Dynamics of Pneumococcal carriage and emergence of high virulence clone after introduction of vaccine in Japan
| Project/Area Number |
25460835
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hygiene and public health
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| Research Institution | Osaka Prefectural Institute of Public Health |
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Principal Investigator |
Kawahara Ryuji 大阪府立公衆衛生研究所, その他部局等, 主任研究員 (10332454)
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| Co-Investigator(Kenkyū-buntansha) |
TAKEUCHI Hajime 佛教大学, 社会福祉学部, 教授 (30552806)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 肺炎球菌 / ワクチン / 保菌 / 侵襲性感染症 / 侵襲性肺炎球菌感染症 / 薬剤耐性 / 遺伝子型 / IPD / 病原因子 |
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| Outline of Final Research Achievements |
We investigated the impact of pneumococcal vaccine on carriage of Streptococcus pneumoniae and emergence of a high virulent clone in Japan. While the carriage rate didn't change than previous studies, the rate of vaccine-serotypes and non-vaccine-serotypes decreased and increase respectively. Furthermore, the result showed relatedness of serotype 15A, most frequently isolated in the study, between carriage and invative pneumococcal disease strains. Since most of the 15A strains were identical with Sweden15A-25, it is suggested that the 15A clone might be epidemic clone in the near future.
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Report
(4 results)
Research Products
(5 results)
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[Journal Article] 2013年度の侵襲性肺炎球菌感染症の患者発生動向と成人患者由来の原因菌の血清型分布2014
Author(s)
河原隆二, 青柳哲史, 高橋弘毅, 武田博明, 田邊嘉也, 笠原 敬, 西順一郎, 藤田次郎, 丸山貴也, 山崎一美, 横山彰仁, 渡邊浩, 牧野友彦, 高橋琢理, 大日康史, 松井珠乃, 砂川富正, 石岡大成, 奥野英雄, 佐藤 弘, 新井 智, 木村博一, 多屋馨子, 大石和徳, 常 彬, 大西 真, 金城雄樹
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Journal Title
病原微生物検出情報
Volume: 35
Pages: 179-181
Related Report
Open Access
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