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Postmortem serum thyroid hormones as possible markers of asphyxial death in forensic autopsy

Research Project

Project/Area Number 25460876
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Legal medicine
Research InstitutionOsaka City University (2015)
Tottori University (2013-2014)

Principal Investigator

Ishikawa Takaki  大阪市立大学, 大学院医学研究科, 教授 (50381984)

Co-Investigator(Kenkyū-buntansha) MICHIUE Tomomi  大阪市立大学, 大学院医学研究科, 准教授 (00529240)
MAEDA Hitoshi  大阪市立大学, 大学院医学研究科, 名誉教授 (20135049)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2014: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2013: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Keywords低酸素 / 虚血 / 頭部外傷 / 甲状腺ホルモン / 視床下部 / 下垂体 / 甲状腺 / 法医病理学 / 低酸素・虚血 / 窒息 / 甲状腺関連ホルモン
Outline of Final Research Achievements

The present study investigated postmortem serum levels of thyroid related hormone (T3, T4, Tg, and TSH) in asphyxia-related deaths. Bilateral cardiac and iliac venous blood samples of forensic autopsy cases were collected. The causes of death consisted of mechanical asphyxia, acute blunt head injury death, drowning, fire fatality, and acute cardiac death (ACD). Serum T3 and T4 were higher in mechanical asphyxia and acute blunt head injury death. With regard to asphyxia-related death, serum T4 was higher in mechanical asphyxia than in ACD, and T3 showed similar findings; however, the elevations were not significant in fire fatality or drowning. There was no difference between the causes of death and serum Tg. These findings were independent of the serum TSH level. Histology of the thyroid gland demonstrated tissue damage in mechanical asphyxia and acute blunt head injury deaths. These observations suggest a rapid increase of serum thyroid hormones due to advanced hypoxia.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (48 results)

All 2016 2015 2014 2013

All Journal Article (22 results) (of which Peer Reviewed: 21 results,  Open Access: 14 results,  Acknowledgement Compliant: 10 results) Presentation (22 results) (of which Invited: 2 results) Book (4 results)

  • [Journal Article] Possible application of CT morphometry of the calcaneus and talus in forensic anthropological identification.2016

    • Author(s)
      Inamori-Kawamoto O, Ishikawa T, Michiue T, Mustafa AM, Sogawa N, Kanou T, Oritani S, Maeda H.
    • Journal Title

      Int J Legal Med

      Volume: 130 Issue: 2 Pages: 575-85

    • DOI

      10.1007/s00414-015-1258-3

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Non specific drug distribution in an autopsy case report of fatal caffeine intoxication.2015

    • Author(s)
      Takaki Ishikawa, Isao Yuasa, Minoru Endoh
    • Journal Title

      Legal Medicine

      Volume: 17 Issue: 6 Pages: 535-538

    • DOI

      10.1016/j.legalmed.2015.11.002

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Contribution of forensic autopsy to scene reconstruction in mass fire casualties: A case of alleged arson on a floor consisting of small compartments in a building.2015

    • Author(s)
      Michiue T, Ishikawa T, Oritani S, Maeda H
    • Journal Title

      Leg Med (Tokyo)

      Volume: 17 Issue: 1 Pages: 43-7

    • DOI

      10.1016/j.legalmed.2014.09.004

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Postmortem CT morphometry of great vessels with regard to the cause of death for investigating terminal circulatory status in forensic autopsy.2015

    • Author(s)
      Sogawa N, Michiue T, Ishikawa T, Inamori-Kawamoto O, Oritani S, Maeda H.
    • Journal Title

      Int J Legal Med

      Volume: 129 Issue: 3 Pages: 551-558

    • DOI

      10.1007/s00414-014-1075-0

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Postmortem CT morphometry with a proposal of novel parameters for sex discrimination of the mandible using Japanese adult data.2015

    • Author(s)
      Kano T, Oritani S, Michiue T, Ishikawa T, Hishmat AM, Sogawa N, Inamori-Kawamoto O, Maeda H
    • Journal Title

      Leg Med (Tokyo)

