-1 carriers, anti-Strongyloides antibody were detected in 16 patients (41%). The prevalence of anti-Strongyloides antibody positivity was significantly higher among HTLV-1 carriers as compared to non-carriers. Furthermore, the distribution pattern of HTLV-1 subtype with 40% of TaxA (South America type) and 60% of TaxB (Japanese type) in Okinawa was apparently different from mainland Japan with 10% of TaxA and 90% of TaxB.

Research Products

• [Journal Article] Characteristic patterns of relapseafter allogeneic hematopoietic SCT for adult T-cell leukemia-lymphoma: acomparative study of recurrent lesions after transplantation and chemotherapy by the Nagasaki Transplant Group. (2015)
  • Author(s): Itonaga H, Sawayama Y, Taguchi J,Honda S, Taniguchi H, Makiyama J,Matsuo E, Sato S, Ando K, ImanishiD, Imaizumi Y, Yoshida S, Hata T,Moriuchi Y, Fukushima T, MiyazakiY.
  • Journal Title: Bone Marrow Transplant Volume: 50 Issue: 4 Pages: 585-591
  • DOI: 10.1038/bmt.2014.308
  • Peer Reviewed
• [Journal Article] Successful treatment of toxoplasmic encephalitis early diagnosed by a polymerase chain reaction after allogeneic hematopoietic stem cell transplantation: two cases reports and review of the literature. (2015)
  • Author(s): Miyagi T, Itonaga H, Aosai F, Taguchi J, Norose K, Mochizuki K, Fujii H, Furumoto A, Ohama M, Karimata K, Yamanoha A, Taniguchi H, Sato S, Taira N, Moriuchi Y, Fukushima T, Masuzaki H, Miyazaki Y.
  • Journal Title: Transplant Infect Dis. Volume: 17 Issue: 4 Pages: 593-8
  • DOI: 10.1111/tid.12401
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Human T-cell leukemia virus type-I Tax induces the expression of CD83 on T cells. (2015)
  • Author(s): Tanaka Y, Mizuguchi M, Takahashi Y, Fujii H, Tanaka R, Fukushima T, Tomoyose T, Ansari AA, Nakamura M
  • Journal Title: Retrovirology Volume: 12 Issue: 1 Pages: 56-56
  • DOI: 10.1186/s12977-015-0185-1
  • NAID: 120006847303
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Fatal pneumonia and viremia due to human parainfluenza virus type 1 in a patient with adult T-cell leukemia-lymphoma treated with mogamulizumab. (2015)
  • Author(s): Tamaki K, Kinjo T, Aoyama H, Tomoyose T, Nakachi S, Hanashiro T, Shimabukuro N, Tedokon I, Morichika K, Nishi Y, Taira N, Fujita J, Yoshimi N, Fukushima T, Masuzaki H.
  • Journal Title: J Infect Chemother. Volume: 21 Issue: 11 Pages: 20-23
  • DOI: 10.1016/j.jiac.2015.07.001
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Giant Septic Lymphadenitis with Marked Gas Formation Caused by <i>Bacteroides fragilis</i> in a Patient with Adult T-cell Leukemia/lymphoma (2015)
  • Author(s): Tomoyose T, Nakachi S, Nishi Y, Morichika K, Tedokon I, Tamaki K, Shimabukuro N, Hanashiro T, Samura H, Fukushima T, Masuzaki H
  • Journal Title: Internal Medicine Volume: 54 Issue: 22 Pages: 2919-2922
  • DOI: 10.2169/internalmedicine.54.4324
  • NAID: 130005108830
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The intractable intra-abdominal heorrhage with unknown etiology ina patient with severe hemophilia A. (2015)
  • Author(s): Morichika K, Tomoyose T, Nishi Y, Nakachi S, Fukushima T, Masuzaki H.
  • Journal Title: Am J Emarg Volume: 33 Issue: 1 Pages: 129.e1-129.e3
  • DOI: 10.1016/j.ajem.2014.06.038
  • Peer Reviewed
• [Journal Article] A rare case of septic pulmonary embolism caused by infection-associated catheter removal in a patient with Hodgkin's lymphoma. (2014)
  • Author(s): Morichika K, Nakachi S, Tomoyose T, Shimabukuro N, Tamaki K, Tedokon I, Nishi Y, Hyakuna N, Fukushima T, Masuzaki H.
