Investigation of the prevalence of macrolide-resistant mycoplasmal diseases, the susceptibility for antibiotics and the clinical features associated with the resistant bacteria infection.
| Project/Area Number |
25460834
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hygiene and public health
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| Research Institution | Osaka Prefectural Institute of Public Health |
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Principal Investigator |
Katsukawa Chihiro 大阪府立公衆衛生研究所, その他部局等, 研究員 (20183725)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Kazuo 国際医療福祉大学, 大学病院検査部, 教授 (10171472)
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| Research Collaborator |
MIZUTANI Kayoko
UMEDA Kaoru
ASAI Sadasaburo
ARAI Kazuko
KOHDERA Urara
KAJI Katsushi
KUSHIBIKI Chieko
SHIOMI Masashi
TAKEDA Yoshihiro
NAKA Atsuko
NAKANO Keiji
MATSUSHITA Tohru
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 肺炎マイコプラズマ / 薬剤感受性 / マクロライド系薬剤耐性 / 遺伝子型別 / マイコプラズマ / 薬剤耐性 / マクロライド / GENECUBE / P1遺伝子型別 / MLVA法 / P1遺伝子 / 23SrRNA |
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| Outline of Final Research Achievements |
It was found that rapid nucleic acid-based diagnosis for the detection of Mycoplasma pneumoniae and rapid susceptibility testing for macrolides (Decision of the therapeutic antibiotics) led to reduction of the symptom, shortening of the duration of treatment at the time of M. pneumoniae infection. The macrolide-resistant mycoplasma suddenly had decreased in 2015 during an investigation period from 2013 through 2015. The major cause was change of prevalence types from macrolide-resistant type I bacteria to macrolide-sensitive type II bacteria. It was recognized that the violent change of the resistance ratio was found with change of the prevalent types.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] Evaluation of streptococcal toxic shock-like syndrome caused by group B streptococcus in adults in Japan between 2009 and 2013.2015
Author(s)
2.Ikebe T, Chiba K, Shima T, Masuda C, Okuno R, Ohya H, Ogata K, Katsukawa C, Kawahara R, Tominaga K, Yabata J, Tada Y, Okabe N, Watanabe H, Chang B, Ogawa M, Ohnishi M, the Working group for beta-hemolytic streptococci in Japan.
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Journal Title
J Infection Chemotherpy
Volume: 21
Issue: 3
Pages: 207-211
DOI
Related Report
Peer Reviewed
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[Journal Article] Increased prevalence of group A streptococcus isolates in streptococcal toxic shock syndrome cases in Japan from 2010–2012.2015
Author(s)
1.Ikebe T, Tominaga K, Shima T, Okuno R, Kubota H, Ogata K, Chiba K, Katsukawa C, Ohya H, Tada Y, Okabe N, Watanabe H, Ogawa M, Ohnishi M, Working Group for Beta-hemolytic Streptococci in Japan.
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Journal Title
Epidemiology Infection
Volume: 143
Issue: 4
Pages: 864-872
DOI
Related Report
Peer Reviewed
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