Analysis of the pathogenesis in CD using mapping biopsy from entire small intestine
| Project/Area Number |
25460945
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
Araki Akihiro 東京医科歯科大学, 医学部附属病院, 准教授 (80361690)
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| Co-Investigator(Kenkyū-buntansha) |
TSUCHIYA Kiichiro 東京医科歯科大学, 大学院医歯学総合研究科, 准教授 (40376786)
WATANABE Mamoru 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (10175127)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | バルーン内視鏡 / マッピング生検 / 潜在的炎症 / クローン病 |
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| Outline of Final Research Achievements |
In this study, we aimed to understand entire small enteral environment in the Crohn’s disease (CD). Mapping biopsy from entire small intestine in CD patients by a balloon endoscope. As a result, it was suggested that potential inflammation spread throughout ileum in CD. We found that the HD-6 producing cells were decreased in CD,a dysfunction of the gastrointestinal barrier ability was suggested in CD. Furthermore, I performed the molecular mechanism for the expression of HD6 and found that β catenin and Atoh1 controlled transcription activity of HD6.
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Report
(4 results)
Research Products
(12 results)
