Two approaches for identification of SNPs associated with ridge counts of human finger prints.

• Project/Area Number: 25460881
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Legal medicine
• Research Institution: Kurume University
• Principal Investigator: Soejima Mikiko 久留米大学, 医学部, 講師 (80279140)
• Co-Investigator(Kenkyū-buntansha): KODA Yoshiro 久留米大学, 医学部, 教授 (90231307)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 指紋 / 隆線数 / 多因子遺伝 / SNPｓ / 関連解析 / 遺伝子多型 / ゲノムワイド多型解析

Outline of Final Research Achievements

Fingerprint is still powerful tool of personal identification. To understand the genetic background of the determination of the total ridge counts that is supposed to be a multifactorial genetic trait, we explored two approaches. Although we examined the SNPs that are highly placed on genome-wide SNPs lists in association with the total ridge counts by using “large” and “small” number groups on the samples with middle number groups, we could not get any SNPs with statistically significant.In addition, the analysis of SNPs of the causal genes of the diseases that represents fingerprint abnormality revealed no candidate polymorphisms.

Research Products

• [Journal Article] Corneodesmosin gene deletion is prevalent in Japanese patients with peeling skin disease: identification of 2 new cases. (2016)
  • Author(s): Teye K, Suga Y, Numata S, Ishii N, Krol RP, Ohata C, Matsuda M, Honma M, Ishida-Yamamoto A, Hamada T, Hashimoto T.
  • Journal Title: Journal of Dermatological Science Volume: 82 Issue: 2 Pages: 134-137
  • DOI: 10.1016/j.jdermsci.2016.01.012
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Haptoglobin promoter polymorphism rs5472 as a prognostic biomarker for peptide vaccine efficacy in castration-resistant prostate cancer patients. (2015)
  • Author(s): Araki H, Pang X, Komatsu N, Soejima M, Miyata N, Takaki M, Muta S, Sasada T, Noguchi M, Koda Y, Itoh K, Kuhara S, Tashiro K.
  • Journal Title: Cancer Immunol Immunother. Volume: 64 Issue: 12 Pages: 1565-1573
  • DOI: 10.1007/s00262-015-1756-7
  • Peer Reviewed
• [Journal Article] Haptoglobin genotyping of Vietnamese: global distribution of HPdel, complete deletion allele of the HP gene. (2015)
  • Author(s): Soejima M, Agusa T, Iwata H, Fujihara J, Kunito T, Takeshita H, Lan VT, Minh TB, Takahashi S, Trang PT, Viet PH, Tanabe S, Koda Y.
  • Journal Title: Legal Medicine Volume: 17 Issue: 1 Pages: 14-16
  • DOI: 10.1016/j.legalmed.2014.08.004
  • Peer Reviewed
• [Journal Article] An autopsy case of subarachnoid hemorrhage due to ruptured cerebral aneurysm associated with polycystic kidney disease caused by a novel PKD1 mutation. (2014)
  • Author(s): Soejima M, Sugita Y, Koda Y.
  • Journal Title: Forensic Sci Int. Volume: 242 Pages: e18-e21
  • DOI: 10.1016/j.forsciint.2014.06.029
  • Peer Reviewed
• [Journal Article] Genetic factors associated with serum haptoglobin level in a Japanese population. (2014)
  • Author(s): Soejima M, Sagata N, Komatsu N, Sasada T, Kawaguchi A, Itoh K, Koda Y.
  • Journal Title: Clin Chim Acta. Volume: 433 Pages: 54-57
  • DOI: 10.1016/j.cca.2014.02.029
  • Peer Reviewed
• [Journal Article] Evaluation of point-of-care testing of C-reactive protein in forensic autopsy cases. (2014)
  • Author(s): Soejima M, Koda Y.
  • Journal Title: Forensic Sci Int. Volume: 237 Pages: 27-29
  • DOI: 10.1016/j.forsciint.2014.01.008
  • Peer Reviewed
• [Presentation] 法医試料におけるケトン体測定の前処理法と簡易測定器の検討 (2015)
  • Author(s): 副島 美貴子, 神田 芳郎
  • Organizer: 第65回日本法医学会学術九州地方集会
  • Place of Presentation: MRT micc エメラルドホール（宮崎県宮崎市）
  • Year and Date: 2015-10-16
• [Presentation] 血清ハプトグロビン濃度に関与する遺伝子多型に働く自然選択の可能性 (2015)
  • Author(s): 副島 美貴子, 神田 芳郎
  • Organizer: 第99次日本法医学会学術全国集会
  • Place of Presentation: 高知市文化プラザ かるぽーと(高知県高知市）
  • Year and Date: 2015-06-10
• [Presentation] ベトナム人のハプトグロビン（HP）多型解析とHP欠失アリルHPdelの地理的分布. (2014)
  • Author(s): 副島美貴子, 神田芳郎
  • Organizer: 日本DNA多型学会第23回学術集会
  • Place of Presentation: 愛知県産業労働センターウインクあいち（愛知県名古屋市）
  • Year and Date: 2014-11-27
• [Presentation] モンゴル人の血中ハプトグロビン濃度に影響する遺伝因子について. (2014)
  • Author(s): 副島美貴子, 神田芳郎
  • Organizer: 第64回日本法医学会学術九州地方集会
  • Place of Presentation: 鹿児島県市町村自治会館（鹿児島県鹿児島市）
  • Year and Date: 2014-10-10
• [Presentation] An autopsy case of subarachnoid hemorrhage due to ruptured cerebral aneurysm associated with polycystic kidney disease caused by a novel PKD1 mutation. (2014)
  • Author(s): Soejima M, Sugita Y, Koda Y.
  • Organizer: 9th International Symposium on Advances in Legal Medicine (ISALM)-the 98th Congress of the Japanese Society of Legal Medicine.
  • Place of Presentation: 福岡国際会議場(福岡県福岡市）
  • Year and Date: 2014-06-18
• [Presentation] 日本人集団におけるハプトグロビン(HP)遺伝子多型と血清HP濃度の関連 (2013)
  • Author(s): 副島美貴子、神田芳郎
  • Organizer: 第97次日本法医学会総会
  • Place of Presentation: ロイトン札幌（北海道札幌市）
• [Presentation] 血清ハプトグロビン(HP)濃度に影響する遺伝子多型が形成するハプロタイプの集団間差 (2013)
  • Author(s): 副島美貴子、神田芳郎
  • Organizer: 日本DNA多型学会第22回学術集会
  • Place of Presentation: 仙台市戦災復興記念館（宮城県仙台市）
• [Presentation] 簡易C反応性蛋白検査キットの有用性の検討 (2013)
  • Author(s): 副島美貴子、神田芳郎
  • Organizer: 第63回日本法医学会学術九州地方集会
  • Place of Presentation: 九州大学 コラボステーションI（福岡県福岡市）
• [Book] DNA多型（日本DNA多型学会編） (2013)
  • Author(s): 神田芳郎,副島美貴子: FUT2融合遺伝子（sefus）スクリーニング法による新規ハイブリッドアリルの同定
  • Total Pages: 305
  • Publisher: 東洋書店
• [Remarks] 久留米大学医学部法医学・人類遺伝学講座
  • URL: http://www.med.kurume-u.ac.jp/med/foren/
• [Remarks] 久留米大学医学部法医学・人類遺伝学講座
  • URL: http://www.med.kurume-u.ac.jp/med/foren/