Relationship between white matter changes and cognitive/functional impairment :an association of amino acid transporter.

• Project/Area Number: 25460912
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: Kyorin University
• Principal Investigator: KOZAKI KOICHI 杏林大学, 医学部, 教授 (80272540)
• Co-Investigator(Renkei-kenkyūsha): NAGAI KUMIKO 杏林大学, 医学部, 実験助手 (60398592)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 大脳皮質下病変 / 慢性脳低還流 / 大脳白質病変 / マウス / 学習記憶試験

Outline of Final Research Achievements

In a mouse model of chronic cerebral hypoperfusion, inflammation markers were raised and astrocyte (GFAP) and microglia (iba1) increased significantly. As a behavioral change after chronic cerebral hypoperfusion, a decline of novel preference and a decline of curiosity were observed in young mouse and adult mouse over 60weeks old.
There was a difference of behavioral change after hypoperfusion between male and female mouse.