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Effect of gastric acid on the eosinophilic esophagitis

Research Project

Project/Area Number 25460928
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionShimane University

Principal Investigator

Kinoshita Yoshikazu  島根大学, 医学部, 教授 (30243306)

Co-Investigator(Kenkyū-buntansha) OSHIMA Naoki  島根大学, 医学部, 助教 (10403461)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords食道炎 / 好酸球性食道炎 / 胃酸 / アレルギー / プロトンポンプ阻害薬 / 好酸球 / マウス / ヒト / リンパ球 / 食道 / 逆流性食道炎 / サイトカイン
Outline of Final Research Achievements

Eosinophilic esophagitis (EoE) is an allergic disease possibly caused by food allergens. However, gastric acid may be an additional cause, since the mucosal disease activity is usually severer in the distal esophagus. In this study, we have investigated the role of gastric acid in the development of EoE. Not only in mouse but also in rat models, induced esophageal gastric acid reflux was found to cause severer esophageal mucosal inflammation in EoE model animals. In human, over 50% of cases with EoE respond to the acid suppression therapy with proton pump inhibitor (PPI). Furthermore, over 50% of PPI-resistant cases with EoE again respond to more potent acid suppression with the administration of vonoprazane. These studies strongly suggest that gastric acid has an important role for the development of EoE.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (47 results)

All 2016 2015 2014 2013

All Journal Article (37 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 22 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (4 results) (of which Invited: 1 results) Book (6 results)

  • [Journal Article] Recent Progress in the Research of Eosinophilic Esophagitis and Gastroenteritis.2016

    • Author(s)
      Kinoshita Y, Ishimura N, Oshima N, Mikami H, Okimoto E, Jiao DJ, Ishihara S.
    • Journal Title

      Digestion

      Volume: 93 Issue: 1 Pages: 7-12

    • DOI

      10.1159/000441668

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Suitable biopsy site for detection of esophageal eosinophilia in eosinophilic esophagitis suspected cases2016

    • Author(s)
      Adachi K, Mishiro T, Tanaka S, Kinoshita Y
    • Journal Title

      Digestive Endoscopy

      Volume: 28 Issue: 2 Pages: 139-144

    • DOI

      10.1111/den.12555

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Towards the development of a non-bioptic diagnostic technique for eosinophilic esophagitis using Raman spectroscopy2016

    • Author(s)
      Hemanth Noothalapati, Suguru Uemura, Naoki Ohshima, Yoshikazu Kinoshita, Masahiro, Ando, Hiro-o Hamaguchi, and Tatsuyuki Yamamoto
    • Journal Title

      Vibrational Spectroscopy

      Volume: 85 Pages: 7-10

    • DOI

      10.1016/j.vibspec.2016.03.016

    • NAID

      120005898770

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Eosinophilic, eoshinophilic gastroenteritis and sosinophilic colitis: common mechanisms and differences between Japan and Switzerland2016

    • Author(s)
      Ishihara S, Kinoshita Y, Schoepfer A
    • Journal Title

      Inflammatory Intestinal Diseases

      Volume: 印刷中

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Sustained acid suppression by potassium-competitive acid blocker(P-CAB) may be an attractive treatment condidate for patients with eosinophilic esophagitis2016

    • Author(s)
      Ishimura N, Ishihara S, Kinoshita Y
    • Journal Title

      Am J Gastroenterokl

      Volume: 印刷中

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Similarifies and Differences among eosinophilic esophagitis, proton pump inhibitor-responsive esophageal eosinophilia, and reflux esophagitis-Comparisons of clinical, endoscopic, and histopathological findings in Japanese patients-2016

    • Author(s)
      Jiao DJ, Ishimura N, Maruyama R, Ishikawa N, Nagase M, Oshima N, Aimi M, Okimoto E, Mikami H, Ishihara S, Kinoshita Y
    • Journal Title

      J. Gastrienterol

      Volume: 印刷中

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 好酸球増加症候群.好酸球性食道炎 -小児と成人を含めて-2016

    • Author(s)
      木下芳一,沖本英子,石村典久
    • Journal Title

      別冊日本臨牀 免疫症候群(第2版)

      Volume: 35 Pages: 203-207

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Clinical features of eosinophilic esophagitis: Differences between Asian and Western populations.2015

