| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Long-time working increases cardiovascular diseases even in young workers. However, the mechanisms for this have not yet been elucidated. We analyzed biomarkers to clarify the pathobiochemical mechanisms involved in the development of cardiovascular diseases induced by long-time working in office and factory workers. We measured the followings twice (1-year interval): small dense (SD) low-density lipoprotein (LDL); total cholesterol; LDL cholesterol; high-density lipoprotein cholesterol. We also used questionnaires concerning smoking habit and body weight gain or loss time twice with 1-year interval. In smokers with overtime work, SD-LDL and the ratio of SD-LDL to LDL significantly increased however, LDL did not change significantly. In non-smokers with overtime work, only the ratio of SD-LDL to LDL increased significantly. Lowering SD-LDL might be of importance and beneficial in preventing cardiovascular events in office and factory workers with long-time working.
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