Longitudinal study of cardiovascular multi-biomarkers in long-time workers.

• Project/Area Number: 25460795
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hygiene and public health
• Research Institution: Sugiyama Jogakuen University (2016-2017); Nagoya University (2013-2015)
• Principal Investigator: Hirai Makoto 椙山女学園大学, 看護学部, 教授 (90242875)
• Co-Investigator(Kenkyū-buntansha): 玉腰 浩司 名古屋大学, 医学系研究科(保健), 教授 (30262900)
• Project Period (FY): 2013-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 長時間労働 / バイオマーカー / small-dense LDL / 心血管バイオマーカー / 過重労働 / 心血管系 / 縦断研究 / LDLコレステロール / MDA-LDL / バイオマーカ

Outline of Final Research Achievements

Long-time working increases cardiovascular diseases even in young workers. However, the mechanisms for this have not yet been elucidated. We analyzed biomarkers to clarify the pathobiochemical mechanisms involved in the development of cardiovascular diseases induced by long-time working in office and factory workers. We measured the followings twice (1-year interval): small dense (SD) low-density lipoprotein (LDL); total cholesterol; LDL cholesterol; high-density lipoprotein cholesterol. We also used questionnaires concerning smoking habit and body weight gain or loss time twice with 1-year interval. In smokers with overtime work, SD-LDL and the ratio of SD-LDL to LDL significantly increased however, LDL did not change significantly. In non-smokers with overtime work, only the ratio of SD-LDL to LDL increased significantly. Lowering SD-LDL might be of importance and beneficial in preventing cardiovascular events in office and factory workers with long-time working.

Research Products

• [Journal Article] Life activities improve heart rate variabilitiy in patients with mild hypertension and/or the initial stage of heart failure (2014)
  • Author(s): NAKAYAMA Natsuki, NEGI koji, WATANABE Koji, HIRAI Makoto
  • Journal Title: Journal of Clinical Nursing Volume: 23 Pages: 367-373
  • Peer Reviewed
• [Journal Article] Impaired Autonomic Nerve Activity During Sleep in Family Caregivers of Ambulatory Dementia Patients in Japan (2014)
  • Author(s): SAKURAI Shihomi、OHNISHI Joji、HIRAI Makoto
  • Journal Title: Biological Research for Nursing Volume: 17 Issue: 1 Pages: 111-111
  • DOI: 10.1177/1099800414524050
  • Peer Reviewed
• [Journal Article] Clinical outcome of implantable cardioverter defibrillators with recalled and non-recalled leads in Japanese patients. Increased failure rate of the Sprint Fidelis lead (2014)
  • Author(s): Yanagisawa S, Inden Y, Shimano M, Yoshida N, Ichiyanagi H, Fujita M, Ohguchi S, Ishikawa S, Kato H, Okumura S, Miyoshi A, Nagao T, Yamamoto T, Hirai M, Murohara T
  • Journal Title: Circ J Volume: 78 Pages: 353-359
  • NAID: 130003382213
  • Peer Reviewed
• [Journal Article] Cystatin C as a predictor of mortality and cardiovascular morbidity after cardiac resynchronization therapy (2013)
  • Author(s): Yamamoto T, Shimano M, Inden Y, Miyata S, Inoue Y, Yoshida N, Tsuji Y, Hirai M, Murohara T
  • Journal Title: Circ J Volume: 77 Pages: 2751-2756
  • NAID: 10031196827
  • Peer Reviewed
• [Presentation] Relationship of Mechanical Dyssynchrony to Long-Term Clinical Outcome after Cardiac Resynchronization Therapy with Defibrillator (2014)
  • Author(s): Hiroyuki Kato, Yasuya Inden, Tomoyuki Nagao, Satoshi Okumura, Aya Miyoshi, Satoshi Yanagisawa, Toshihiko Yamamoto, Shiou Ohguchi, Shinji Ishikawa, Masaya Fujita, Naoki Yoshida, Masayuki Shimano, Makoto Hirai, Toyoaki Murohara
  • Organizer: The 78th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: Tokyo
• [Presentation] Clinical Outcomes of Implantable Cardioverter-Defibrillators with Recalled and Non-recalled Leads in Japanese Patients: Increased Failure Rates of Sprint Fidelis Leads (2014)
  • Author(s): Satoshi Yanagisawa, Yasuya Inden, Masayuki Shimano, Hiroshi Ichiyanagi, Masaya Fujita, Shiou Ohguchi, Shinji Ishikawa, Toshihiko Yamamoto, Hiroyuki Kato, Satoshi Okumura, Aya Miyoshi , Tomoyuki Nagao, Makoto Hirai, Toyoaki Murohara
  • Organizer: The 78th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: Tokyo
• [Presentation] The Relationship between Contact Force and Recurrences of Paroxysmal Atrial Fibrillation Ablation (2014)
  • Author(s): Masaya Fujita, Yasuya Inden, Tomoyuki Nagao, Satoshi Okumura, Hiroyuki Kato, Aya Miyoshi, Satoshi Yanagisawa, Toshihiko Yamamoto, Shiou Ohguchi, Shinji Ishikawa, Masayuki Shimano, Makoto Hirai, Toyoaki Murohara
  • Organizer: The 78th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: Tokyo
• [Presentation] Activities improve heart rate variability in patients with mild hypertension and/or stable angina pectoris (2013)
  • Author(s): NAKAYAMA Natsuki, NEGI Koji, WATANABE Koji, HIRAI Makoto
  • Organizer: International Council of Nursing
  • Place of Presentation: Melbourne, Australia
• [Presentation] Relationship Between Sleep Quality And Stress In Japanese Family Caregivers: An Investigation Using Objective And Subjective Date (2013)
  • Author(s): SAKURAI Shihomi、KOHNO Yumiko、SAKURAI Nobuhiko、MAEKAWA Atsuko、HIRAI Makoto
  • Organizer: The 11th International Family Nursing Conference
  • Place of Presentation: Minneapolis, U.S.A.