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The association among ferruginous body, uncoated fibers, asbestos and non-asbestos fibers in lung tissue

Research Project

Project/Area Number 25460821
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Hygiene and public health
Research InstitutionAichi Medical University

Principal Investigator

Eiji Shibata  愛知医科大学, 医学部, 教授 (90206128)

Co-Investigator(Kenkyū-buntansha) SAKAKIBATA Yoko  愛知教育大学, 保健環境センター, 准教授 (90242891)
Research Collaborator SUZUKI Takayoshi  
HISANAGA Naomi  
SAKAI Kiyoshi  
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords石綿 / 含鉄小体 / 石綿小体 / 位相差顕微鏡 / 肺内石綿濃度 / 剖検肺 / 角閃石系石綿 / ばく露指標 / 石綿関連疾患 / 角閃石 / クリソタイル / 鉄タンパク / 中皮腫
Outline of Final Research Achievements

To demonstrate the correlations between the concentrations of ferruginous body as well as uncoated fiber both of which can be observed with phase-contrast microscope and the concentration of various inorganic fibers including asbestos which requires the observation with TEM or SEM, we measured those indices among Japanese and Korean cases. Though the concentration of ferruginous body in lung tissue is an important index of asbestos exposure, uncoated fibers observed with phase-contrast microscope might be another index especially in such cases with relatively low exposure due to their history of living in a general environment. However, to establish the reliability of uncoated fibers as an index of asbestos exposure, analysis with more cases and from various backgrounds must be carried out.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (18 results)

All 2016 2015 2014 2013 Other

All Int'l Joint Research (1 results) Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (12 results) Book (1 results)

  • [Int'l Joint Research] College of Medicine, Dongguk University/Hoseo University(韓国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] The association among ferruginous body, uncoated fibers, asbestos and non-asbestos fibers in lung tissue in terms of length2016

    • Author(s)
      Takayoshi SUZUKI, Yoko SAKAKIBARA, Naomi HISANAGA, Kiyoshi SAKAI, Il-Je YU, Hyun-Sul LIM, Hiroshige MIKAMO, Hiroshi SENO, Fumio KOBAYASHI and Eiji SHIBATA
    • Journal Title

      Industrial Health

      Volume: 54 Issue: 4 Pages: 370-376

    • DOI

      10.2486/indhealth.2015-0159

    • NAID

      130005253916

    • ISSN
      0019-8366, 1880-8026
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Trends in Asbestos and Non-asbestos Fibre Concentrations in the Lung Tissues of Japanese Patients with Mesothelioma2014

    • Author(s)
      Sakai K, Hisanaga N, Shibata E, Kamijima M, Ichihara G, Takeuchi Y, Nakajima T
    • Journal Title

      Ann Occup Hyg

      Volume: 58 Pages: 103-120

    • DOI

      10.1093/annhyg/met055

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Formation of the nitrative DNA lesion 8-nitroguanine is assocatied with asbestos contents in human lung tissues2014

    • Author(s)
      Hiraku Y, Sakai K, Shibata E, Kamijima M, Hisanaga N, Ma N, Kawanashi S, Murata M
    • Journal Title

      J Occup Health

      Volume: 56 Pages: 186-196

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] アスベストの特性とその健康影響2014

    • Author(s)
      柴田英治
    • Journal Title

      生活と環境

      Volume: 59 Pages: 18-23

    • Related Report
      2014 Research-status Report
  • [Presentation] 胸部X線写真に胸膜肥厚斑を認めない建築業従事者における胸部CT上の胸膜肥厚斑有所見率2015

    • Author(s)
      久永直見、柴田英治、酒井潔、鈴木隆佳、内藤久雄。上島通浩
    • Organizer
      平成27年度日本産業衛生学会東海地方会学会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-11-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] 石綿肺がんとして労災認定された建築業従事者36名の職業歴2015

    • Author(s)
      久永直見、柴田英治、酒井潔、鈴木隆佳、内藤久雄、上島通浩
    • Organizer
      第88回日本産業衛生学会
    • Place of Presentation
      大阪
    • Year and Date
      2015-05-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] 肺内含鉄小体の形状に関する検討 -中皮腫と非石綿関連疾患の比較-2014

