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Nicotinic acid and related enzyme level and risk for cardiovascular disease in epidemiological study among general population

Research Project

Project/Area Number 25460824
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Hygiene and public health
Research InstitutionNational Cardiovascular Center Research Institute (2014-2015)
Hyogo Medical University (2013)

Principal Investigator

Higashiyama Aya  国立研究開発法人国立循環器病研究センター, 研究開発基盤センター, 室長 (20533003)

Co-Investigator(Renkei-kenkyūsha) Okamura Tomonori  慶應義塾大学, 医学部衛生公衆衛生学, 教授 (00324567)
Wakabayashi Ichiro  兵庫医科大学, 医学部環境予防医学, 教授 (70220829)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsビスファチン / メタボリック症候群 / 生活習慣 / 予防 / 冠動脈疾患発症確率 / Nampt / 吹田スコア / ニコチン酸代謝酵素 / 血糖異常 / 動脈硬化 / 循環器疾患予防 / BNP / 左室肥大 / ニコチン酸
Outline of Final Research Achievements

We measured serum visfatin (Nampt) level in 797 community-dwellers aged 40-74 years in Hyogo Prefecture. Nampt has been reported to be high in unstable coronary plaque, and in patients with stroke, traumatic brain injury, and diabetes. However, few studies has investigated the relationship between Nampt level and lifestyle or measured variables in general population. In the multiple regression model after adjusting for sex and age, higher glucose, HbA1c, blood pressure, body mass index (BMI), waist circumference, triglyceride, and lower HDL-cholesterol level were significantly associated with higher Nampt. And higher Nampt was significantly associated with higher probability of 10-year coronary heart disease incidence estimated by Suita Score. In men, Nampt was the highest in current smokers, and the quartiles of Nampt was significantly negatively associated with cardio-ankle vascular index in ANCOVA after adjusting for age and systolic blood pressure.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (6 results)

All 2015 2014 2013

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results,  Acknowledgement Compliant: 2 results) Presentation (3 results)

  • [Journal Article] Association Between Serum Long-Chain n-3 and n-6 Polyunsaturated Fatty Acid Profiles and Glomerular Filtration Rate Assessed by Serum Creatinine and Cystatin C Levels in Japanese Community-Dwellers2015

    • Author(s)
      Higashiyama A, Kubota Y, Marumo M, Konishi M, Yamashita Y, Nishimura K, Fukuda Y, Okamura T, Wakabayashi I.
    • Journal Title

      Journal of Epidemiology

      Volume: 25 Issue: 4 Pages: 303-311

    • DOI

      10.2188/jea.JE20140093

    • NAID

      130005061998

    • ISSN
      0917-5040, 1349-9092
    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serum polyunsaturated fatty acid composition and serum high-sensitivity C-reactive protein levels in healthy Japanese residents: the KOBE study2015

    • Author(s)
      Kubota Y, Higashiyama A, Imano H, Sugiyama D,Kawamura K, Kadota A, Nishimura K, Miyamatsu N, Miyamoto Y, Okamura T.
    • Journal Title

      J Nutr Health Aging

      Volume: 未定 Issue: 7 Pages: 719-728

    • DOI

      10.1007/s12603-015-0497-9

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Serum polyunsaturated fatty acid composition and serum high-sensitivity C-reactive protein levels in healthy Japanese residents: the KOBE study.2015

    • Author(s)
      Kubota Y, Higashiayama A, Imano H, Sugiyama D, Kawamura K, Kadota A, Nishimura K, Miyamatsu N, Miyamoto Y, Okamura T.
    • Journal Title

      Journal of Nutrition, Health and Aging

      Volume: in press

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 地域住民における喫煙状況別の動脈硬化・下肢動脈狭窄のスクリーニング:篠山研究2015

    • Author(s)
      小西雅美、大上理恵、久保田芳美、東山綾、丸尾幹雄、山下好子、岡村智教、宮本恵宏、若林一郎
    • Organizer
      第74回日本公衆衛生学会総会
    • Place of Presentation
      長崎
    • Year and Date
      2015-11-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] 血中n-3/n-6系多価不飽和脂肪酸指標と推定糸球体ろ過量の関係2014

    • Author(s)
      小西雅美、東山綾、久保田芳美、丸茂幹雄、山下好子、西村邦宏、福田能啓、岡村智教、若林一郎
    • Organizer
      第73回日本公衆衛生学会学術総会
    • Place of Presentation
      宇都宮
    • Year and Date
      2014-11-05 – 2014-11-07
    • Related Report
      2014 Research-status Report
  • [Presentation] 降圧薬を服用していない吹田市一般住民集団における血中BNP濃度と心エコーで測定した左室心筋重量との関連2013

    • Author(s)
      東山綾、渡邉至、小久保喜弘、岡村智教、岡山明、宮本恵宏
    • Organizer
      第36回日本高血圧学会総会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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