  • Journal Title: Int Med Volume: 53 Pages: 1215-1220
  • NAID: 130004466342
  • Peer Reviewed
• [Journal Article] Japan Clinical Oncology Group (JCOG) prognostic index and characterization of long-term survivors of aggressive adult T-cell leukaemia-lymphoma (JCOG0902A). (2014)
  • Author(s): Fukushima T, Nomura S, Shimoyama M, Shibata T, Imaizumi Y, Moriuchi Y, Tomoyose T, Uozumi K, Kobayashi Y, Fukushima N, Utsunomiya A, Tara M, Nosaka K, Hidaka M, Uike N, Yoshida S, Tamura K, Ishitsuka K, Kurosawa M, Nakata M, Fukuda H, Hotta T, Tobinai K, Tsukasaki K.
  • Journal Title: Br J Haematol Volume: 166 Issue: 5 Pages: 739-748
  • DOI: 10.1111/bjh.12962
  • Peer Reviewed
• [Journal Article] Expression of myeloperoxidase in acute myeloid leukemia blasts mirrors the distinct DNA methylation pattern involving the downregulation of DNA methltransferase DNMT3B. (2014)
  • Author(s): Itonaga H, Imanishi D, Wong YF, Sato S, Ando K, Sawayama Y, Sasaki D, Tsuruda K, Hasegawa H, Imaizumi Y, Taguchi J, Tsushima H, Yoshida S, Fukushima T, Hata T, Moriuchi Y, Yanagihara K, Miyazaki Y.
  • Journal Title: Leukemia Volume: in press Issue: 7 Pages: 1459-1466
  • DOI: 10.1038/leu.2014.15
  • Peer Reviewed
• [Journal Article] 橋本病と成人T細胞白血病リンパ腫（くすぶり型）を合併したループスアンチコアグラント低プロトロンビン血症症候群の1例. (2014)
  • Author(s): 島袋奈津紀、西由希子、仲地佐和子、玉城啓太、手登根伊織、森近一穂、友寄毅昭、福島卓也、益崎裕章.
  • Journal Title: 日本内科学会雑誌 Volume: 103 Pages: 1935-1938
  • NAID: 130005091968
  • Peer Reviewed
• [Journal Article] 成人T細胞白血病・リンパ腫の治療 (2014)
  • Author(s): 福島卓也
  • Journal Title: 臨床血液 Volume: 55 Pages: 1952-1961
  • NAID: 130004696088
• [Journal Article] Molecular analysis of the BCR-ABL1 kinase domain in chronic-phase chronic myelogenous leukemia treated with tyrosine kinase inhibitors in practice: study by the Nagasaki CML Study Group. (2013)
  • Author(s): Itonaga H, Fukushima T, Miyazaki Y, et al.