      Volume: 17 Issue: 3 Pages: 167-171

    • DOI

      10.1016/j.legalmed.2014.12.009

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Efficacy of drug screening in forensic autopsy: Retrospective investigation of routine toxicological findings.2015

    • Author(s)
      Tominaga M, Michiue T, Inamori-Kawamoto O, Hishmat AM, Oritani S, Takama M, Ishikawa T, Maeda H
    • Journal Title

      Leg Med (Tokyo)

      Volume: 17 Issue: 3 Pages: 172-176

    • DOI

      10.1016/j.legalmed.2015.01.001

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Evaluation of postmortem drug concentrations in cerebrospinal fluid compared with blood and pericardial fluid.2015

    • Author(s)
      Tominaga M, Michiue T, Ishikawa T, Inamori-Kawamoto O, Oritani S, Maeda H
    • Journal Title

      Forensic Sci Int

      Volume: 254 Pages: 118-125

    • DOI

      10.1016/j.forsciint.2015.07.005

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Cardiac biomarkers in blood, and pericardial and cerebrospinal fluids of forensic autopsy cases: A reassessment with special regard to postmortem interval.2015

    • Author(s)
      Chen JH, Inamori-Kawamoto O, Michiue T, Ikeda S, Ishikawa T, Maeda H
    • Journal Title

      Leg Med (Tokyo)

      Volume: 17 Issue: 5 Pages: 343-350

    • DOI

      10.1016/j.legalmed.2015.03.007

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Virtual CT morphometry of lower limb long bones for estimation of the sex and stature using postmortem Japanese adult data in forensic identification.2015

    • Author(s)
      Hishmat AM, Michiue T, Sogawa N, Oritani S, Ishikawa T, Fawzy IA, Hashem MA, Maeda H
    • Journal Title

      Int J Legal Med.

      Volume: 129 Issue: 5 Pages: 1173-1182

    • DOI

      10.1007/s00414-015-1228-9

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Investigation of Japanese-specific alleles: Most are of Jomon lineage2015

    • Author(s)
      Yuasa I, Umetsu K, Adachi N, Matsusue A, Nakayashiki N, Fujihara J, Akane A, Harihara S, Jin F, Ishikawa T
    • Journal Title

      Leg Med (Tokyo)

      Volume: 17 Issue: 1 Pages: 52-55

    • DOI

      10.1016/j.legalmed.2014.08.006

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comprehensive investigation of postmortem glucose levels in blood and body fluids with regard to the cause of death in forensic autopsy cases.2015

    • Author(s)
      Chen JH, Michiue T, Inamori-Kawamoto O, Ikeda S, Ishikawa T, Maeda H.
    • Journal Title

      Leg Med (Tokyo).

      Volume: 17 Issue: 6 Pages: 475-482

    • DOI

      10.1016/j.legalmed.2015.08.004

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 日本人特異的遺伝子からみた日本人らしさ:琉球人が和人より日本人らしい.2015

    • Author(s)
      湯浅 勲,遠藤 実,石川隆紀,梅津和夫,安達 登
    • Journal Title

      DNA多型

      Volume: 23 Pages: 125-127

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 神経性無食欲症の2剖検例―内分泌系および中枢神経系の変化について―.2015

    • Author(s)
      谷 直人,道上知美,陳 建華,石川隆紀
    • Journal Title

      法医病理

      Volume: 21 Pages: 83-90

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Postmortem urinary catecholamine levels with regard to the cause of death.2014

    • Author(s)
      Ishikawa T, Inamori-Kawamoto O, Quan L, Michiue T, Chen JH, Wang Q, Zhu BL, Maeda H.
    • Journal Title

      Legal Medicine

      Volume: 16 Issue: 6 Pages: 344-349

    • DOI

      10.1016/j.legalmed.2014.07.006

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Does methanphetamine affect bone metabolism?2014

    • Author(s)
      Tomita M, Katsuyama H, Watanabe Y, Okuyama T, Fushimi S, Ishikawa T, Nata M, Miyamoto O.
    • Journal Title

