| Project/Area Number |
25460941
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Gunma University |
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Principal Investigator |
Kakizaki Satoru 群馬大学, 大学院医学系研究科, 講師 (80344935)
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| Co-Investigator(Kenkyū-buntansha) |
山崎 勇一 群馬大学, 医学部附属病院, 助教 (00582404)
堀口 昇男 群馬大学, 医学部附属病院, 助教 (10550022)
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| Co-Investigator(Renkei-kenkyūsha) |
YOSHINARI Kouichi 静岡県立大学, 大学院薬学系研究科, 教授 (60343399)
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| Research Collaborator |
TAKIZAWA Daichi 群馬大学, 大学院医学系研究科, 大学院生
TOJIMA Hiroki 群馬大学, 大学院医学系研究科, 大学院生
TAHARA Hiroki 群馬大学, 大学院医学系研究科, 大学院生
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 炎症性腸疾患 / 核内レセプター / ＰＸＲ / ＣＡＲ / ＤＳＳ腸炎 / 炎症性サイトカイン / CAR / PXR / DSS腸炎 / 核内受容体 |
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| Outline of Final Research Achievements |
The aim of this study was to investigate the role of nuclear receptors PXR and CAR in the pathogenesis of inflammatory bowel diseases (IBD), including ulcerative colitis and Crohn's disease. Wild-type, Pxr-null, Car-null, and Pxr/Car-double null mice were treated with a PXR/CAR agonist or vehicle in a dextran sodium sulfate (DSS)-induced IBD model. PXR and CAR ameliorate DSS-induced ulcerative colitis model via inhibiting inflammatory cytokines and apoptosis.PXR and CAR agonists are promising agents for the treatment of IBD.
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