Comparison of the biological impacts of the fluoride compounds by grahical risk visualization map technique

• Project/Area Number: 25460822
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hygiene and public health
• Research Institution: Osaka Medical College
• Principal Investigator: Usuda Kan 大阪医科大学, 医学部, 准教授 (80298752)
• Co-Investigator(Kenkyū-buntansha): Kono Rei 大阪医科大学, 医学部, 助教 (00622573) ; Fujimoto Keiichi 大阪医科大学, 医学部, 講師 (20599740) ; Ueno Takaaki 大阪医科大学, 医学部, 教授 (60252996) ; Watanabe Misuzu 大阪医科大学, 医学部, 講師 (30084924) ; Dote Tomotaro 大阪医科大学, 看護学部, 教授 (10257868) ; Hirotaka Yokoyama 大阪医科大学, 看護学部, 講師 (20550510)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: フッ素化合物 / 微量元素 / リスクアセスメント / 化学物質暴露 / フッ素 / 産業暴露 / 化学物質のリスク評価 / 産業医学 / 職業性暴露 / 化学物質による中毒

Outline of Final Research Achievements

The risk assessment study was conducted using a series of inorganic fluorides. The results reveal that sodium fluoride (NaF), potassium fluoride (KF) and zinc fluoride tetrahydrate (ZnF2.4H2O) can carry the fluoride ion into the bloodstream and that it is excreted via urine more readily than the other compounds tested. These fluorides were assigned the highest risk impact factor. Most of the rare earth fluorides are insoluble in water while those groups 2 and 13 of the periodic table are slightly soluble, so that they do not have a significant negative risk. These findings suggest that the biological impact of fluoride depends on the accompanying counter ion and its solubility.

Research Products

• [Journal Article] Comparison of the Biological Impacts of the Fluoride Compounds by Graphical Risk Visualization Map Technique. (2015)
  • Author(s): Usuda K, Kono R, Ueno T, Ito Y, Dote T, Yokoyama H, Kono K, Tamaki J.
  • Journal Title: Biol Trace Elem Res. Volume: 167 Issue: 1 Pages: 84-90
  • DOI: 10.1007/s12011-015-0278-7
  • Peer Reviewed
• [Journal Article] Risk assessment visualization of rubidium compounds: comparison of renal and hepatic toxicities, in vivo. (2014)
  • Author(s): Usuda K, Kono R, Ueno T, Ito Y, Dote T, Yokoyama H, Kono K, Tamaki J.
  • Journal Title: Biol Trace Elem Res. Volume: 159 Issue: 1-3 Pages: 263-268
  • DOI: 10.1007/s12011-014-9937-3
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Precise Determination of Trace Rubidium in Biological Fluid Using Inductively Coupled Plasma Atomic Emission Spectroscopy (2014)
  • Author(s): Fujita A, Kono K, Usuda K, Shimizu H, Fujimoto K, Kono R, Ohnishi K, Komiyama M, Yuko Nakatsuru Y, Mohiuddin, J Tamaki
  • Journal Title: Bull OMC Volume: 59 Pages: 69-74
  • Peer Reviewed
• [Presentation] フッ素化合物の生体影響とリスク評価に関する研究 (2015)
  • Author(s): 臼田寛、玉置淳子、土手友太郎、横山浩誉、丸山会里、河野公一
  • Organizer: 第25回日本産業衛生学会 産業医・産業看護全国協議会
  • Place of Presentation: 周南市文化会館
  • Year and Date: 2015-09-16