The effects of the insulin resistance on the longitudinal trends by the mixed effects model of blood pressure and the metabolic factors in Japanese

• Project/Area Number: 25460770
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: Sapporo Medical University
• Principal Investigator: Saitoh Shigeyuki 札幌医科大学, 保健医療学部, 教授 (60253994)
• Co-Investigator(Kenkyū-buntansha): OHONISHI Hirohumi 札幌医科大学, 医学部, 准教授 (20359996)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 健康診査 / mixed effects model / 血圧 / インスリン抵抗性 / 心血管疾患 / 疫学 / 高血圧 / ＣＲＴ法 / ロジスティック回帰分析 / ROC曲線 / 血圧変動性 / 住民健診 / 時系列データ / 経年変化 / 糖尿病 / 経年的変化 / ランダム係数モデル

Outline of Final Research Achievements

In this study, we examined the effect of IR on the longitudinal trends of BP from young adulthood through eighth decade of life in a longitudinal cohort study.In Tanno-Sobetsu study, we had observed longitudinally 6,198 subjects who participated in every medical examination from 1998 to 2005. A total of medical examinations were made over the course of follow-up in 1,578 subjects. The effect of IR by Matsuda-Defuronzo index on longitudinal changes of blood pressure and metabolic CVD risk factor were estimated by modeling rate of change for 1,578 subjects based on 4,826 data points in mixed effects model. IR significantly predicted the natural histories of systolic blood pressure (SBP), diastolic blood pressure (DBP) and triglyceride (TG) adjusted for habitual drink, smoking, and body mass index in both male and female.
The natural histories of BP and TG were higher in subjects with the high IR group than in those of low IR group from young adulthood into the eighty decade of life.

Research Products

• [Journal Article] Combination of type 2 diabetes and smoking increases total cancer mortality in Japanese men using competing risk analysis: the Tanno-Sobetsu study (2015)
  • Author(s): Ohnishi H, Saitoh S, Akasaka H, Furukawa T, Mori M, Miura T.
  • Journal Title: Diabetol Int. Volume: 5 Issue: 2 Pages: 1-8
  • DOI: 10.1007/s13340-015-0232-0
  • NAID: 40020883350
  • Peer Reviewed / Open Access
• [Journal Article] The combination of abdominal obesity and high-sensitivity C-reactive protein predicts new-onset (2015)
  • Author(s): Fujii M, Ohnishi H, Saitoh S, Akasaka H, Miura T, Mori M.
  • Journal Title: Hypertens Res. Volume: 38 Pages: 426-432
  • Peer Reviewed
• [Journal Article] Elevation of circulating fatty acid-binding protein 4 is independently associated with left ventricular diastolic dysfunction in a general population. (2014)
  • Author(s): Fuseya T, Furuhashi1 M, Yuda S, Muranaka A, Kawamukai M, MitaT, Ishimura S, Watanabe Y, HoshinaK, Tanaka M, Ohno K, Akasaka H, OhnishiH, YoshidaH, Saitoh S, Shimamoto K, Miura T.
  • Journal Title: Cardiovascular Diabetology Volume: 13 Pages: 1-9
  • Peer Reviewed / Open Access
• [Journal Article] Circulating levels of fatty acid-binding protein family and metabolic phenotype in the general population (2013)
  • Author(s): Ishimura S, Furuhashi M, Watanabe Y, Hoshina K, Fuseya T, Mita T, Okazaki Y, Koyama M, Tanaka M, Akasaka H, Ohnishi H, Yoshida H, Saitoh S, Miura T.
  • Journal Title: PLoS ONE Volume: 8 Pages: 1-7
  • Peer Reviewed
• [Journal Article] Glucagon-Like Peptide-1 Secretory Function as an Independent Determinant of Blood Pressure: Analysis in the Tanno-Sobetsu Study. (2013)
  • Author(s): Yoshihara M, Akasaka H, Ohnishi H, Miki T, Furukawa T, Saitoh S, Miura T.
  • Journal Title: PLoS ONE Volume: 8 Issue: 7 Pages: 1-8
  • DOI: 10.1371/journal.pone.0067578
• [Journal Article] Associations between serum 25-hydroxyvitamin D concentration and physical performance in old-old people living in a northern area of Japan. (2013)
  • Author(s): Mizumoto A, Ihira H, Yasuda K, Makino K, Miyabe K, Saitoh S, Ohnishi H, Suzuki T, Furuna T
  • Journal Title: Gerontology & Geriatric Research Volume: 2 Pages: 1-6
• [Presentation] 血糖管理と動脈硬化疾患予防のEBM (2014)
  • Author(s): 斎藤重幸
  • Organizer: 第29回日本糖尿病合併症学会
  • Place of Presentation: 都市センターホテル（東京都・千代田区）
  • Year and Date: 2014-10-03 – 2014-10-04
  • Invited
• [Presentation] 糖尿病予防のキーポイント (2014)
  • Author(s): 斎藤重幸，赤坂 憲，大西浩文
  • Organizer: 第50回日本循環器病予防予防学会学術集会
  • Place of Presentation: 都メッセ（京都府・左京区）
  • Year and Date: 2014-07-19 – 2014-07-20
  • Invited
• [Book] メタボ時代の心血管疾患予防と管理：メタボリックシンドロームの疫学・予防対策 (2013)
  • Author(s): 斉藤重幸
  • Total Pages: 192
  • Publisher: 診断と治療社