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Neural mechanism underlying stress vulnerability: the long-lasting effects of pubertal stress experiences on stress responses in adulthood

Research Project

Project/Area Number 25460901
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General internal medicine(including psychosomatic medicine)
Research InstitutionAichi Medical University (2014-2015)
Kochi University (2013)

Principal Investigator

YAMAGUCHI Naoko  愛知医科大学, 医学部, 講師 (50380324)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsストレス / コルチコステロン / セロトニン / 思春期 / エストロゲン
Outline of Final Research Achievements

The HPA axis in neonatal animals shows lower reactivity, and then matures during puberty. It has been known that adverse experiences in early life including puberty cause long-lasting behavioral and psychological effects, resulting in changes in emotional function and the stress response in adulthood. However, little is known about the neural mechanisms underlying such long-lasting effects.
In this study, to elucidate the effects of repeated restraint stress during puberty on stress responses in the brain of adult rats, we examined the expression levels of several stress-related factors such as tryptophan hydroxylase (TPH; a marker of serotonergic neurons), oxytocin and corticotropin-releasing factors using pubertal male rats. Our results showed that pubertal stress experience affects stress-induced expression of TPH in the dorsal raphe nucleus in adulthood. These suggest that changes in serotonergic system caused by pubertal stress experience may be related to long-lasting effects.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (10 results)

All 2016 2015 2014

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 3 results,  Acknowledgement Compliant: 3 results) Presentation (6 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Effects of aging on stress-related responses of serotonergic neurons in the dorsal raphe nucleus of male rats2016

    • Author(s)
      Yamaguchi N, Nakajima N, Okada S, Yuri K
    • Journal Title

      Neurobiology of Stress

      Volume: 3 Pages: 43-51

    • DOI

      10.1016/j.ynstr.2016.01.002

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Centrally administered isoproterenol induces sympathetic outflow via brain prostaglandin E2-mediated mechanisms in rats.2015

    • Author(s)
      Ando K, Kondo F, Yamaguchi N, Tachi M, Fukayama M, Yoshikawa K, Gosho M, Fujiwara Y, Okada S.
    • Journal Title

      Auton Neurosci.

      Volume: 189 Pages: 1-7

    • DOI

      10.1016/j.autneu.2014.12.002

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Modification of female and male social behaviors in estrogen receptor beta knockout mice by neonatal maternal separation.2014

    • Author(s)
      Tsuda MC, Yamaguchi N, Nakata M, Ogawa S
    • Journal Title

      Frontiers in Neuroscience,

      Volume: 8 Pages: 274-274

    • DOI

      10.3389/fnins.2014.00274

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Estrogen-dependent changes in estrogen receptor-β mRNA expression in middle-aged female rat brain.2014

    • Author(s)
      Yamaguchi N, Yuri K.
    • Journal Title

      Brain Research

      Volume: 1543 Pages: 49-57

    • DOI

      10.1016/j.brainres.2013.11.010

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Site-specific action of testosterone via estrogen receptor β, not α, in the medial preoptic area is required for the full expression of aggressive behavior in male mice2015

    • Author(s)
      Yamaguchi N, Sano K, Nakata M, Musatov S, Sakamoto T, Ogawa S
    • Organizer
      45th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      McCormick Place(イリノイ州・シカゴ)
    • Year and Date
      2015-10-21
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ストレスによる視床下部室傍核オキシトシンニューロンの発現変化に及ぼす加齢の影響と性差2015

    • Author(s)
      山口奈緒子, 岡田尚志郎
    • Organizer
      第42回日本神経内分泌学会・第23回日本行動神経内分泌研究会合同学術集会
    • Place of Presentation
      仙台市戦災復興記念館(宮城県・仙台市)
    • Year and Date
      2015-09-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Role of estrogen receptor β in the medial preoptic area in the regulation of aggressive behavior in male mice2015

    • Author(s)
      Nakata M, Sano K, Musatov S, Yamaguchi N, Sakamoto T, Ogawa S
    • Organizer
      第120回日本解剖学会総会・全国学術集会・第92回日本生理学会大会合同大会
    • Place of Presentation
      神戸国際会議場(兵庫県・神戸市)
    • Year and Date
      2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] Effects of aging on stress-related changes in the expression of serotonergic neurons in the rat dorsal raphe2015

    • Author(s)
      Yamaguchi N, Okada S, Yuri Y
    • Organizer
      第88回日本薬理学会年会
    • Place of Presentation
      名古屋国際会議場(愛知県・名古屋市)
    • Year and Date
      2015-03-20
    • Related Report
      2014 Research-status Report
  • [Presentation] Effects of site-specific knockdown of estrogen receptor beta in the dorsal raphe nucleus on female sexual behavior in mice2014

    • Author(s)
      Ogawa S, Morimoto C, Sano K, Nakata M, Musatov S, Yamaguchi N, Sakamoto T
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2014-09-13
    • Related Report
      2014 Research-status Report
  • [Presentation] Effect of aging on estrogen-dependent changes in estrogen receptor-β mRNA expression in female rat brain2014

    • Author(s)
      Yamaguchi N, Yuri K
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2014-09-12
    • Related Report
      2014 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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