      Toxicology

      Volume: 319 Pages: 63-68

    • DOI

      10.1016/j.tox.2014.01.014

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular pathology of brain matrix metalloproteases, claudin5, and aquaporins in forensic autopsy cases with special regard to methamphetamine intoxication.2014

    • Author(s)
      Wang Q, Ishikawa T, Michiue T, Zhu BL, Guan DW, Maeda H.
    • Journal Title

      International Journal of Legal Medicine

      Volume: 128 Issue: 3 Pages: 469-474

    • DOI

      10.1007/s00414-014-0972-6

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Forensic molecular pathology: its impacts on routine work, education and training.2014

    • Author(s)
      Maeda H, Ishikawa T, Michiue T.
    • Journal Title

      Legal Medicine

      Volume: 16 Issue: 2 Pages: 61-69

    • DOI

      10.1016/j.legalmed.2014.01.002

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Immunohistochemistry of connexin43 and zonula occludens-1 in the myocardium as markers of early ischemia in autopsy material2014

    • Author(s)
      Kawamoto O, Michiue T, Ishikawa T, Maeda H
    • Journal Title

      Histology and Histopathology

      Volume: 未定

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Molecular pathology of brain edema after severe burns in forensic autopsy cases with special regard to the importance of reference gene selection2013

    • Author(s)
      Wang Q, Ishikawa T, Michiue T, Zhu BL, Guan DW, Maeda H
    • Journal Title

      Int J Legal Med

      Volume: 127 Issue: 5 Pages: 887-889

    • DOI

      10.1007/s00414-013-0868-x

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Molecular pathology of pulmonary edema in forensic autopsy cases with special regard to fatal hyperthermia and hypothermia.2013

    • Author(s)
      Wang Q, Ishikawa T, Michiue T, Zhu BL, Guan DW, Maeda H.
    • Journal Title

      Forensic Sci Int.

      Volume: 228 Issue: 1-3 Pages: 137-141

    • DOI

      10.1016/j.forsciint.2013.03.007

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Postmortem catecholamine levels in pericardial and cerebrospinal fluids with regard to the cause of death in medicolegal autopsy.2013

    • Author(s)
      Ishikawa T, Quan L, Michiue T, Kawamoto O, Wang Q, Chen JH, Zhu BL, Maeda H.
    • Journal Title

      Leg med (Tokyo).

      Volume: 228 Issue: 1-3 Pages: 52-60

    • DOI

      10.1016/j.forsciint.2013.02.008

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comprehensive evaluation of pericardial biochemical markers in death investigation.2013

    • Author(s)
      Kawamoto O, Michiue T, Ishikawa T, Maeda H.
    • Journal Title

      Forensic Sci Int.

      Volume: 224 Issue: 1-3 Pages: 73-79

    • DOI

      10.1016/j.forsciint.2012.10.036

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 大阪市南部の司法解剖例における最近10年間の覚せい剤関連死亡例の解析.2015

    • Author(s)
      谷 直人,陳 建華,道上知美,織谷茂樹,石川隆紀
    • Organizer
      第62回日本法医学会学術近畿地方集会
    • Place of Presentation
      京都教育文化センター(京都府京都市)
    • Year and Date
      2015-11-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] 急性トラベルミン中毒による横紋筋融解症を呈した1剖検例.2015

    • Author(s)
      織谷茂樹,道上知美,陳 建華,谷 直人,石川隆紀
    • Organizer
      第62回日本法医学会学術近畿地方集会
    • Place of Presentation
      京都教育文化センター(京都府京都市)
    • Year and Date
      2015-11-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] 開胸食道内異物摘出術による奇静脈結紮・切断後の大量出血の一例.2015

    • Author(s)
      道上知美,陳 建華,谷 直人,石川隆紀.
    • Organizer
      第22回法医病理夏季セミナー
    • Place of Presentation
      岩手医科大学循環器医療センター(岩手県盛岡市)
    • Year and Date
      2015-09-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] 死後CTデータを用いた脳・脳脊髄液の容積分析.2015

    • Author(s)
      道上知美,石川隆紀,前田 均.
    • Organizer
      第99次日本法医学会学術全国集会
    • Place of Presentation
      高知市文化プラザかるぽーと(高知県高知市)
    • Year and Date
      2015-06-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] 死後CTデータを用いた体幹部脊柱の体積分析による身長推定:予備的検討.2015

