Effect of gastric acid on the eosinophilic esophagitis
| Project/Area Number |
25460928
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Shimane University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OSHIMA Naoki 島根大学, 医学部, 助教 (10403461)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 食道炎 / 好酸球性食道炎 / 胃酸 / アレルギー / プロトンポンプ阻害薬 / 好酸球 / マウス / ヒト / リンパ球 / 食道 / 逆流性食道炎 / サイトカイン |
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| Outline of Final Research Achievements |
Eosinophilic esophagitis (EoE) is an allergic disease possibly caused by food allergens. However, gastric acid may be an additional cause, since the mucosal disease activity is usually severer in the distal esophagus. In this study, we have investigated the role of gastric acid in the development of EoE. Not only in mouse but also in rat models, induced esophageal gastric acid reflux was found to cause severer esophageal mucosal inflammation in EoE model animals. In human, over 50% of cases with EoE respond to the acid suppression therapy with proton pump inhibitor (PPI). Furthermore, over 50% of PPI-resistant cases with EoE again respond to more potent acid suppression with the administration of vonoprazane. These studies strongly suggest that gastric acid has an important role for the development of EoE.
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Report
(4 results)
Research Products
(47 results)
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[Journal Article] Similarifies and Differences among eosinophilic esophagitis, proton pump inhibitor-responsive esophageal eosinophilia, and reflux esophagitis-Comparisons of clinical, endoscopic, and histopathological findings in Japanese patients-2016
Author(s)
Jiao DJ, Ishimura N, Maruyama R, Ishikawa N, Nagase M, Oshima N, Aimi M, Okimoto E, Mikami H, Ishihara S, Kinoshita Y
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Journal Title
J. Gastrienterol
Volume: 印刷中
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Reliability of symptoms and endoscopic findings for diagnosis of esophageal eosinophilia in a Japanese population2014
Author(s)
Shimura S, Ishimura N, Tanimura T, Yuki T, Miyake T, Kushiyama Y, Sato S, Fujishiro H, Ishihara S, Komatsu T, Kaneto E, Izumi A, Ishikawa N, Maruyama R, Kinoshita Y
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Journal Title
Digestion
Volume: 90
Issue: 1
Pages: 49-57
DOI
Related Report
Peer Reviewed
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[Journal Article] Intra-gastric pH following single oral administrations of rabeprazole and esomeprazole: double-blind cross-over comparison2014
Author(s)
Furuta K, Kohata Y, Fujiwara Y, Sugimoto M, Uotani T, Yamade M, Sahara S, Ichikawa H, Furuta T, Nio K, Iwakiri R, Inamori M, Kawamura O, Kusano M, Kato M, Kawami N, Iwakiri K, Takeuchi T, Higuchi H, Aimi M, Naora K, Fujimoto K, Arakawa T, Kinoshita Y
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Journal Title
Journal of Clinical Biochemistry and Nutrition
Volume: 55
Issue: 3
Pages: 178-183
DOI
NAID
ISSN
0912-0009, 1880-5086
Related Report
Peer Reviewed
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