Iron is associated with the development of hypertension

• Project/Area Number: 25460919
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: Hyogo Medical University
• Principal Investigator: Naito Yoshiro 兵庫医科大学, 医学部, 講師 (10446049)
• Co-Investigator(Kenkyū-buntansha): MASUYAMA Tohru 兵庫医科大学, 医学部, 教授 (70273670)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 高血圧 / 鉄 / 慢性腎臓病 / 肺高血圧症 / 内科学 / 高血圧症

Outline of Final Research Achievements

Iron is an essential element for life, while excessive iron contributes to increase the oxidative stress. We investigate the impacts of dietary iron restriction on the development of hypertension in experimental and clinical studies. Dietary iron restriction attenuated the development of hypertension in experimental hypertensive animals. The cellular iron import protein transferrin receptor 1 was increased in hypertensive damaged tissues (i.e. aorta, kidney). Although 3 months of dietary iron restriction did not significantly decrease blood pressure, iron restriction decreased cardio ankle vascular index in patients with essential hypertension.

Research Products

• [Journal Article] Experience of dietary iron intake restriction in patients with essential hypertension (2016)
  • Author(s): Oboshi M, Naito Y, Sawada H, Ando T, Iwasaku T, Eguchi A, Okuhara Y, Nishimura K, Soyama Y, Fujii K, Hirotani S, Mano T, Ishihara M, Masuyama T.
  • Journal Title: International Journal of Cardiology Volume: 206 Pages: 154-156
  • DOI: 10.1016/j.ijcard.2016.01.053
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Association of dietary iron restriction with left ventricular remodeling after myocardial infarction in mice (2016)
  • Author(s): Eguchi A, Naito Y, Iwasaku T, Okuhara Y, Morisawa D, Sawada H, Nishimura K, Oboshi M, Fujii K, Mano T, Masuyama T, Hirotani S.
  • Journal Title: Heart and Vessels Volume: 31 Issue: 2 Pages: 222-229
  • DOI: 10.1007/s00380-014-0621-5
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Transferrin receptor 1 in chronic hypoxia-induced pulmonary vascular remodeling (2015)
  • Author(s): Naito Y, Hosokawa M, Sawada H, Oboshi M, Hirotani S, Iwasaku T, Okuhara Y, Morisawa D, Eguchi A, Nishimura K, Soyama Y, Fujii K, Mano T, Ishihara M, Tsujino T, Masuyama T.
  • Journal Title: American Journal of Hypertension Volume: 印刷中 Issue: 6 Pages: 713-718
  • DOI: 10.1093/ajh/hpv163
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Aortic iron overload with oxidative stress and inflammation in human and murine abdominal aortic aneurysm. (2015)
  • Author(s): Hao H, Sawada T, Naito Y, Oboshi M, Hirotani S, Mitsuno M, Miyamoto Y, Hirota S, Masuyama T
  • Journal Title: Arteriosclerosis Thrombosis and Vascular Biology Volume: 35 Issue: 6 Pages: 1507-1514
  • DOI: 10.1161/atvbaha.115.305586
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Temporary dietary iron restriction affects the process of thrombus resolution in a rat model of deep vein thrombosis (2015)
  • Author(s): Oboshi M, Naito Y, Sawada H, Hirotani S, Iwasaku T, Okuhara Y, Morisawa D, Eguchi A, Nishimura K, Fujii K, Mano T, Ishihara M, Masuyama T.
  • Journal Title: PLoS One Volume: 10 Issue: 5 Pages: e0126611-e0126611
  • DOI: 10.1371/journal.pone.0126611
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Cardiac remodeling in response to chronic iron deficiency: role of the erythropoietin receptor. (2015)
  • Author(s): Naito Y, Sawada H, Oboshi M, Iwasaku T, Okuhara Y, Morisawa D, Eguchi A, Hirotani S, Mano T, Tsujino T, Masuyama T.
