| Project/Area Number |
25460797
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hygiene and public health
|
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| Research Institution | Fujita Health University (2014-2015)
Nagoya University (2013) |
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Principal Investigator |
NAITO Hisao 藤田保健衛生大学, 医学部, 講師 (90547556)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKAJIMA Tamie 中部大学, 生命健康科学部, 教授 (10020794)
ISHII Akira 名古屋大学, 大学院医学系研究科, 教授 (30252175)
KITAMORI Kazuya 金城学院大学, 生活環境学部, 准教授 (80387597)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | NASH / 肝線維化 / コレステロール / 胆汁酸 / グルクロン酸抱合 / 高血圧 / 生活習慣病 / BSEP / MRP3 / Cyp7a1 |
|---|
| Outline of Final Research Achievements |
High-fat and -cholesterol diet (HFC) induced fibrotic steatohepatitis in stroke-prone spontaneously hypertensive rat (SHRSP) 5/Dmcr, the fifth substrain from SHRSP. This study aimed to clarify bile acid (BA) kinetic differences in HFC-induced fibrosis between SHRSP5/Dmcr and the mother strains. HFC decreased bile salt export pump and increased BA concentrations in the liver, especially chenodeoxycholic acid (CDCA) which is toxicity. Furthermore, decreases of constitutive androstane receptor, pregnane X receptor, and UDP-glucuronosyltransferase activity were more prominent about fibrotic development. The greater progression of fibrosis induced by HFC may be due to greater suppression of UDP-glucuronosyltransferase activity detoxifying toxicants, such as hydrophobic BAs; e.g. CDCA.
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