| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Outline of Final Research Achievements |
The biological basis of drug resistance against cancer chemotherapy has not been fully elucidated. RBM5 is known to modulate apoptosis and cell cycle arrest but the molecular mechanisms of RBM5 function remains to be examined. We show here that RBM5 modulates the expression of Snail, which is one of transcription factors that regulate epithelial-to-mesenchymal transition (EMT). EMT is a process whereby cells acquire morphologic and molecular alterations facilitating tumor metastasis and progression. Recent reports suggest that EMT contributes to the malignant potentials of cancer cells including the drug resistance. In the present study, we suggest that RBM5 plays important roles in the post-transcriptional regulation of mRNAs that are involved in the chemotherapeutic cellular responses.
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