  • Journal Title: Journal of Hypertension Volume: 33 Issue: 6 Pages: 1267-1275
  • DOI: 10.1097/hjh.0000000000000547
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Iron restriction inhibits renal injury in aldosterone/salt-induced hypertensive mice. (2015)
  • Author(s): Sawada H, Naito Y, Oboshi M, Iwasaku T, Okuhara Y, Morisawa D, Eguchi A, Hirotani S, Masuyama T.
  • Journal Title: Hypertension Research Volume: 38 Issue: 5 Pages: 317-322
  • DOI: 10.1038/hr.2015.13
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Impact of dietary iron restriction on the development of monocrotaline-induced pulmonary vascular remodeling and right ventricular failure in rats. (2013)
  • Author(s): Naito Y, Hosokawa M, Hao H, Sawada H, Hirotani S, Iwasaku T, Okuhara Y, Eguchi A, Hirota S, Ohyanagi M, Tsujino T, Masuyama T.
  • Journal Title: Biochem Biophys Res Commun. Volume: 436 Issue: 2 Pages: 145-51
  • DOI: 10.1016/j.bbrc.2013.05.059
  • Peer Reviewed
• [Journal Article] Increased renal iron accumulation in hypertensive nephropathy of salt-loaded hypertensive rats. (2013)
  • Author(s): Naito Y, Sawada H, Oboshi M, Fujii A, Hirotani S, Iwasaku T, Okuhara Y, Eguchi A, Morisawa D, Ohyanagi M, Tsujino T, Masuyama T.
  • Journal Title: PLoS One Volume: 8 Issue: 10 Pages: e75906-e75906
  • DOI: 10.1371/journal.pone.0075906
  • Peer Reviewed
• [Presentation] A Cellular Iron Transporter in the Development of Pulmonary Vascular Remodeling (2016)
  • Author(s): Naito Y, Sawada H, Oboshi M, Iwasaku T, Okuhara Y, Eguchi A, Nishimura K, Soyama Y, Hirotani S, Mano T, Ishihara M, Masuyama T.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台国際センター （宮城県、仙台市）
  • Year and Date: 2016-03-18
• [Presentation] Role of transferrin receptor 1 in pulmonary arterial hypertension (2015)
  • Author(s): Naito Y, Sawada H, Oboshi M, Masuyama T.
  • Organizer: CVMW2015心血管代謝週間 (第32回国際心臓研究学会日本部会)
  • Place of Presentation: 神戸国際会議場 （兵庫県、神戸市）
  • Year and Date: 2015-12-10
  • Int'l Joint Research
• [Presentation] Cellular Iron Transport Protein, Transferrin Receptor 1 Plays An Important Role In The Pathophysiology Of Chronic Kidney Disease (2015)
  • Author(s): Oboshi M, Naito Y, Sawada H, Iwasaku T, Okuhara Y, Morisawa D, Eguchi A, Nishimura K, Soyama Y, Hirotani S, Mano T, Ishihara M, Tsujino T, Masuyama T.
  • Organizer: American Heart Association Scientific Sessions 2015
  • Place of Presentation: Orange County Convention Center (Orlando, USA)
  • Year and Date: 2015-11-07
  • Int'l Joint Research
• [Presentation] 高血圧における腎臓内鉄代謝異常 (2015)
  • Author(s): 内藤 由朗, 澤田 悠, 大星 真貴子, 辻野 健, 増山 理.
  • Organizer: 第38回日本高血圧学会総会
  • Place of Presentation: ひめぎんホール （愛媛県、松山市）
  • Year and Date: 2015-10-09
• [Presentation] 食事性鉄制限を試みた本態性高血圧症の一例 (2015)
  • Author(s): 大星 真貴子, 内藤 由朗, 澤田 悠, 岩破 俊博, 奥原 祥貴, 森澤 大祐, 江口 明世, 西村 晃一, 廣谷 信一, 真野 敏昭, 石原 正治, 増山 理.
