| Project/Area Number |
25460778
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Epidemiology and preventive medicine
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
OKAMURA Tomonori 慶應義塾大学, 医学部, 教授 (00324567)
HIGASHIYAMA Aya 兵庫医科大学, 医学部, 助教 (20533003)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | コホート研究 / 生活習慣病 / 自己抗体 |
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| Outline of Final Research Achievements |
To examine the relationship between the positive expression of the auto antibodies and the new onset of the life-style related diseases in general population for the protection of cardiovascular diseases, we evaluated the association of rheumatoid factor (RF), anti-nuclear antibody (ANA) and anti-CCP antibody (CCP) and the new onset of hypertension, dyslipidemia and diabetes mellitus in healthy people of Kobe city. During two years follow-up periods, no significant relation between the positive expression of RF, ANA and CCP and the life-style related diseases. Further study with longer follow-up period should be needed to evaluate these relationships and explore the optimal cut-off point of auto antibodies for detection of the life-style related diseases.
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