    • Author(s)
      道上知美,石川隆紀,佐古田茂樹,織谷茂樹,前田 均
    • Organizer
      第99次日本法医学会学術全国集会
    • Place of Presentation
      高知市文化プラザかるぽーと(高知県高知市)
    • Year and Date
      2015-06-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] 死後CTデータを用いた心膜血腫例の心・循環・呼吸機能分析.2015

    • Author(s)
      道上知美,石川隆紀,前田 均.
    • Organizer
      第99次日本法医学会学術全国集会
    • Place of Presentation
      高知市文化プラザかるぽーと(高知県高知市)
    • Year and Date
      2015-06-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] RT-PCRによる剖検例の肝臓内mRNA定量法の2施設共同精度検定.2015

    • Author(s)
      陳 建華,木村章彦,道上知美,石川隆紀,近藤稔和,前田 均
    • Organizer
      第99次日本法医学会学術全国集会
    • Place of Presentation
      高知市文化プラザかるぽーと(高知県高知市)
    • Year and Date
      2015-06-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] 水中死体の体位と体格・体型.2015

    • Author(s)
      陳 建華,道上知美,石川隆紀,前田 均
    • Organizer
      第99次日本法医学会学術全国集会
    • Place of Presentation
      高知市文化プラザかるぽーと(高知県高知市)
    • Year and Date
      2015-06-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] 法医剖検例における膵臓被膜下および間質内出血の意義と膵臓関連ホルモンの動態について-予備的検討-.2015

    • Author(s)
      石川隆紀,遠藤 稔,湯浅 勲
    • Organizer
      第99次日本法医学会学術全国集会
    • Place of Presentation
      高知市文化プラザかるぽーと(高知県高知市)
    • Year and Date
      2015-06-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] ADAMT13遺伝子のp.P475S多型の地理的分布.2015

    • Author(s)
      湯浅 勲,石川隆紀,松末 綾,中屋敷徳,西向弘明
    • Organizer
      第99次日本法医学会学術全国集会
    • Place of Presentation
      高知市文化プラザかるぽーと(高知県高知市)
    • Year and Date
      2015-06-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] 法医生化学・分子病理学-Ⅱ.2015

    • Author(s)
      石川隆紀
    • Organizer
      公開ワークショップ「法医鑑定・死因究明のための新しい概念と技術-死から命を学ぶ-」
    • Place of Presentation
      あべのハルカス会議室(大阪府大阪市)
    • Year and Date
      2015-05-02
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 将来展望と今後の課題.2015

    • Author(s)
      石川隆紀
    • Organizer
      公開ワークショップ「法医鑑定・死因究明のための新しい概念と技術-死から命を学ぶ-」
    • Place of Presentation
      あべのハルカス会議室(大阪府大阪市)
    • Year and Date
      2015-05-02
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Myocardial immunohistochemistry of fatal arrhythmia and exited delirium.2014

    • Author(s)
      Kawamoto O, Michiue T, Ishikawa T, Maeda H.
    • Organizer
      9th International Symposium on Advances in Legal Medicine.
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2014-06-16 – 2014-06-20
    • Related Report
      2014 Research-status Report
  • [Presentation] Posomortem serum and urinary cortisol levels as a stress marker with regard to the cause of death.2014

    • Author(s)
      2.Michiue T, Kawamoto O, Chen JH, Ishikawa T, Maeda H.
    • Organizer
      9th International Symposium on Advances in Legal Medicine.
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2014-06-16 – 2014-06-20
    • Related Report
      2014 Research-status Report
  • [Presentation] Evaluation of postmortem drug levels in the cerebrospinal fluid.2014

    • Author(s)
      4.Tominaga M, Michiue T, Kawamoto O, Hishmat AM, Oritani S, Ishikawa T, Maeda H
    • Organizer
      9th International Symposium on Advances in Legal Medicine.
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2014-06-16 – 2014-06-20
    • Related Report
      2014 Research-status Report
  • [Presentation] Cardiac biomarkers in blood, and pericardial and cerebrospinal fluids of forensic autopsy cases: A reassessment with special regard to postmortem interval.2014

