Control of intestinal mucosal defense system through IL-22 production: Crosstalk between IEL and IEC
| Project/Area Number |
25460948
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
Sugimoto Ken 浜松医科大学, 医学部, 准教授 (20529507)
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| Co-Investigator(Kenkyū-buntansha) |
大澤 恵 浜松医科大学, 医学部附属病院, 講師 (10397391)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | IL-22 / IEL / 難治性小腸潰瘍 / 粘膜防御機構 |
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| Outline of Final Research Achievements |
It is well known that IL-22 enhances the barrier mechanism of intestinal mucosa and is deeply involved in inflammatory response control, but it is not known whether it is involved in the mucosal defense mechanism of intractable ulcerative lesions in the small intestine. We confirmed that IEL isolated from mouse produces IL-22 and activates STAT 3 of small intestinal epithelial cells. In addition, in order to investigate the regulatory mechanism of IL-22 production in the small intestine and involvement in the mucosal defense mechanism against small intestinal epithelial cells, it was investigated whether IL-22 produced by IEL could improve mucosal damage of the small intestine induced by indomethacin by using the indomethacin-induced small intestine injury mouse model.
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Report
(5 results)
Research Products
(38 results)
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[Journal Article] Influence of Prostate Stem Cell Antigen Gene Polymorphisms on Susceptibility to Helicobacter pylori-associated Diseases: A Case-control Study2015
Author(s)
97.Ichikawa H, Sugimoto M, Uotani T, Sahara S, Yamade M, Iwaizumi M, Yamada T, Osawa S, Sugimoto K, Miyajima H, Yamaoka Y, Furuta T.
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Journal Title
Helicobacter
Volume: 20
Issue: 2
Pages: 106-113
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Prevention ofgastricmucosal injuryinduced by anti-platelet drugs by famotidine2014
Author(s)
Uotani T, Sugimoto M, Nishino M, Ichikawa H, Sahara S, Yamade M, Iwaizumi M, Yamada T, Osawa S, Sugimoto K, Umemura K, Watanabe H, Miyajima H, Furuta T
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Journal Title
J Clin Pharmacol
Volume: (Epub ahead of print)
Issue: 8
Pages: 858-864
DOI
Related Report
Peer Reviewed
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[Journal Article] Sitafloxacin-based third-line rescue regimens for Helicobacter pylori infection in Japan2014
Author(s)
Furuta T, Sugimoto M, Kodaira C, Nishino M, Yamade M, Uotani TSahara S, Ichikawa H, Yamada T, Osawa S, Sugimoto K, Watanabe H, Umemura K.
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Journal Title
J Gastroenterol Hepatol
Volume: 29
Issue: 3
Pages: 487-493
DOI
Related Report
Peer Reviewed / Open Access
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