Relation of stem cell niche and microcirculation in MALT lymphoma
Project/Area Number |
25460935
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | Kitasato University |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
MATSUI Hidenori 北里大学, 北里生命科学研究所, 講師 (30219373)
TAKAHASHI Tetsufumi 北里大学, 薬学部, 助教 (40449004)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | 胃MALTリンパ腫 / 幹細胞 / 微小循環系 / 自律神経 / ハイルマニイ菌 / 胃マルトリンパ腫 / サブスタンスP / VEGF / Vasohibin-2 / Helicobacter heilmannii / マルトリンパ腫 / へリコバクターハイルマニイ / 微小循環 / ヘリコバクター属 / 腫瘍幹細胞 / c-Met / substance P |
Outline of Final Research Achievements |
The relation of stem cells, microcirculatory system and autonomic nervous system to the formation and progress of the gastric MALT lymphoma has been investigated mainly from the viewpoint of substance P and angiogenesis. In the Helicobacter heilmannii-infected mouse model, substance P containing nerves and its receptors has been found to be richly distributed in the MALT lymphoma tissues, especially near the afferent arterioles, efferent venules and lymphocytes including the stem cells of the lymphoma. The effect of the substance P antagonists also support the significance of autonomic nerves in the regulation of MALT lymphoma. In the clinical cases, the similar distribution of the nerves and the receptors has been detected. In addition, the administration of axitinib, one of the multiple tyrosine kinase inhibitors, revealed the reciprocal regulation of vasohibin 2 and VEGF in the progress of the gastric MALT lymphoma.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Helicobacter suis-Infected Nodular Gastritis and a Review of Diagnostic Sensitivity for Helicobacter heilmannii-Like Organisms2015
Author(s)
Sasaki, M., Goji, S., Tamura, Y., Nakamura, M., Matsui, H., Murayama, S.Y., Ebi, M., Ogasawara, N., Funai, Y. and Kasugai, K.
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Journal Title
Case Rep Gastroenterol
Volume: 9
Issue: 2
Pages: 179-187
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] New Pharmaceutical Treatment of Gastric MALT Lymphoma: Anti-angiogenesis Treatment using VEGF Receptor Antibodies and Celecoxib.2014
Author(s)
Nakamura, M., Takahashi, T., Matsui, H., Takahashi, S., Murayama, S. Y., Suzuki, H., Tsuchimoto, K.
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Journal Title
Current pharmaceutical design
Volume: 20
Issue: 7
Pages: 1097-1103
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Alteration of angiogenesis in Helicobacter-heilmannii-induced MALT lymphoma: interaction with c-Met and HGF.2014
Author(s)
Nakamura, M., Takahashi, T., Matsui, H., Baniwa, Y., Takahashi, S., Murayama, S.Y., Serizawa, H., Suzuki, H., Hibi, T.
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Journal Title
J. Gastroenterol. Hepatol.
Volume: 29
Issue: S4
Pages: 70-76
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] New Pharmaceutical Treatment of Gastric MALT Lymphoma: Anti-angiogenesis Treatment using VEGF Receptor Antibodies and Celecoxib2014
Author(s)
Nakamura, M., Takahashi, T., Matsui, H., Takahashi, S., Murayama, S.Y., Suzuki, H, Tsuchimoto, K
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Journal Title
Current pharmaceutical design
Volume: 20
Pages: 1097-1103
Related Report
Peer Reviewed
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[Presentation] Unexpected high prevalence of Helicobacter heilmannii-like organisms in H. pylori negative patients with gastric diseases in Japan2015
Author(s)
Anders Overby, , Somay Y. Murayama, Hidenori Matsui, Tetsufumi Takahashi, Shinichi Takahashi, Hidekazu Suzuki, Tatsuhiro Mabe, Hiroshi Araki, Yuuichi Sato, Masahiko Nakamura
Organizer
3rd International consensus symposium on Helicobacter heilmannii/suis (2015 AKPS Joint Symposium)
Place of Presentation
北里大学薬学部、東京都
Year and Date
2015-06-29
Related Report
Int'l Joint Research
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[Presentation] MALT Lymphoma Stem Cell and its Niche in Helicobacter heilmannii-infected Mice Stomach2013
Author(s)
Nakamura, M., Matsui, H., Takahashi, T., Takahashi, S., Hibi, T. and Tsuchimoto, K.
Organizer
Experimental Biology
Place of Presentation
Boston, MA, USA
Related Report
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[Book] Helicobacter pylori2016
Author(s)
Masahiko Nakamura, Anders Overby, Somay Y Murayama, Hidekazu Suzuki, Tetsufumi Takahashi, Shinichi Takahashi, Hidenori Matsui.
Total Pages
267
Publisher
Springer
Related Report
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