  • Organizer: 第63回日本心臓病学会学術集会
  • Place of Presentation: パシフィコ横浜 （神奈川県、横浜市）
  • Year and Date: 2015-09-18
• [Presentation] ヒト動脈硬化病変におけるトランスフェリンレセプター1 発現について (2015)
  • Author(s): 澤田 悠, 内藤 由朗, 大星 真貴子, 曽山 裕子, 西村 晃一, 江口 明世, 奥原 祥貴, 森澤 大祐, 岩破 俊博, 廣谷 信一, 真野 敏昭, 羽尾 裕之, 光野 正孝, 廣田 誠一, 宮本 裕治, 増山 理.
  • Organizer: 第63回日本心臓病学会学術集会
  • Place of Presentation: パシフィコ横浜 （神奈川県、横浜市）
  • Year and Date: 2015-09-18
• [Presentation] Possible Role of Duodenal Iron Transporters in the Development of Cardiorenal Anemia Syndrome. (2015)
  • Author(s): Naito Y, Sawada H, Oboshi M, Hirotani S, Iwasaku T, Okuhara Y, Morisawa D, Eguchi A, Nishimura K, Mano T, Ishihara M, Masuyama T.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪国際会議場 （大阪府、大阪市）
  • Year and Date: 2015-04-24
• [Presentation] Aortic Iron Overload in Human and Murine Abdominal Aortic Aneurysm (2015)
  • Author(s): Sawada H, Naito Y, Oboshi M, Nishimura K, Eguchi A, Ando T, Morisawa D, Okuhara Y, Iwasaku T, Hirotani S, Mano T, Masuyama T.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪国際会議場 （大阪府、大阪市）
  • Year and Date: 2015-04-24
• [Presentation] Impact of Dietary Iron Restriction on the Thrombosis Formation and Resolution in a Rat Model of Deep Vein Thrombosis (2015)
  • Author(s): Oboshi M, Naito Y, Sawada H, Iwasaku T, Okuhara Y, Morisawa D, Eguchi A, Nishimura K, Hirotani S, Mano T, Tsujino T, Ishihara M, Masuyama T.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪国際会議場 （大阪府、大阪市）
  • Year and Date: 2015-04-24
• [Presentation] Iron Restricted Pair Feeding Attenuates Hypertension and Renal Damage in a Rat Model of Chronic Kidney Disease (2014)
  • Author(s): Yoshiro Naito, Aya Fujii, Hisashi Sawada, Makiko Oboshi, Manami Hosokawa, Toshihiro Iwasaku, Yoshitaka Okuhara, Daisuke Morisawa, Akiyo Eguchi, Shinichi Hirotani, Toshiaki Mano, Takeshi Tsujino, and Tohru Masuyama
  • Organizer: American Heart Association Scientific Sessions 2014
  • Place of Presentation: McCormick Center、シカゴ、USA
  • Year and Date: 2014-11-16 – 2014-11-19
• [Presentation] 腎動脈狭窄モデルにおける鉄制限の効果 (2014)
  • Author(s): 大星真貴子、内藤由朗、澤田 悠、岩破俊博、 奥原祥貴、 森澤大祐、 江口明世、廣谷信一、 真野敏昭、増山 理
  • Organizer: 第62回日本心臓病学会学術集会出席
  • Place of Presentation: 仙台国際センター、仙台
  • Year and Date: 2014-09-26 – 2014-09-28
• [Presentation] 肺高血圧症・右心不全病態形成におけるtransferrin receptor1の関与 (2014)
  • Author(s): 細川愛実、内藤由朗、澤田 悠、大星真貴子、岩破俊博、 奥原祥貴、 森澤大祐、 江口明世、廣谷信一、 真野敏昭、増山 理
  • Organizer: 第62回日本心臓病学会学術集会
  • Place of Presentation: 仙台国際センター、仙台
  • Year and Date: 2014-09-26 – 2014-09-28
• [Presentation] Iron, Hypertension, and Renal Injury in a Rat Model of Chronic Kidney Disease (2014)
  • Author(s): Yoshiro Naito, Hisashi Sawada, Makiko Oboshi, Toshihiro Iwasaku, Yoshitaka Okuhara, Daisuke Morisawa, Akiyo Eguchi, Shinichi Hirotani, Takeshi Tsujino, and Tohru Masuyama
  • Organizer: Joint meeting European Society Hypertension/ International Society Hypertension-Hypertension 2014
