The development of new indicators and preventive methods for early detection of the tendency of autism: the association between food and allergy

• Project/Area Number: 25460830
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hygiene and public health
• Research Institution: Kansai University of Welfare Sciences
• Principal Investigator: SAGARA Takiko 関西福祉科学大学, 健康福祉学部, 教授 (30249164)
• Co-Investigator(Kenkyū-buntansha): 中村 裕之 金沢大学, 医学系, 教授 (30231476) ; 三辺 義雄 金沢大学, 医学系, 教授 (60181947) ; 人見 嘉哲 金沢大学, 医学系, 准教授 (70231545) ; 神林 康弘 金沢大学, 医学系, 講師 (20345630)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: アレルギー / 自閉症 / 体重 / アトピー性皮膚炎 / 気管支喘息 / 食 / 小児 / 食育 / 栄養 / 環境 / コホート / 予防

Outline of Final Research Achievements

We performed a cross-sectional survey to examine the prevalence of symptoms of eczema, asthma, rhinoconjunctivitis and autism spectrum disorder and to elucidate the associations between them. The participants were 337 children aged 3-6 years attending kindergarten or nursery school in Shika town, Japan. Autism spectrum feature was scored on the Social Communication Questionnaire (SCQ). The prevalence of symptoms was 11.3% for eczema, 14.8% for asthma, and 5.3% for rhinoconjunctivitis. A total of 15 children (4.5%) had the SCQ score of 11 points or over. The logistic regression indicated that eczema symptom was significantly associated with the SCQ score of 11 points or over. The association persisted after adjusted for age, gender, and BMI. Moreover, asthma symptom was significantly associated with boy and overweight. The result suggested that high SCQ score, which implies autism spectrum traits, might be an important risk factor for eczema.