    • Author(s)
      Ishimura N, Shimura S, Jiao D, Mikami H, Okimoto E, Uno G, Aimi M, Oshima N, Ishihara S, Kinoshita Y
    • Journal Title

      J Gastroenterol Hepatol

      Volume: Suppl 1 Issue: S1 Pages: 1-7

    • DOI

      10.1111/jgh.12746

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Simplified classification of capillary pattern in Barrett esophagus using magnifying endoscopy with narrow band imaging: implications for malignant potential and interobserver agreement.2015

    • Author(s)
      Uno G, Ishimura N, Tada Y, Tamagawa Y, Yuki T, Matsushita T, Ishihara S, Amano Y, Maruyama R, Kinoshita Y
    • Journal Title

      Medicine

      Volume: 94 Issue: 3 Pages: 521-527

    • DOI

      10.1097/md.0000000000000405

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of gene expression profiles in eosinophilic esophagitis (EoE) between Japan and Western countries2015

    • Author(s)
      Shoda T, Morita H, Nomura I, Ishimura N, Ishihara S, Matsuda A, Matsumoto K, Kinoshita Y
    • Journal Title

      Allergology International

      Volume: 64 Issue: 3 Pages: 260-265

    • DOI

      10.1016/j.alit.2015.03.002

    • NAID

      130005482445

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Systematic review: Eosinophilic esophagitis in Asian countries.2015

    • Author(s)
      Kinoshita Y, Ishimura N, Oshima N, Ishihara S
    • Journal Title

      World Journal of Gastroenterology

      Volume: 21 Issue: 27 Pages: 8433-8440

    • DOI

      10.3748/wjg.v21.i27.8433

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 好酸球性消化管障害―好酸球性食道炎と好酸球性胃腸炎―2015

    • Author(s)
      大嶋直樹,木下芳一
    • Journal Title

      アレルギーの臨床

      Volume: 35 Pages: 742-746

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 好酸球浸潤と消化管疾患2015

    • Author(s)
      木下芳一,石原俊治
    • Journal Title

      成人病と生活習慣病

      Volume: 45 Pages: 841-847

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 好酸球性食道炎と好酸球性胃腸炎の診断と治療を知る2015

    • Author(s)
      木下芳一,石村典久,石原俊治
    • Journal Title

      内科

      Volume: 116 Pages: 1150-1154

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 好酸球性消化管疾患診療ガイド2015

    • Author(s)
      木下芳一
    • Journal Title

      消化器内視鏡

      Volume: 27 Pages: 479-482

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 好酸球性胃腸炎2015

    • Author(s)
      大嶋直樹,石原俊治,木下芳一
    • Journal Title

      診断と治療

      Volume: 103 Pages: 665-669

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 好酸球性食道炎を惹起する誘因を特定できるか?2015

    • Author(s)
      木下芳一,石村典久,石原俊治
    • Journal Title

      分子消化器病

      Volume: 12 Pages: 13-18

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
  • [Journal Article] クローン病に合併した好酸球性食道炎の1例2015

    • Author(s)
      宮岡 洋一、塚野 航介、上野さや香、山之内智志、楠  龍策、伊藤 聡子、藤代 浩史、高下 成明、大沼 秀行、木下芳一
    • Journal Title

      Gastroenterological Endoscopy

      Volume: 57

    • NAID

      130004811859

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Relationship between Esophageal Cardiac Glands and Gastroesophageal Reflux Disease2015

    • Author(s)
      Hanada K, Adachi K, Mishiro T, Tanaka S, Takahashi Y, Yoshikawa K, Kinoshita Y
    • Journal Title

      Internal Medicine

      Volume: 54 Issue: 2 Pages: 91-96

    • DOI

      10.2169/internalmedicine.54.3179

    • NAID

      130004903006

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] 好酸球性食道炎・胃腸炎の診断と治療2014

    • Author(s)
      木下 芳一
    • Journal Title

      日本気管食道科学会専門医通信

      Volume: 48 Pages: 6-10

    • NAID

      40020169758

    • Related Report
      2014 Research-status Report
  • [Journal Article] 好酸球性食道炎2014

    • Author(s)
      木下 芳一
    • Journal Title

      日本医事新報

      Volume: 4707 Pages: 52-52

    • Related Report
      2014 Research-status Report
  • [Journal Article] 食物アレルギー研究と診療の最前線2014

