Development of gastric cancer prevention and early cancer detection methods targeting changes in gastric microbiota

Research Project

Project/Area Number	25460932
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Gastroenterology
Research Institution	Osaka City University
Principal Investigator	WATANABE TOSHIO 大阪市立大学, 大学院医学研究科, 准教授 (50336773)
Co-Investigator(Kenkyū-buntansha)	FUJIWARA Yasuhiro 大阪市立大学, 大学院医学研究科, 准教授 (40285292) TOMINAGA Kazunari 大阪市立大学, 大学院医学研究科, 准教授 (80336768) TANIGAWA Tetsuya 大阪市立大学, 大学院医学研究科, 講師 (70423879)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000) Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	胃細菌叢 / 胃癌 / ピロリ菌 / マイクロバイオーム / 胃がん / 次世代シークエンサー / 細菌叢
Outline of Final Research Achievements	The Aim of this study is to clarify the role of the gastric microbiota using the 16S rRNA method. In this study, we especially focused on not only H.pylori infection but also other bacterial infections. We demonstrated that there are a lot of species other than H.pylori in the gastric mucosa. Interestingly, in some samples, H.pylori were not major component in the gastric mucosa which was obtained from H.pylori infected patients. Father studies are required to clarify the relationship between gastric carcinogenesis and involvement of the other bacterial species.