Research Products

• [Journal Article] Prevalence of Chronic Pain, Especially Headache, and Relationship with Health-Related Quality of Life in Middle-Aged Japanese Residents. (2016)
  • Author(s): Mitoma J, Kitaoka M, Asakura H, Anyenda EO, Hori D, Nguyen TT, Hamagishi T, Hayashi K, Suzuki F, Shimizu Y, Tsujiguchi H, Kambayashi Y, Hibino Y, Konoshita T, Sagara T, Shibata A, Nakamura H
  • Journal Title: Health Volume: 8 Issue: 01 Pages: 116-124
  • DOI: 10.4236/health.2016.81014
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Preventive effects of ramelteon on delirium: a randomized placebo-controlled trial (2014)
  • Author(s): Hatta K, Kishi Y, Wada K, Takeuchi T, Odawara T, Usui C, Nakamura H; DELIRIA-J Group
  • Journal Title: JAMA Psychiatry Volume: 71 Issue: 4 Pages: 397-403
  • DOI: 10.1001/jamapsychiatry.2013.3320
  • Peer Reviewed
• [Journal Article] Theobromine, the primary methylxanthine found in Theobroma cacao, prevents malignant glioblastoma proliferation by negatively regulating phosphodiesterase-4, extracellular signal-regulated kinase, Akt/mammalian target of rapamycin kinase, and nuclear factor-kappa B (2014)
  • Author(s): Sugimoto N, Miwa S, Hitomi Y, Nakamura H, Tsuchiya H, Yachie A
  • Journal Title: Nutr Cancer Volume: 66(3) Issue: 3 Pages: 419-23
  • DOI: 10.1080/01635581.2013.877497
  • Peer Reviewed
• [Journal Article] Consumption of green tea, but not black tea or coffee, is associated with reduced risk of cognitive decline. (2014)
  • Author(s): Noguchi-Shinohara M, Yuki S, Dohmoto C, Ikeda Y, Samuraki M, Iwasa K, Yokogawa M, Asai K, Komai K, Nakamura H, Yamada M.
  • Journal Title: PLoS One Volume: 14;9(5) Issue: 5 Pages: e96013-e96013
  • DOI: 10.1371/journal.pone.0096013
  • Peer Reviewed
• [Journal Article] A novel coronary active perfusion system using a conventional intra-aortic balloon pump for off-pump coronary artery bypass grafting. (2014)
  • Author(s): Kiuchi R, Tomita S, Yamaguchi S, Nishida Y, Ohtake H, Nakamura H, Watanabe G
  • Journal Title: J Thorac Cardiovasc Surg Volume: 48(1) Issue: 1 Pages: 304-310
  • DOI: 10.1016/j.jtcvs.2013.11.049
  • Peer Reviewed
• [Journal Article] High sensitivity of late gadolinium enhancement for predicting microscopic myocardial scarring in biopsied specimens in hypertrophic cardiomyopathy. (2014)
  • Author(s): Konno T，Hayashi K，Fujino N，Nagata Y，Hodatsu A，Masuta E，Sakata K，Nakamura H，Kawashiri M，Yamagishi M.
  • Journal Title: PLoS One. Volume: 9 Issue: 7 Pages: e101465-e101465
  • DOI: 10.1371/journal.pone.0101465
  • NAID: 120006460361
  • Peer Reviewed / Open Access
• [Journal Article] Effects of Asian dust on daily cough occurrence in patients with chronic cough: A panel study. (2014)
  • Author(s): Higashi T, Kambayashi Y, Ohkura N, Fujimura M, Nakai S, Honda Y, Saijoh K, Hayakawa K, Kobayashi F, Michigami Y, Anyenda EO, Hitomi Y, Nakamura H.
  • Journal Title: Atmospheric Environment Volume: 92 Pages: 506-513
  • DOI: 10.1016/j.atmosenv.2014.04.034
  • NAID: 120005463354
  • Peer Reviewed / Open Access
• [Journal Article] Clinical impacts of albuminuria and glomerular filtration rate on renal, cardiovascular events, and all-cause mortality in Japanese patients with type 2 diabetes. (2014)
  • Author(s): Wada T, Haneda M, Furuichi K, Babazono T, Yokoyama H, Iseki K, Araki SI, Ninomiya T, Hara S, Suzuki Y, Iwano M, Kusano E, Moriya T, Satoh H, Nakamura H, Shimizu M, Toyama T, Hara A, Makino H; The Research Group of Diabetic Nephropathy, Ministry of Health, Labour, and Welfare of Japan
  • Journal Title: Clin Exp Nephrol Volume: - Issue: 4 Pages: 613-620
  • DOI: 10.1007/s10157-013-0879-4
  • NAID: 120005411654
  • Peer Reviewed
• [Journal Article] Erratum to: Clinical impact of albuminuria and glomerular filtration rate on renal and cardiovascular events, and all-cause mortality in Japanese patients with type 2 diabetes. (2014)
  • Author(s): Wada T, Haneda M, Furuichi K, Babazono T, Yokoyama H, Iseki K, Araki SI, Ninomiya T, Hara S, Suzuki Y, Iwano M, Kusano E, Moriya T, Satoh H, Nakamura H, Shimizu M, Toyama T, Hara A, Makino H, The Research Group of Diabetic Nephropathy, Ministry of Health, Labour, and Welfare of Japan.