    • Author(s)
      海老澤元宏、木下 芳一
    • Journal Title

      Frontiers in Gastroenterology

      Volume: 19 Pages: 3-13

    • Related Report
      2014 Research-status Report
  • [Journal Article] Apoptotic cells ameliorate chronic intestinal inflammation by enhancing regulatory B cell function2014

    • Author(s)
      Ansary Md. Mu, Ishihara S, Oka A, Kusunoki R, Oshima N, Yuki T, Kawashima K, Maegawa H, Kashiwagi N, Kinoshita Y
    • Journal Title

      Inflamm Bowel Dis

      Volume: 20 Issue: 12 Pages: 2308-2320

    • DOI

      10.1097/mib.0000000000000240

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Reliability of symptoms and endoscopic findings for diagnosis of esophageal eosinophilia in a Japanese population2014

    • Author(s)
      Shimura S, Ishimura N, Tanimura T, Yuki T, Miyake T, Kushiyama Y, Sato S, Fujishiro H, Ishihara S, Komatsu T, Kaneto E, Izumi A, Ishikawa N, Maruyama R, Kinoshita Y
    • Journal Title

      Digestion

      Volume: 90 Issue: 1 Pages: 49-57

    • DOI

      10.1159/000365209

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] TGF-β detection and measurement in murine B cells: pros and cons of the different techniques.2014

    • Author(s)
      Mishima Y, Ishihara S, Hansen JJ, Kinoshita Y
    • Journal Title

      Methods Mol Biol

      Volume: 1190 Pages: 71-80

    • DOI

      10.1007/978-1-4939-1161-5_6

    • ISBN
      9781493911608, 9781493911615
    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pathophysiology of Barrett's esophagus-associated neoplasia: circumferential spatial predilection2014

    • Author(s)
      shimura N, Okada M, Mikami H, Okimoto E, Fukuda N, Uno G, Aimi M, Oshima N, Ishihara S, Kinoshita Y
    • Journal Title

      Digestion

      Volume: 89 Issue: 4 Pages: 291-298

    • DOI

      10.1159/000365123

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Intra-gastric pH following single oral administrations of rabeprazole and esomeprazole: double-blind cross-over comparison2014

    • Author(s)
      Furuta K, Kohata Y, Fujiwara Y, Sugimoto M, Uotani T, Yamade M, Sahara S, Ichikawa H, Furuta T, Nio K, Iwakiri R, Inamori M, Kawamura O, Kusano M, Kato M, Kawami N, Iwakiri K, Takeuchi T, Higuchi H, Aimi M, Naora K, Fujimoto K, Arakawa T, Kinoshita Y
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 55 Issue: 3 Pages: 178-183

    • DOI

      10.3164/jcbn.14-41

    • NAID

      130004694546

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Role of regulatory B cells in chronic intestinal inflammation: association with pathogenesis of Crohn's disease2014

    • Author(s)
      Oka A, Ishihara S, Mishima Y, Tada Y, Kusunoki R, Fukuba N, Yuki T, Kawashima K, Matsumoto S, Kinoshita Y
    • Journal Title

      Inflamm Bowel Dis

      Volume: 20 Issue: 2 Pages: 315-28

    • DOI

      10.1097/01.mib.0000437983.14544.d5

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Gastroesophageal acid reflux mainly occurs on the right side of the esophagus.2014

    • Author(s)
      Ishimura N, Ishihara S, Kinshita Y.
    • Journal Title

      Gastrointest Endosc

      Volume: 79 Issue: 1 Pages: 180-181

    • DOI

      10.1016/j.gie.2013.08.004

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] 好酸球性消化管疾患の診断基準2013

    • Author(s)
      木下芳一、大嶋直樹、石村典久、相見正史、石原俊治
    • Journal Title

      胃と腸

      Volume: 48 Pages: 1853-1858

    • Related Report
      2013 Research-status Report
  • [Journal Article] 好酸球性食道炎2013

    • Author(s)
      古田賢司、木下芳一
    • Journal Title

      Medicina

      Volume: 50 Pages: 816-820

    • Related Report
      2013 Research-status Report
  • [Journal Article] 好酸球性消化管障害はなぜ発症するのか2013

    • Author(s)
      石村典久、木下芳一
    • Journal Title

      分子消化器病

      Volume: 10 Pages: 157-165

    • Related Report
      2013 Research-status Report
  • [Journal Article] 好酸球性食道炎2013

