| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
(1) In a derivation case-control study, six single nucleotide polymorphisms were selected for synthesis of the genetic risk score. A dose-dependent association was observed between colorectal cancer risk and genetic risk score. The c statistic for a risk prediction model which included the genetic risk score and conventional risk factors was 0.7167, versus 0.7009 with the conventional risk factors only (P=0.0013). In a replication population, corresponding c statistics were 0.6356 and 0.6391 with no statistical significance. We could indicate the possibility of the risk prediction model for colorectal cancer in Japanese populations.
(2) We conducted a pilot study to evaluate the impact of a breast cancer risk prediction model on psychosocial, behavioral, educational, and communication outcomes. Adequate information for a risk prediction did not increase cancer worry among study participants and improved their health awareness.
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