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Basic research for cancer prevention by combinatorial treatment of food constituents based on the signal transduction pathways associated with carcinogenesis

Research Project

Project/Area Number 25460809
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Hygiene and public health
Research InstitutionJikei University School of Medicine

Principal Investigator

Yogosawa Shingo  東京慈恵会医科大学, 医学部, 講師 (70381936)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords予防医学 / 食品成分 / 癌予防 / 細胞増殖シグナル伝達系 / 癌 / 食品 / 生理活性 / 衛生 / 社会医学 / 成人保健 / 悪性腫瘍
Outline of Final Research Achievements

The promising chemopreventive effects of food factors on malignant tumors have been reported extensively. However, desirable effects of treatment with a single agent mostly requires high doses, and there are many cases that are unachievable by an intake from food. It has been considered that various food-ingredients combined compositely show chemopreventive effects, but the evidence is still not enough. Paying attention to MEK-ERK and PI3K-Akt signal transduction pathways, considered to be one of the most important pathways for cancer development, it was shown that equol derived from soy, enhanced the inhibitory effect of brassinin, derived from brassica vegetables, on growth of human colon cancer cells via cell-cycle arrest and apoptosis. In addition, combination of emetine with cisplatin was shown to be useful for growth inhibition of human ovarian cancer cells.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (18 results)

All 2016 2015 2013 Other

All Journal Article (4 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (8 results) (of which Invited: 1 results) Remarks (6 results)

  • [Journal Article] 交替勤務制(シフトワーク)による発がんリスク上昇2016

    • Author(s)
      与五沢真吾、柳澤裕之
    • Journal Title

      産業医学ジャーナル

      Volume: 29 Pages: 85-88

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Inadequate intake of zinc exacerbates blood pressure and renal function via superoxide radical-induced oxidative stress2015

    • Author(s)
      Yanagisawa H, Kido T, Yogosawa S, Sato O, Sakae K, Suka M.
    • Journal Title

      Biomedical Research on Trace Elements

      Volume: 26 Issue: 3 Pages: 117-123

    • DOI

      10.11299/brte.26.117

    • NAID

      130005113920

    • ISSN
      0916-717X, 1880-1404
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The alkaloid emetine sensitizes ovarian carcinoma cells to cisplatin through downregulation of bcl-xL2015

    • Author(s)
      Sun Q., et al.
    • Journal Title

      Int J Oncol

      Volume: 46 Issue: 1 Pages: 389-394

    • DOI

      10.3892/ijo.2014.2703

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Combination of a novel HDAC inhibitor OBP-801/YM753 and a PI3K inhibitor LY294002 synergistically induces apoptosis in human endometrial carcinoma cells due to increase of Bim with accumulation of ROS2013

    • Author(s)
      Yoshioka T, Yogosawa S, Yamada T, Kitawaki J, Sakai T.
    • Journal Title

      Gynecologic Oncology

      Volume: 129 Issue: 2 Pages: 425-432

    • DOI

      10.1016/j.ygyno.2013.02.008

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 科学的根拠に基づく復職ガイダンス作成の試み2016

    • Author(s)
      小島原典子、遠藤源樹、福本正勝、斉藤利恵、對木博一、品田佳代子、与五沢真吾、山口直人
    • Organizer
      第89回日本産業衛生学会
    • Place of Presentation
      福島市音楽堂
    • Year and Date
      2016-05-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 酸化亜鉛ナノ粒子のチャイニーズハムスター雌肺線維芽細胞へ及ぼす小核の誘発と酸化ストレスの関与について2016

    • Author(s)
      関良子、与五沢真吾、須賀万智、柳澤裕之
    • Organizer
      第86回日本衛生学会学術総会
    • Place of Presentation
      旭川市民文化会館
    • Year and Date
      2016-05-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] 食品成分によるがん予防の可能性2015

    • Author(s)
      与五沢真吾
    • Organizer
      第38回日本産業衛生学会関東産業衛生技術部会研修会
    • Place of Presentation
      十文字学園女子大学
    • Year and Date
      2015-10-31
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 亜鉛欠乏と亜鉛過剰摂取における精巣マクロファージ炎症反応の検討2015

    • Author(s)
      木戸尊將、内匠正太、関良子、与五沢真吾、須賀万智、柳澤裕之
    • Organizer
      第88回日本産業衛生学会
    • Place of Presentation
      グランフロント大阪
    • Year and Date
      2015-05-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] 亜鉛欠乏及び過剰食が長寿遺伝子Sirt1の発現に及ぼす影響2015

    • Author(s)
      内匠正太、木戸尊將、関良子、与五沢真吾、須賀万智、柳澤裕之
    • Organizer
      第88回日本産業衛生学会
    • Place of Presentation
      グランフロント大阪
    • Year and Date
      2015-05-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] エコールとブラシニンの併用によるヒト大腸癌由来HT-29細胞の増殖抑制効果の増強2015

    • Author(s)
      与五沢真吾、酒井敏行、柳澤裕之
    • Organizer
      第85回日本衛生学会学術総会
    • Place of Presentation
      ホテルアバローム紀の国
    • Year and Date
      2015-03-27
    • Related Report
      2014 Research-status Report
  • [Presentation] クルクミンの半量体構造をしたデヒドロジンゲロンは、細胞内ROSの増加を伴いつつ、ヒト大腸癌細胞の増殖を抑制する

    • Author(s)
      与五沢真吾、山田恭正、安田周祐、Sun Qi、滝澤香織、酒井敏行
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] 子宮体癌細胞に対する新規HDAC阻害剤とPI3K阻害剤併用による相乗的アポトーシス誘導効果の検討

    • Author(s)
      吉岡崇、与五沢真吾、山田剛司、北脇城、酒井敏行
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Research-status Report
  • [Remarks] 東京慈恵会医科大学~環境保健医学講座

    • URL

      http://www.jikei.ac.jp/academic/course/14_hokeni.html

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
  • [Remarks] 東京慈恵会医科大学大学院医学研究科~環境保健医学

    • URL

      http://www.jikei.ac.jp/univ/gradu/rsch/05_01.html

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
  • [Remarks] 東京慈恵会医科大学環境保健医学講座

    • URL

      http://square.umin.ac.jp/jikphem/

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
  • [Remarks] 東京慈恵会医科大学~環境保健医学講座

    • URL

      http://www.jikei.ac.jp/academic/course/14_hokeni.html

    • Related Report
      2013 Research-status Report
  • [Remarks] 東京慈恵会医科大学大学院医学研究科~環境保健医学

    • URL

      http://www.jikei.ac.jp/univ/gradu/rsch/05_01.html

    • Related Report
      2013 Research-status Report
  • [Remarks] 東京慈恵会医科大学環境保健医学講座

    • URL

      http://square.umin.ac.jp/jikphem/

    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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