| Project/Area Number |
25460832
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hygiene and public health
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| Research Institution | Osaka Prefectural Institute of Public Health |
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Principal Investigator |
Sakon Naomi 大阪府立公衆衛生研究所, その他部局等, 研究員 (50291216)
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| Co-Investigator(Kenkyū-buntansha) |
Kanbayashi Daiki 大阪府立公衆衛生研究所, 感染症部・ウイルス課, 研究員 (50622560)
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| Co-Investigator(Renkei-kenkyūsha) |
Nakata Keiko 大阪府立公衆衛生研究所, 感染症部・ウイルス課, 主任研究員 (50516747)
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| Research Collaborator |
KOMANO Jun 国立病院機構名古屋医療センター臨床研究センター, 統括診療部, 臨床検査科長 (60356251)
NAKAMURA Shota 大阪大学, 微生物病研究所, 特任教授 (90432434)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | ノロウイルス / 遺伝子型 / 変異 / 再感染 / 免疫 / 不顕性感染 / norovirus / mutation / deep sequencing / 流行 |
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| Outline of Final Research Achievements |
The characteristics of natural immunity against norovirus were analyzed by long-term molecular epidemiological study involving systematic surveillance covering all age groups and routes of infection was performed in the province of Osaka, Japan.There was evidence at both the facility and individual levels that genotype-specific herd immunity lasted long enough to influence the endemic norovirus genotype in the next season. Thus, norovirus circulates through human populations in a uniquely dynamic fashion. We contribute to the basic knowledge of the norovirus vaccine development.
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