Zingiberis Siccatum Rhizoma, active component in Kampo formula Daikenchuto ameliorates postoperative ileus through inhibition of macrophage infiltration
| Project/Area Number |
25460911
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | Kitasato University |
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Principal Investigator |
Oikawa Teturo 北里大学, 東洋医学総合研究所, 研究員 (10370165)
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| Co-Investigator(Renkei-kenkyūsha) |
HORI Masatoshi 東京大学, 大学院農学生命科学研究科獣医薬理学教室, 准教授 (70211547)
ENDO Mari 北里大学, 東洋医学総合研究所, 研究員 (60296829)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 抗炎症作用 / POI / 乾姜 / マクロファージ / 大建中湯 / 東洋医学 / 術後腸管麻痺 / ニコチン性アセチルコリン受容体 |
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| Outline of Final Research Achievements |
We previously reported that Daikenchuto (DKT), a gastrointestinal prokinetic Japanese herbal medicine, serves as a novel therapeutic agent for postoperative ileus (POI) characterized by its anti-inflammatory potency,which may be partly mediated by activation of α7 nicotinic acetylcholine receptor (nAChR). In this study, we attempted to identify the target herb(s) in DKT to induce anti-inflammatory ability.The macrophage infiltration-suppressing action as part of the anti-inflammatory activity of DKT in POI is dependent on the inclusion of zingiberis processum rhizome. Zingiberis processum rhizome may be a main component which induces anti-inflammatory activity for POI.
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Report
(4 results)
Research Products
(6 results)