  • Place of Presentation: Megaron Athens International Conference Centre, Greece
  • Year and Date: 2014-06-12 – 2014-06-15
• [Presentation] Iron in the Development of Hypertensive Nephropathy (2014)
  • Author(s): Yoshiro Naito, Hisashi Sawada, Makiko Oboshi, Toshihiro Iwasaku, Yoshitaka Okuhara, Daisuke Morisawa, Akiyo Eguchi, Shinichi Hirotani, Takeshi Tsujino, and Tohru Masuyama
  • Organizer: Joint meeting European Society Hypertension/ International Society Hypertension-Hypertension 2014
  • Place of Presentation: Megaron Athens International Conference Centre, Greece
  • Year and Date: 2014-06-12 – 2014-06-15
• [Presentation] Effect of Iron Restriction on Monocrotaline-Induced Pulmonary Vascular Remodeling in Rats (2014)
  • Author(s): Yoshiro Naito, Manami Hosokawa, Hiroyuki Hao, Hisashi Sawada, Makiko Oboshi, Toshihiro Iwasaku, Yoshitaka Okuhara, Daisuke Morisawa, Akiyo Eguchi, Shinichi Hirotani, and Tohru Masuyama
  • Organizer: Joint meeting European Society Hypertension/ International Society Hypertension-Hypertension 2014
  • Place of Presentation: Megaron Athens International Conference Centre, Greece
  • Year and Date: 2014-06-12 – 2014-06-15
• [Presentation] Effects of Iron Restriction on Monocrotaline-induced Pulmonary Vascular Remodeling (2014)
  • Author(s): Yoshiro Naito, Manami Hosokawa , Hiroyuki Hao, Hisashi Sawada, Makiko Oboshi, Toshihiro Iwasaku, Yoshitaka Okuhara, Daisuke Morisawa, Akiyo Eguchi, Shinichi Hirotani, Takeshi Tsujino, and Tohru Masuyama
  • Organizer: American College of Cardiology 63rd Annual Scientific Session 2014
  • Place of Presentation: Washington Convention Center, ワシントン, USA
• [Presentation] Renal Iron Accumulation in Hypertensive Nephropathy of Salt-Loaded Hypertensive Rats (2014)
  • Author(s): Yoshiro Naito, Hisashi Sawada, Makiko Oboshi, Aya Fujii, Shinichi Hirotani, Toshihiro Iwasaku, Yoshitaka Okuhara, Akiyo Eguchi, Daisuke Morisawa, Mitsumasa Ohyanagi, Takeshi Tsujino, and Tohru Masuyama
  • Organizer: 第78回日本循環器学会学術集会
  • Place of Presentation: 東京国際フォーラム、東京
• [Presentation] Dietary Iron Restriction Attenuates the Development of Monocrotaline-Induced Pulmonary Vascular Remodeling and Right Ventricular Failure in Rats (2014)
  • Author(s): Yoshiro Naito, Manami Hosokawa , Hiroyuki Hao, Hisashi Sawada, Makiko Oboshi, Toshihiro Iwasaku, Yoshitaka Okuhara, Daisuke Morisawa, Akiyo Eguchi, Shinichi Hirotani, Takeshi Tsujino, and Tohru Masuyama
  • Organizer: 第18回国際血管生物学会
  • Place of Presentation: みやこめっせ、京都
• [Presentation] モノクロタリン誘発性肺高血圧モデルラットにおける鉄制限の効果 (2013)
  • Author(s): 細川愛実、内藤由朗、羽尾裕之、澤田悠、廣谷信一、岩破俊博、奥原祥貴、森澤大祐、江口明世、辻野 健、増山 理
  • Organizer: 第36回日本高血圧学会総会
  • Place of Presentation: 大阪国際会議場、大阪
• [Book] 循環器内科 高血圧関連疾患と鉄 (2014)
  • Author(s): 内藤 由朗, 増山 理
  • Total Pages: 10
  • Publisher: 科学評論社