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The regulation of bone metabolism by digestive tract: A study on the mechanism of incretin-induced bone formation

Research Project

Project/Area Number 25460899
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General internal medicine(including psychosomatic medicine)
Research InstitutionShimane University

Principal Investigator

Sugimoto Toshitsugu  島根大学, 医学部, 教授 (00226458)

Co-Investigator(Kenkyū-buntansha) KANAZAWA Ippei  島根大学, 医学部, 助教 (50452553)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsインクレチン / DPP-4 / 骨代謝 / GLP-1 / GIP / 骨芽細胞 / 骨形成 / 骨折
Outline of Final Research Achievements

We demonstrated that incretin, such as gastric inhibitory polypeptide and glucagon-like peptide-1, had no effects on the differentiation and mineralization of mesenchymal stem cell-like ST2 cells and osteoblastic MC3T3-E1 cells as well as the expression of RANKL in osteocytic MLO-Y4 cells. Moreover, bone volume and bone strength were not different between C57BL mice with and without administration of a dipeptidyl peptidase-4 (DPP-4) inhibitor. In a clinical study, elevated serum DPP-4 levels were significantly and positively associated with the presence of metabolic syndrome in men with type 2 diabetes. In addition, increased serum DPP-4 levels were significantly associated with the risk of multiple vertebral fractures through bone resorption in the population.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (7 results)

All 2016 2015 2014

All Journal Article (3 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results,  Acknowledgement Compliant: 2 results,  Open Access: 1 results) Presentation (4 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Serum dipeptidyl peptidase-4 is associated with multiple vertebral fractures in type 2 diabetes mellitus2016

    • Author(s)
      Masakazu Notsu, Ippei Kanazawa, Sayuri Tanaka, Toshitsugu Sugimoto
    • Journal Title

      Clinical Endocrinology

      Volume: 84 Issue: 3 Pages: 332-337

    • DOI

      10.1111/cen.12971

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Visceral fat obesity increases serum DPP-4 levels in men with type 2 diabetes mellitus2016

    • Author(s)
      Sayuri Tanaka, Ippei Kanazawa, Masakazu Notsu, Toshitsugu Sugimoto
    • Journal Title

      Diabetes Research and Clinical Practice

      Volume: 未定

    • NAID

      120006334822

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 2型糖尿病男性において血中DPP-4濃度高値は多発椎体骨折の危険因子である2015

    • Author(s)
      野津雅和、金沢一平、田中小百合、杉本利嗣
    • Journal Title

      Osteoporosis Japan

      Volume: 23 Pages: 46-50

    • NAID

      120006870500

    • Related Report
      2014 Research-status Report
    • Open Access
  • [Presentation] Visceral fat obesity and metabolic syndrome increase serum DPP-4 levels in type 2 diabetes mellitus2015

    • Author(s)
      Sayuri Tanaka, Ippei Kanazawa, Masakazu Notsu, Toshitsugu Sugimoto
    • Organizer
      51th Annual Meeting of the European Association for the Study of Diabetes
    • Place of Presentation
      Sweden, Stockholm
    • Year and Date
      2015-09-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 血中DPP-4濃度高値は多発椎体骨折リスクと関連する2015

    • Author(s)
      野津雅和、金沢一平、田中小百合、杉本利嗣
    • Organizer
      第58回日本糖尿病学会年次学術集会
    • Place of Presentation
      山口県下関市海峡メッセ下関
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] 2型糖尿病における血清DPP-4濃度とCT診断による内臓脂肪型肥満との関連性の検討2015

    • Author(s)
      田中小百合、金沢一平、野津雅和、杉本利嗣
    • Organizer
      第58回日本糖尿病学会年次学術集会
    • Place of Presentation
      山口県下関市海峡メッセ下関
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] 2型糖尿病男性において血中DPP-4濃度高値は多発椎体骨折の危険因子である2014

    • Author(s)
      野津雅和、金沢一平、田中小百合、杉本利嗣
    • Organizer
      第16回日本骨粗鬆症学会
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2014-10-23 – 2014-10-25
    • Related Report
      2014 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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