| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Blood high-density lipoprotein (HDL）cholesterol(HDL-C) is generally thought to be an anti-atherosclerotic marker; however, there is an on-going debate about the effects of high and/or raising HDL-C levels on vascular health. Our study was aimed to study this topic by measuring the oxidized HDL (a marker of HDL quality), thereby leading to a deeper understanding of HDL and a proposal of HDL quality management. Several conditions, such as smoking, metabolic disorder and coronary disease, were associated with high oxidized HDL levels, seemingly requiring attention to atherosclerosis in such cases. Lipid-lowering conditions could regulate the oxidized HDL level, regardless of the HDL-C level. Further studies on the oxidized HDL are warranted for the prevention of atherosclerosis.
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