The epidemiological study about the association between the dietary intake of polyunsaturated fatty acids and the progression of renal impairment in a population of community-dwelling Japanese

• Project/Area Number: 25460783
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: Kurume University
• Principal Investigator: FUKAMI AKO 久留米大学, 医学部, 助教 (90449926)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 多価不飽和脂肪酸 / 微量アルブミン尿 / 住民検診 / 栄養調査 / 疫学研究 / アルブミン尿 / 腎障害

Outline of Final Research Achievements

The dietary intake of ω3 polyunsaturated fatty acids(PUFA) were increased in 10 years compared to those of ω6 PUFA. Serum eicosapentanoic acid to arachidonic acid ratio (EPA/AA ratio) were significantly higher in fishing community than in farming community, because people in fishing community eat fish oil more than those in farming community. Serum EPA or DHA levels were positively correlate to the dietary intake of ω3 PUFA, but there wasn’t significant association between serum AA levels and the dietary intake of ω6 PUFA. Therefore we revealed that it is important to eat muchω3 PUFA to elevate serum EPA/AA ratios. In cross sectional study, we demonstrated that serum EPA/AA ratio was strongly associated with microalbuminuria. But serum EPA/AA ratio at baseline were not predicted of the progression of microalbuminuria in prospective study.

Research Products

• [Journal Article] Association of serum eicosapentaenoic acid to arachidonic acid ratio with microalbuminuria in a population of community-dwelling Japanese. (2015)
  • Author(s): Fukami A, Adachi H, Hirai Y, Enomoto M, Otsuka M, Kumagai E, Nakamura S, Yoshimura A, Obuchi A, Nohara Y, Nakao E, Hori K, Fukumoto Y.
  • Journal Title: Atherosclerosis Volume: 239 Issue: 2 Pages: 577-582
  • DOI: 10.1016/j.atherosclerosis.2015.02.033
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Association of serum eicosapentaenoic acid to arachidonic acid ratio with microalbuminuria in a population of community-dwelling Japanese (2016)
  • Author(s): A Fukami
  • Organizer: 2016 Asian Pacific Congress of Nephrology
  • Place of Presentation: Perth Convention and Exhibition Centre
  • Year and Date: 2016-09-17
• [Presentation] Serum Zinc-α2-glycoprotein Levels were Associated with Carotid Intima Media Thickness in Females in a Population of Community-dwelling Japanese (2015)
  • Author(s): A Fukami
  • Organizer: 25th European Meeting on Hypertension and Cardiovascular Protection
  • Place of Presentation: MICO MILANO CONGRESS
  • Year and Date: 2015-06-12
  • Int'l Joint Research