  • Journal Title: Clin Exp Nephrol Volume: 18(4) Issue: 4 Pages: 621-622
  • DOI: 10.1007/s10157-013-0931-4
  • Peer Reviewed
• [Journal Article] Long-term Heat Exposure Prevents Hypoxia-Induced Apoptosis in Mouse Fibroblast Cells (2014)
  • Author(s): Sugimoto N, Shido O, Matsuzaki K, Katakura M, Hitomi Y, Tanaka M, Sawaki T, Fujita Y, Kawanami T, Masaki Y, Okazaki T, Nakamura H, Koizumi S, Yachie A and Umehara H
  • Journal Title: Cell biochemistry and biophysics Volume: (in press) Issue: 1 Pages: 301-7
  • DOI: 10.1007/s12013-014-9912-9
  • Peer Reviewed
• [Journal Article] Epidemiological link between wheat allergy and exposure to hydrolyzed wheat protein in facial soap. (2014)
  • Author(s): Fukutomi Y, Taniguchi M, Nakamura H, Akiyama K.
  • Journal Title: Allergy. Volume: 69(10) Issue: 10 Pages: 1405-1411
  • DOI: 10.1111/all.12481
  • Peer Reviewed
• [Journal Article] Exacerbation of daily cough and allergic symptpms in adult patients with chronic cough by Asian dust: A hospital-based study in Kanazawa (2014)
  • Author(s): Higashi T, Kambayashi Y, Ohkura N, Fujimura M, Nakanishi S, Yoshizaki T, Saijoh K, Hayakawa K, Kobayashi F, Michigami Y, Hitomi Y, and Nakamura H
  • Journal Title: Atmospheric Environment Volume: in press Pages: 537-543
  • DOI: 10.1016/j.atmosenv.2014.01.041
  • Peer Reviewed / Open Access
• [Presentation] 幼児の心の発達と生活環境因子について (2017)
  • Author(s): 相良多喜子
  • Organizer: 第６４回日本栄養改善学会学術総会
  • Place of Presentation: アスティとくしま（徳島県）
• [Presentation] 女子大学生の疲労自覚症状に関わる要因の検討 (2015)
  • Author(s): 相良多喜子
  • Organizer: 第62回日本栄養改善学会学術総会
  • Place of Presentation: 福岡国際会議場（福岡県）
  • Year and Date: 2015-09-24
• [Presentation] 小中学校児童生徒の自閉症傾向は、体型および栄養状態と関連する (2015)
  • Author(s): 堀大介、辻口博聖、神林康弘、濱岸利夫、北岡政美、三苫純子、朝倉大貴、鈴木史彦、Anyenda Enoch Olando、Nguyen Thi Thu Thao、中村剛、木戸康人、能登裕幸、荒舩丈一、清水由加里、林宏一郎、日比野由利、柴田亜樹、相良多喜子、笹原信一朗、松崎一葉、中村裕之
  • Organizer: 第25回体力・栄養・免疫学会大会
  • Place of Presentation: 帝京科学大学（東京）
  • Year and Date: 2015-08-22
• [Presentation] 生活習慣および精神的健康度と健診受診行動との関連 (2015)
  • Author(s): 辻口博聖、堀大介、神林康弘、朝倉大貴、北岡政美、三苫純子, Anyenda Enoch Olando, Nguyen Thi Thu Thao、濱岸利夫、中村剛、木戸康人、能登裕幸、鈴木史彦、荒舩丈一、清水由加里、林宏一郎、日比野由利、柴田亜樹、相良多喜子、中村裕之
  • Organizer: 第13回日本予防医学会学術総会
  • Place of Presentation: フレンドパーク石川(石川県)
  • Year and Date: 2015-06-20
• [Presentation] 精神的健康度と性，年代，生活習慣要因の関連－金沢市一般住民の横断調査 (2015)
  • Author(s): 堀大介、辻口博聖、神林康弘、濱岸利夫、北岡政美、三苫純子、朝倉大貴、鈴木史彦, Anyenda Enoch Olando, Nguyen Thi Thu Thao、中村 剛、木戸康人、能登裕幸、荒舩丈一、清水由加里、林宏一郎、日比野由利、柴田亜樹、相良多喜子、笹原信一朗、松崎一葉、中村裕之
  • Organizer: 第13回日本予防医学会学術総会
  • Place of Presentation: フレンドパーク石川(石川県)
  • Year and Date: 2015-06-20
• [Presentation] INVESTIGATION ABOUT THE BREAKFAST INTAKE COMPARISON BETWEEN DIETITIAN COURSE STUDENT AND THE OTHER STUDENT (2014)
  • Author(s): Naomi Katayama, Chizuko Hotta, Takiko Sagara
  • Organizer: 第６回アジア栄養士会議
  • Place of Presentation: 台北市国際会議場(台湾)
  • Year and Date: 2014-08-23
• [Presentation] 児童生徒における食生活実態調査の検討 (2013)
  • Author(s): 相良多喜子、桑守豊美
  • Organizer: 第60回日本栄養改善学会学術総会
  • Place of Presentation: 神戸国際会議場
• [Presentation] 中学生における食に関する指導の実践 (2013)
  • Author(s): 相良多喜子
  • Organizer: 第12回日本栄養改善学会近畿支部学術総会
  • Place of Presentation: 千里金蘭大学
• [Book] 給食の運営 給食計画・実務編 第5版 (2016)
  • Author(s): 富岡和夫、笹田陽子、相良多喜子、佐藤玲子、杉本温美、高野美幸、西川貴子
  • Total Pages: 272
  • Publisher: 医歯薬出版
• [Book] 栄養教育論―栄養の指導― (2016)
  • Author(s): 蕨迫栄美子、関口紀子、相良多喜子、石井幸江、加藤由美子、和田涼子、宇和川小百合
  • Total Pages: 259
  • Publisher: 学建書院
• [Book] 「教育と医学」子どもの心の発達と食育の科学 (2016)
  • Author(s): 相良多喜子
  • Total Pages: 96
  • Publisher: 慶應義塾大学出版
• [Book] 学内給食経営管理実習のためのおいしい食事のコーディネート（第２版） (2015)
  • Author(s): 木村友子、井上明美、長澤伸江、松井元子、相良多喜子、他４名
  • Total Pages: 171
  • Publisher: 医歯薬出版株式会社
• [Book] 栄養士課程実習ノート（第６版） (2015)
  • Author(s): 相良多喜子、熊沢昭子、間瀬友子、北川公子、片山直美
  • Total Pages: 110
  • Publisher: 医歯薬出版株式会社
• [Book] カレント給食経営管理論（第２版） (2015)
  • Author(s): 宮澤節子、松井元子、相良多喜子、尾木千恵美、加賀谷みえ子、河合潤子、他５名
  • Total Pages: 241
  • Publisher: 株式会社建帛社
• [Book] 五訂 ライフステージの栄養学 理論と実習 (2015)
  • Author(s): 桑守豊美、志塚ふじ子、小川宣子、相良多喜子、他５名
  • Total Pages: 265
  • Publisher: 株式会社みらい