The investigation on the mechanisms of bone metabolic disorders caused by oxidative stress or Wnt/beta-catenin signaling pathway under type 2 diabetic condition
| Project/Area Number |
25460900
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | Shimane University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KIYOHARA NOBUAKI 島根大学, 医学部, 助教 (50733656)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 酸化ストレス / 骨質 / 骨脆弱性 / ２型糖尿病 / ホモシステイン / 8-OHdG / スクレロスチン / Wnt/β-catenin経路 |
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| Outline of Final Research Achievements |
We have reported that patients with type 2 diabetes mellitus have an increased bone fragility caused by poor bone quality because the elevated risk of fractures is observed despite their higher bone mineral density compared with non-diabetic subjects. However, any factors associated with poor bone quality remains unclear. Elevated levels of homocysteine and 8-OHdG, which are surrogate markers reflecting induction and tissue damages of oxidative stress, were significantly and positively associated with the presence of vertebral fractures independent of bone mineral density. These findings suggested that elevated oxidative stress was involved in aggravation of bone quality.
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Report
(4 results)
Research Products
(102 results)
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[Presentation] Intensive glycemic control improved the excretion of urine mineral ions in type 2 diabetes mellitus2013
Author(s)
Tada Y, Yamaguchi T, Tanaka K, Tanaka S, Notsu M, Miyake H, Morita M, Ogawa N, Kanazawa I, Yamamoto M, Sugimoto T
Organizer
The 34th International Diabetes Federation World Diabetes Congress 2013
Place of Presentation
Melbourne, Austraria
Related Report
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