Multidemensional analysis of abulia in patients with dementia

• Project/Area Number: 25460885
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: Yamagata University
• Principal Investigator: Saito Naohiro 山形大学, 医学(系)研究科(研究院), 講師 (20534168)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 認知症 / 無為 / 意欲低下 / 失感情症 / 抑うつ / BPSD / 精神症状 / 行動障害

Outline of Final Research Achievements

It's well known that behavioral and psychological symptoms of dementia (BPSD) causes low quality of life in patients and caregivers. Abulia is a state of reduction in speech, movement, thought and emotional reaction. It is most commonly observed in patients with dementia. However, it has not been established how to evaluate and approach for treating it. We investigated depression, apathy, anhedonia and alexithymia in patients with dementia.

Research Products

• [Journal Article] Surprise signals in the supplementary eye field: fectified prediction errors drive exploration-exploitation transitions. (2015)
  • Author(s): Kawaguchi N, Sakamoto K, Saito N, Furusawa Y, Tanji J, Aoki M, Mushiake H
  • Journal Title: J Neurophysiol Volume: 113 Issue: 3 Pages: 1001-1014
  • DOI: 10.1152/jn.00128.2014
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 臨床的認知症尺度（CDR）の判断と問題解決能力の項目評価に関する検討. (2015)
  • Author(s): 伊藤さゆり、斎藤尚宏、遠藤明日香、市毛福子、小島ひとみ、遠藤京子、飛田宗重、鈴木匡子
  • Organizer: 第26回山形認知症研究会
  • Place of Presentation: 山形県山形市山形国際ホテル
  • Year and Date: 2015-04-04
• [Presentation] 非流暢な発話を呈した伝導失語例 (2014)
  • Author(s): 大石如香，丹治和世，斎藤尚宏，鈴木匡子
  • Organizer: 第38回日本高次脳機能障害学会学術総会
  • Place of Presentation: 仙台国際センター（宮城）
  • Year and Date: 2014-11-28 – 2014-11-29
• [Presentation] アルツハイマー病と考えられた喚語困難を主体とする原発性進行性失語の一例 (2014)
  • Author(s): 斎藤尚宏，伊藤さゆり，飛田宗重，鈴木匡子
  • Organizer: 第19回日本神経精神医学会
  • Place of Presentation: つくば国際会議場（茨城）
  • Year and Date: 2014-10-01
• [Presentation] 病巣部位のとらえ方 (2014)
  • Author(s): 斎藤尚宏
  • Organizer: 第38回日本神経心理学学会学術集会
  • Place of Presentation: 山形テルサ（山形）
  • Year and Date: 2014-09-26 – 2014-09-27
• [Presentation] アルツハイマー病における質感認知障害－野菜鮮度判断検査を用いた検討－ (2014)
  • Author(s): 宇野友貴，伊藤さゆり，斎藤尚宏，丹治和世，鈴木匡子
  • Organizer: 第38回日本神経心理学学会学術集会
  • Place of Presentation: 山形テルサ（山形）
  • Year and Date: 2014-09-26 – 2014-09-27
• [Presentation] The Japanese version of the Montreal cognitive assessment performance in patients with Parkinson's disease (2013)
  • Author(s): Naohiro Saito, Yuko Hayakawa, Haruko Tanji, Manabu Wada, Toru Kawanami, Takeo Kato and Kyoko Suzuki
  • Organizer: International Psychogeriatric Association, 16th International Congress
  • Place of Presentation: Coex, Seoul, Republic of Korea
• [Book] Advances in Cognitive Neurodynamics (IV) (2015)
  • Author(s): K Sakamoto, N Saito, S Yoshida, H Mushiake
  • Total Pages: 618
  • Publisher: Springer