| Project/Area Number |
25460872
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | Kagoshima University |
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Principal Investigator |
OGATA MAMORU 鹿児島大学, 医歯学域医学系, 教授 (10152373)
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| Co-Investigator(Kenkyū-buntansha) |
HAYASHI TAKAHITO 鹿児島大学, 医歯学域医学系, 講師 (40512497)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | 社会医学 / 身体的虐待 / 好中球浸潤 / 肺胞マクロファージ / HMGB1 / TLR4 / NF-kB / MMPs / 高齢者虐待 / 免疫組織化学 / MMP2 / MMP9 / HMGB-1 / iNOS / アポトーシス |
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| Outline of Final Research Achievements |
In this study, we demonstrated immunohistochemically that neutrophil infiltrations into multiple organs, particularly into the lungs obtained from abused elderly and child autopsy cases are induced by HMGB1-TLR4-NF-kB signals in the resident alveolar macrophages. In those cases, alveolar macrophages in addition to infiltrated neutrophils can also release inflammatory mediators such as MMP9 and iNOS, resulting in the tissue injury. We could elucidate the pathophysiology of the neutrophil infiltrations into multiple organs due to physical abuse, and it may be useful as a new complementary diagnostic indicator of physical abuse.
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