    • Author(s)
      木下芳一、相見正史
    • Journal Title

      G.I.Reseach

      Volume: 21 Pages: 263-270

    • Related Report
      2013 Research-status Report
  • [Journal Article] 好酸球性消化管障害の診断と治療2013

    • Author(s)
      木下芳一、大嶋直樹、石村典久、石原俊治
    • Journal Title

      日本消化器病学会雑誌

      Volume: 110 Pages: 953-964

    • NAID

      10031177022

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 好酸球性食道・胃腸炎2013

    • Author(s)
      石村典久、木下芳一
    • Journal Title

      消化器の臨床

      Volume: 16 Pages: 5-14

    • Related Report
      2013 Research-status Report
  • [Journal Article] Case-control study of association of eosinophilic gastrointestinal disorders with <i>Helicobacter pylori</i> infection in Japan2013

    • Author(s)
      Furuta K, Ishimura N, Kinoshita Y, et al.
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 53 Issue: 1 Pages: 60-62

    • DOI

      10.3164/jcbn.13-15

    • NAID

      130004879345

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Limited role of allergy testing in patients with eosinophilic gastrointestinal disorders.2013

    • Author(s)
      Ishimura N, Furuta K, Sato S, et al.
    • Journal Title

      J Gastroenterol Hepatol

      Volume: 28 Issue: 8 Pages: 1306-1313

    • DOI

      10.1111/jgh.12197

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 好酸球性食道炎の内視鏡所見に関する正診率および検者間診断一致率の検討2015

    • Author(s)
      泉大輔,石村典久,三上博信,相見正史,木下芳一
    • Organizer
      第90回日本消化器内視鏡学会総会
    • Place of Presentation
      グランドプリンスホテル新高輪:東京
    • Year and Date
      2015-10-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 好酸球性食道炎における内視鏡検査の意義-当院で経験した44例の解析2015

    • Author(s)
      石村典久,相見正史,木下芳一
    • Organizer
      第89回日本消化器内視鏡学会総会
    • Place of Presentation
      名古屋国際会議場:名古屋
    • Year and Date
      2015-05-31
    • Related Report
      2015 Annual Research Report
  • [Presentation] 好酸球を可視化する~ラマン分光法を用いた好酸球性食道炎の診断~2015

    • Author(s)
      大嶋直樹,石村典久,木下芳一
    • Organizer
      第89回日本消化器内視鏡学会総会
    • Place of Presentation
      名古屋国際会議場:名古屋
    • Year and Date
      2015-05-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] Clinical Characteristics and Diagnosis of Eosinophilic Esophagitis in Asia2014

    • Author(s)
      Kinoshita Y
    • Organizer
      The 5th Asian Postrraduate Course on Neurogastroenterology&Motility
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2013 Research-status Report
    • Invited
  • [Book] 臨床食道学:好酸球性食道炎2015

    • Author(s)
      木下芳一,石村典久
    • Publisher
      南江堂
    • Related Report
      2015 Annual Research Report
  • [Book] 序文:好酸球性消化管疾患診療ガイド(木下 芳一編):2014

    • Author(s)
      木下 芳一
    • Total Pages
      103
    • Publisher
      南江堂
    • Related Report
      2014 Research-status Report
  • [Book] 好酸球性食道炎・胃腸炎の診断と治療:第24回気管食道科専門医大会テキスト(友田 幸一編)2014

    • Author(s)
      木下 芳一
    • Total Pages
      58
    • Publisher
      日本気管食道科学会
    • Related Report
      2014 Research-status Report
  • [Book] カラー版 消化器病学 基礎と臨床(浅香正博、菅野健太郎、千葉 勉、編):好酸球性胃腸炎2013

    • Author(s)
      木下芳一
    • Publisher
      西村書店
    • Related Report
      2013 Research-status Report
  • [Book] 小腸疾患の臨床-最近の進歩(田尻久雄 編):好酸球性胃腸炎2013

    • Author(s)
      大嶋直樹、古田賢司、石原俊治、木下芳一
    • Publisher
      日本メディカルセンター
    • Related Report
      2013 Research-status Report
  • [Book] 消化器疾患最新の治療2013-2014(菅野健太郎、上西紀夫、井廻道夫 編):好酸球性消化管障害2013

    • Author(s)
      木下芳一
    • Publisher
      南江堂
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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