    • Author(s)
      鈴木隆佳、榊原洋子、酒井潔、五藤雅博、柴田英治、久永直見、小林章雄
    • Organizer
      平成26年度日本産業衛生学会東海地方会学会
    • Place of Presentation
      津
    • Year and Date
      2014-11-22
    • Related Report
      2014 Research-status Report
  • [Presentation] 建築作業者における石綿の種類別・繊維サイズ別個人曝露濃度の透過型分析電顕法による評価(第2報)2014

    • Author(s)
      酒井潔、久永直見、柴田英治、榊原洋子、鈴木隆佳、上島通浩、那須民江、加藤昌志
    • Organizer
      第87回日本産業衛生学会
    • Place of Presentation
      岡山
    • Year and Date
      2014-05-21 – 2014-05-24
    • Related Report
      2014 Research-status Report
  • [Presentation] 肺内の含鉄小体濃度と石綿・非石綿繊維の長さ別濃度との関係2014

    • Author(s)
      鈴木隆佳、榊原洋子、小宮山みる、酒井潔、兪鉉述、柴田英治、久永直見、小林章雄
    • Organizer
      第87回日本産業衛生学会
    • Place of Presentation
      岡山
    • Year and Date
      2014-05-21 – 2014-05-24
    • Related Report
      2014 Research-status Report
  • [Presentation] ヒト肺組織におけるニトロ化DNA損傷と石綿繊維量の関連および繊維長の影響2014

    • Author(s)
      平工雄介、酒井潔、柴田英治、上島通浩、久永直見、村田真理子
    • Organizer
      第87回日本産業衛生学会
    • Place of Presentation
      岡山
    • Year and Date
      2014-05-21 – 2014-05-24
    • Related Report
      2014 Research-status Report
  • [Presentation] 肺内の含鉄小体濃度と石綿・非石綿繊維の長さ別濃度との関係-中皮腫剖検例と非石綿疾患剖検例での検討-2013

    • Author(s)
      鈴木隆佳、榊原洋子、酒井潔、柴田英治、久永直見、小林章夫
    • Organizer
      第86回日本産業衛生学会
    • Place of Presentation
      松山市
    • Related Report
      2013 Research-status Report
  • [Presentation] 建築作業で曝露された石綿の種類別・繊維サイズ別濃度の分析電子顕微鏡による評価2013

    • Author(s)
      酒井潔、久永直見、柴田英治、榊原洋子、鈴木隆佳、那須民江
    • Organizer
      第86回日本産業衛生学会
    • Place of Presentation
      松山市
    • Related Report
      2013 Research-status Report
  • [Presentation] ブレーキ・クラッチ再生作業における電顕法を用いた石綿曝露測定2013

    • Author(s)
      柴田英治.酒井潔、榊原洋子、久永直見
    • Organizer
      第86回日本産業衛生学会
    • Place of Presentation
      松山市
    • Related Report
      2013 Research-status Report
  • [Presentation] 含鉄小体及び石綿・非石綿繊維濃度の肺葉間の差の検討2013

    • Author(s)
      鈴木隆佳、榊原洋子、酒井潔、柴田英治、久永直見、小林章雄
    • Organizer
      平成25年度日本産業衛生学会東海地方会学会
    • Place of Presentation
      長久手市
    • Related Report
      2013 Research-status Report
  • [Presentation] 左官の石綿含有蛇紋岩使用とそれによる健康影響の防止2013

    • Author(s)
      久永直見、酒井潔、榊原洋子、鈴木隆佳、柴田英治
    • Organizer
      平成25年度日本産業衛生学会東海地方会学会
    • Place of Presentation
      長久手市
    • Related Report
      2013 Research-status Report
  • [Presentation] 肺がん患者の肺内石綿濃度の経年推移2013

    • Author(s)
      酒井潔、久永直見、柴田英治、上島通浩、内藤久雄、市原学、名取雄司、田村昭彦、舟越光彦、五藤雅博、那須民江、加藤昌志
    • Organizer
      平成25年度日本産業衛生学会東海地方会学会
    • Place of Presentation
      長久手市
    • Related Report
      2013 Research-status Report
  • [Book] 胸膜全書2013

    • Author(s)
      久永直見、酒井潔、柴田英治
    • Total Pages
      399
    • Publisher
      医薬ジャーナル社
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2022-01-31  

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