    • Author(s)
      Chen JH, Kawamoto O, Michiue T, Ishikawa T, Maeda H.
    • Organizer
      9th International Symposium on Advances in Legal Medicine.
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2014-06-16 – 2014-06-20
    • Related Report
      2014 Research-status Report
  • [Presentation] Electrolyte contents of pleural effusions in forensic autopsy cases.2014

    • Author(s)
      Michiue T, Kawamoto O, Chen JH, Ishikawa T, Maeda H.
    • Organizer
      9th International Symposium on Advances in Legal Medicine.
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2014-06-16 – 2014-06-20
    • Related Report
      2014 Research-status Report
  • [Presentation] Postmortem biochemistry of vitreous humor with regard to the cause of death.2014

    • Author(s)
      Michiue T, Kawamoto O, Chen JH, Ishikawa T, Maeda H.
    • Organizer
      9th International Symposium on Advances in Legal Medicine.
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2014-06-16 – 2014-06-20
    • Related Report
      2014 Research-status Report
  • [Presentation] Immunohistochemical marker for Na+ CP Type N alpha and R1193 Q polymorphism in the SCN5A gene in a case of sudden cardiac death.2014

    • Author(s)
      Ishikawa T, Yuasa I, Endo M.
    • Organizer
      9th International Symposium on Advances in Legal Medicine.
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2014-06-16 – 2014-06-20
    • Related Report
      2014 Research-status Report
  • [Presentation] Histopathology of the thyroid gland in mechanical asphyxia2013

    • Author(s)
      Ishikawa T, Michiue T, Kawamoto O, Seo T, Matsushita S, Maeda H.
    • Organizer
      92. Jahrestagung der Deutschen Gesellschaft fur Rechtsmedizin,
    • Place of Presentation
      Universitat des Saarlandes, Homburg, Germany
    • Related Report
      2013 Research-status Report
  • [Presentation] RT-PCRによる剖検例の心筋内mRNA定量における低酸素・虚血の影響:ハウスキーピング遺伝子4種を用いた検討.2013

    • Author(s)
      陳 建華, 道上 知美, 石川 隆紀, 王 起, 河元 理, 前田 均.
    • Organizer
      第97次日本法医学会学術全国集会
    • Place of Presentation
      ロイトン札幌, 札幌,北海道
    • Related Report
      2013 Research-status Report
  • [Presentation] 法医解剖例における心筋マーカーの診断学的意義の再評価.2013

    • Author(s)
      陳 建華, 道上 知美, 河元 理, 冨永 麻里子, 石川 隆紀, 前田 均.
    • Organizer
      第60回日本法医学会学術近畿地方集会
    • Place of Presentation
      近畿大学病院, 狭山,大阪
    • Related Report
      2013 Research-status Report
  • [Book] History and current status of forensic science in Japan. In: Douglas H. Ubelaker, editor. The Global Practice of Forensic Science, 1st ed.2015

    • Author(s)
      Maeda H, Ishikawa T, and Kondo T
    • Total Pages
      15
    • Publisher
      New York :John Willey & Sons, Ltd.
    • Related Report
      2015 Annual Research Report
  • [Book] Postmortem Changes: Postmortem Electrolyte Disturbances. In: Payne-James J. and Byard R.W., editors.2015

    • Author(s)
      Maeda H, Michiue T, and Ishikawa T.
    • Total Pages
      10
    • Publisher
      Encyclopedia of Forensic and Legal Medicine, 2nd ed., vol 4.
    • Related Report
      2015 Annual Research Report
  • [Book] Encyclopedia of Forensic Sciences, System Response to Trauma2013

    • Author(s)
      Ishikawa T, Maeda H
    • Publisher
      Elsevier
    • Related Report
      2013 Research-status Report
  • [Book] Encyclopedia of Forensic Sciences, Hyperthermia and Hypothermia2013

    • Author(s)
      Ishikawa T, Maeda H
    • Publisher
      Elsevier
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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