  • Journal Title: Leuk Res Volume: 38 Issue: 1 Pages: 76-83
  • DOI: 10.1016/j.leukres.2013.10.022
  • NAID: 120006986778
  • Peer Reviewed
• [Journal Article] Feasibility of cord blood transplantation in chemosensitive adult T-cell leukemia/lymphoma: a retrospective analysis of the Nagasaki Transplantation Network (2013)
  • Author(s): Fukushima T, Itonaga H, Moriuchi Y, Yoshida S, Taguchi J, Imaizumi Y, Imanishi D, Tsushima H, Sawayama Y, Matsuo E, Hata T, Miyazaki Y
  • Journal Title: Int J Hematol Volume: 97 Issue: 4 Pages: 485-490
  • DOI: 10.1007/s12185-013-1307-y
  • NAID: 10031168515
  • Peer Reviewed
• [Journal Article] Distinct clinical features of infectious complications in adult T-cell leukemia/lymphoma patients after allogeneic hematopoietic stem cell transplantation: a retrospective analysis in the Nagasaki transplant group (2013)
  • Author(s): Itonaga H, Taguchi J, Fukushima T, Tsushima H, Sato S, Ando K, Sawayama Y, Matsuo E, Yamasaki R, Onimaru Y, Imanishi D, Imaizumi Y, Yoshida S, Hata T, Moriuchi Y, Honda S, Miyasaki Y
  • Journal Title: Biol Blood Marrow Transplant Volume: 19 Issue: 4 Pages: 607-615
  • DOI: 10.1016/j.bbmt.2013.01.011
  • NAID: 120006985927
  • Peer Reviewed
• [Journal Article] Treatment of relapsed adult T-cell leukemia/lymphoma after allogeneic hematopoietic stem cell transplantation: the Nagasaki Transplant Group experience (2013)
  • Author(s): Itonaga H, Tsushima H, Taguchi J, Fukukshima T, Taniguchi H, Sato S, Ando K, Sawayama Y, Matsuo E, Yamasaki R, Onimaru Y, Imanishi D, Imaizumi YYoshida S, Hata T, Moriuchi Y, Uike N, Miyazaki Y
  • Journal Title: Blood Volume: 121 Issue: 1 Pages: 219-225
  • DOI: 10.1182/blood-2012-07-444372
  • Peer Reviewed
• [Presentation] Association of HTLV-1 Infection and Positivity of Anti-Strongyloides Antibody in Ishigaki Island (2016)
  • Author(s): Carmina Louise Hugo Guerrero, Yukako Kaneshiro, Shugo Sakihama, Megumi Kuba-Miyara, Takaki Hashimoto, Takuya Fukushima
  • Organizer: 第61回日本臨床検査医学会九州地方会・第27回日本臨床化学会九州支部総会
  • Place of Presentation: 長崎大学医学部（長崎県長崎市）
  • Year and Date: 2016-03-19
• [Presentation] 沖縄県におけるhuman T-lymphotropic virus type I（HTLV-1）のtaxサブタイプ解析 (2015)
  • Author(s): 崎浜 秀悟、齊藤 峰輝、宮良 恵美、平良 直也、宮城 敬、林 正樹、友寄 毅昭、仲地 佐和子、西 由希子、玉城 啓太、森近 一穂、内原 潤之介、田中 勇悦、益崎 裕章、福島 卓也
  • Organizer: 第1回日本検査血液学会九州支部学術集会・第28回博多シンポジウム
  • Place of Presentation: 福岡大学病院（福岡県福岡市）
  • Year and Date: 2015-11-28
• [Presentation] A screening study of asymptomatic human T-lymphotropic virus type-I (HTLV-1) carriers and establishment of a support system for them in Ishigaki Island in Okinawa, Japan (口演) (2015)
  • Author(s): Yukako Kaneshiro Megumi Kuba-Miyara, Syugo Sakihama, Hikari Taira, Eiko Ichikawa, Mitoko Maekouchi, Reiko Uehara, Takaki Hashimoto, Takuya Fukushima
  • Organizer: The 47th Asia Pacific Academic Consortium for Public Health Conference
  • Place of Presentation: Bandung Indonesia
  • Year and Date: 2015-10-21
  • Int'l Joint Research
