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Investigation of the prevalence of macrolide-resistant mycoplasmal diseases, the susceptibility for antibiotics and the clinical features associated with the resistant bacteria infection.

Research Project

Project/Area Number 25460834
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Hygiene and public health
Research InstitutionOsaka Prefectural Institute of Public Health

Principal Investigator

Katsukawa Chihiro  大阪府立公衆衛生研究所, その他部局等, 研究員 (20183725)

Co-Investigator(Kenkyū-buntansha) TAKAHASHI Kazuo  国際医療福祉大学, 大学病院検査部, 教授 (10171472)
Research Collaborator MIZUTANI Kayoko  
UMEDA Kaoru  
ASAI Sadasaburo  
ARAI Kazuko  
KOHDERA Urara  
KAJI Katsushi  
KUSHIBIKI Chieko  
SHIOMI Masashi  
TAKEDA Yoshihiro  
NAKA Atsuko  
NAKANO Keiji  
MATSUSHITA Tohru  
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords肺炎マイコプラズマ / 薬剤感受性 / マクロライド系薬剤耐性 / 遺伝子型別 / マイコプラズマ / 薬剤耐性 / マクロライド / GENECUBE / P1遺伝子型別 / MLVA法 / P1遺伝子 / 23SrRNA
Outline of Final Research Achievements

It was found that rapid nucleic acid-based diagnosis for the detection of Mycoplasma pneumoniae and rapid susceptibility testing for macrolides (Decision of the therapeutic antibiotics) led to reduction of the symptom, shortening of the duration of treatment at the time of M. pneumoniae infection. The macrolide-resistant mycoplasma suddenly had decreased in 2015 during an investigation period from 2013 through 2015. The major cause was change of prevalence types from macrolide-resistant type I bacteria to macrolide-sensitive type II bacteria. It was recognized that the violent change of the resistance ratio was found with change of the prevalent types.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (10 results)

All 2016 2015 2014 2013

All Journal Article (4 results) (of which Open Access: 2 results,  Acknowledgement Compliant: 1 results,  Peer Reviewed: 3 results) Presentation (6 results)

  • [Journal Article] マイコプラズマの遺伝子型別2016

    • Author(s)
      勝川千尋 他
    • Journal Title

      日本マイコプラズマ学会雑誌

      Volume: 42 Pages: 54-56

    • Related Report
      2015 Annual Research Report
    • Open Access / Acknowledgement Compliant
  • [Journal Article] Laboratory-based surveillance of pertussis using multitarget real-time PCR in Japan: evidence for Bordetella pertussis infection in preteens and teens.2015

    • Author(s)
      Kamachi K., Katsukawa C., et al.
    • Journal Title

      New Microbes New Infect.

      Volume: 8 Pages: 70-74

    • DOI

      10.1016/j.nmni.2015.10.001

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of streptococcal toxic shock-like syndrome caused by group B streptococcus in adults in Japan between 2009 and 2013.2015

    • Author(s)
      2.Ikebe T, Chiba K, Shima T, Masuda C, Okuno R, Ohya H, Ogata K, Katsukawa C, Kawahara R, Tominaga K, Yabata J, Tada Y, Okabe N, Watanabe H, Chang B, Ogawa M, Ohnishi M, the Working group for beta-hemolytic streptococci in Japan.
    • Journal Title

      J Infection Chemotherpy

      Volume: 21 Issue: 3 Pages: 207-211

    • DOI

      10.1016/j.jiac.2014.12.002

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Increased prevalence of group A streptococcus isolates in streptococcal toxic shock syndrome cases in Japan from 2010–2012.2015

    • Author(s)
      1.Ikebe T, Tominaga K, Shima T, Okuno R, Kubota H, Ogata K, Chiba K, Katsukawa C, Ohya H, Tada Y, Okabe N, Watanabe H, Ogawa M, Ohnishi M, Working Group for Beta-hemolytic Streptococci in Japan.
    • Journal Title

      Epidemiology Infection

      Volume: 143 Issue: 4 Pages: 864-872

    • DOI

      10.1017/s0950268814001265

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] Mycoplasma amphoriforme の侵淫度調査2016

    • Author(s)
      勝川千尋 他
    • Organizer
      第43回日本マイコプラズマ学会
    • Place of Presentation
      長崎
    • Year and Date
      2016-06-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] マイコプラズマの遺伝子型別2015

    • Author(s)
      勝川千尋 他
    • Organizer
      第42回日本マイコプラズマ学会
    • Place of Presentation
      東京
    • Year and Date
      2015-05-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] マイコプラズマ感染患者からの菌分離および分離菌の薬剤感受性2015

    • Author(s)
      勝川千尋、水谷香代子、高橋和郎
    • Organizer
      第26回日本臨床微生物学会総会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2015-01-31 – 2015-02-01
    • Related Report
      2014 Research-status Report
  • [Presentation] 百日咳の細菌学的検査精度向上に関する多方面からの検討2014

    • Author(s)
      勝川千尋、櫛引千恵子、西戸温美、蒲地一成
    • Organizer
      日本臨床微生物学会
    • Place of Presentation
      名古屋国際会議場
    • Related Report
      2013 Research-status Report
  • [Presentation] 百日咳の診断における培養検査と遺伝子検査の有用性の検討2014

    • Author(s)
      勝川千尋、梅田薫、蒲地一成
    • Organizer
      日本細菌学会
    • Place of Presentation
      タワーホール船堀
    • Related Report
      2013 Research-status Report
  • [Presentation] 小児のマクロライド耐性マイコプラズマ肺炎の臨床像の検討2013

    • Author(s)
      高野智子、田尻仁、高橋和郎
    • Organizer
      日本感染症学会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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