| Project/Area Number |
25460911
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
General internal medicine(including psychosomatic medicine)
|
|---|
| Research Institution | Kitasato University |
|---|
Principal Investigator |
Oikawa Teturo 北里大学, 東洋医学総合研究所, 研究員 (10370165)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
HORI Masatoshi 東京大学, 大学院農学生命科学研究科獣医薬理学教室, 准教授 (70211547)
ENDO Mari 北里大学, 東洋医学総合研究所, 研究員 (60296829)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
|---|
| Keywords | 抗炎症作用 / POI / 乾姜 / マクロファージ / 大建中湯 / 東洋医学 / 術後腸管麻痺 / ニコチン性アセチルコリン受容体 |
|---|
| Outline of Final Research Achievements |
We previously reported that Daikenchuto (DKT), a gastrointestinal prokinetic Japanese herbal medicine, serves as a novel therapeutic agent for postoperative ileus (POI) characterized by its anti-inflammatory potency,which may be partly mediated by activation of α7 nicotinic acetylcholine receptor (nAChR). In this study, we attempted to identify the target herb(s) in DKT to induce anti-inflammatory ability.The macrophage infiltration-suppressing action as part of the anti-inflammatory activity of DKT in POI is dependent on the inclusion of zingiberis processum rhizome. Zingiberis processum rhizome may be a main component which induces anti-inflammatory activity for POI.
|