• [Presentation] The distribution of human T-lymphotropic virus type I (HTLV-1) tax genotype in Okinawa is different from mainland, Japan, (2015)
  • Author(s): Shugo Sakihama, Megumi Kuba-Miyara, Mineki Saito, Takeaki Tomoyose, Naoya Taira, Takashi Miyagi, Masaki Hayashi, Sawako Nakachi, Yukiko Nishi, Keita Tamaki, Kazuho Morichika, Junnosuke Uchihara, Yuetsu Tanaka, Hiroaki Masuzaki, Takuya Fukushima
  • Organizer: The 47th Asia Pacific Academic Consortium for Public Health Conference
  • Place of Presentation: Bandung Indonesia
  • Year and Date: 2015-10-21
  • Int'l Joint Research
• [Presentation] ガイドライン基づくATL治療戦略 (2015)
  • Author(s): 福島卓也
  • Organizer: 第77回日本血液学会学術集会
  • Place of Presentation: ホテル日航金沢（石川県金沢市）
  • Year and Date: 2015-10-16
  • Invited
• [Presentation] 沖縄県におけるHTLV-1のtax遺伝子サブタイプ解析 (2015)
  • Author(s): 崎浜 秀悟、宮良 恵美、齊藤 峰輝、平良 直也、宮城 敬、林 正樹、友寄 毅昭、仲地 佐和子、西 由希子、玉城 啓太、森近 一穂、内原 潤之介、田中 勇悦、益崎 裕章、福島 卓也
  • Organizer: 第2回日本HTLV-1学会学術集会
  • Place of Presentation: 東京大学医科学研究所（東京都港区）
  • Year and Date: 2015-08-21
• [Presentation] Current issues and new trends in allogeneic SCT for ATL (2015)
  • Author(s): Takuya Fukushima
  • Organizer: The Seventh T-cell Lymphoma Forum
  • Place of Presentation: サンフランシスコ
  • Year and Date: 2015-01-29 – 2015-01-31
  • Invited
• [Presentation] 成人T細胞白血病・リンパ腫に対する同種造血幹細胞移植後、キメラ状態が持続している症例. (2014)
  • Author(s): 崎浜秀悟、宮良恵美、宮城敬、平良直也、田中勇悦、福島卓也.
  • Organizer: 第49回日臨技九州支部医学検査学会
  • Place of Presentation: 沖縄
  • Year and Date: 2014-11-01 – 2014-11-02
• [Presentation] Clinical features of adult T-cell leukemia/lymphoma (ATL) in Okinawa Prefecture. (2014)
  • Author(s): Yukiko Nishi, Takuya Fukushima, Shogo Nomura, Takeaki Tomoyose, Sawako Nakachi, Noya Taira, Takashi Miyagi, Kaori Karimata, Masayo Yohama, Atsushi Yamanoha, Kazumitsu Tamaki, Masaki Hayashi, Hitoshi Arakaki, Junnosuke Uchihara, Kazuiku Ooshiro, Yoshitaka Asakura, Yuetsu Tanaka, Hiroaki Masuzaki.
  • Organizer: 第76回日本血液学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2014-10-31 – 2014-11-02
• [Presentation] 成人細胞白血病・リンパ腫の治療 (2014)
  • Author(s): 福島卓也
  • Organizer: 第76回日本血液学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2014-10-31 – 2014-11-02
  • Invited
• [Presentation] 移植免疫を利用したATL移植の最適化：DLIを中心に. シンポジウム成人T細胞白血病／リンパ腫(ATLL)に対する造血幹細胞移植の最適化. (2014)
  • Author(s): 福島卓也
  • Organizer: 第36回日本造血細胞移植学会総会
  • Place of Presentation: 沖縄
  • Invited
• [Presentation] Two cases of fatal opportunistic infections occurred in ATL patients treated with mogamulizumab. (2013)
  • Author(s): 玉城啓太、西由希子、友寄毅昭、仲地佐和子、島袋奈津紀、手登根伊織、森近一穂、福島卓也、青山肇、益崎裕章
  • Organizer: 第75回日本血液学会学術集会
  • Place of Presentation: 札幌
• [Presentation] Possible higher frequency of anti-erythrocyte antibodies in adult patients with hemophilia. (2013)
  • Author(s): 友寄毅昭、仲地佐和子、西由希子、森近一穂、玉城啓太、手登根伊織、島袋奈津紀、山城剛、福島卓也、益崎裕章
  • Organizer: 第75回日本血液学会学術集会
  • Place of Presentation: 札幌
• [Book] 血液内科 (2015)
  • Author(s): 友寄毅昭、益崎裕章、福島卓也
  • Total Pages: 6
  • Publisher: 科学評論社
• [Book] [8.成人Ｔ細胞白血病リンパ腫(ＡＴＬ)] 造血器腫瘍診療ガイドライン2013年度版.(一般社団法人日本血液学会編集 (2013)
  • Author(s): 福島卓也、塚崎邦弘
  • Total Pages: 328
  • Publisher: 金原出版㈱