| Project/Area Number |
25460935
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUI Hidenori 北里大学, 北里生命科学研究所, 講師 (30219373)
TAKAHASHI Tetsufumi 北里大学, 薬学部, 助教 (40449004)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 胃MALTリンパ腫 / 幹細胞 / 微小循環系 / 自律神経 / ハイルマニイ菌 / 胃マルトリンパ腫 / サブスタンスP / VEGF / Vasohibin-2 / Helicobacter heilmannii / マルトリンパ腫 / へリコバクターハイルマニイ / 微小循環 / ヘリコバクター属 / 腫瘍幹細胞 / c-Met / substance P |
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| Outline of Final Research Achievements |
The relation of stem cells, microcirculatory system and autonomic nervous system to the formation and progress of the gastric MALT lymphoma has been investigated mainly from the viewpoint of substance P and angiogenesis. In the Helicobacter heilmannii-infected mouse model, substance P containing nerves and its receptors has been found to be richly distributed in the MALT lymphoma tissues, especially near the afferent arterioles, efferent venules and lymphocytes including the stem cells of the lymphoma. The effect of the substance P antagonists also support the significance of autonomic nerves in the regulation of MALT lymphoma. In the clinical cases, the similar distribution of the nerves and the receptors has been detected. In addition, the administration of axitinib, one of the multiple tyrosine kinase inhibitors, revealed the reciprocal regulation of vasohibin 2 and VEGF in the progress of the gastric MALT lymphoma.
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