Relationship between the recruitment of hematopoietic cell-derived cancer-associated fibroblasts by MCP-1 or tenascin C and the development of colon cancer
Project/Area Number |
25460951
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | Mie University |
Principal Investigator |
MASUYA MASAHIRO 三重大学, 医学(系)研究科(研究院), 准教授 (30281083)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | monocyte / MCP-1 / fibrocyte / colon cancer / 造血細胞 / 大腸癌 / 癌関連線維芽細胞 / 線維細胞 / ARB / AOM/DSS |
Outline of Final Research Achievements |
It is well known that several kinds of hematopoietic cells infiltrate the colon and form tumor microenvironment in inflammatory colitis. The cells, which have received the most attention as a key player in the microenvironment, are cancer-associated fibroblasts (CAFs). Because we have previously identified that monocytes enter the injured organs through MCP-1/CCR2 axis and differentiate into fibroblasts or myofibroblasts, we hypothesize that CAFs also are derived from monocytes. In C57BL/6J-Ly5.1 mice transplanted with EGFP+ bone marrow cells, EGFP+ fibrocytes and fibroblasts along with the inflammatory cells increased in the injured colon in association with progression of inflammation after AOM/DSS treatment. The increment of those cells was related to the formation of colon tumors. Angiotensin II receptor blocker, which exhibits antagonistic effects against CCR2, inhibited the progression of both colon fibrosis and tumor formation.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Recurrent inflammatory aortic aneurysms in chronic mucocutaneous candidiasis with a gain-of-function STAT1 mutation2015
Author(s)
Tanimura M, Dohi K, Hirayama M, Sato Y, Sugiura E, Nakajima H, Kanemitsu S, Toyoda H, Yamada N, Masuya M, Imanaka-Yoshida K, Shimpo H, Azuma E, Ito M
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Journal Title
Int J Cardiol
Volume: 196
Pages: 88-90
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Interleukin-17 Induces an Atypical M2-Like Macrophage Subpopulation That Regulates Intestinal Inflammation.2014
Author(s)
Nishikawa K, Seo N, Torii M, Ma N, Muraoka D, Tawara I, Masuya M, Tanaka K, Takei Y, Shiku H, Katayama N, Kato T.
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Journal Title
PLOS ONE
Volume: 9
Issue: 9
Pages: e108494-e108494
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Tacrolimus-induced left ventricular apical hypertrophy in a patient with post-allogeneic hematopoietic stem cell transplantation2014
Author(s)
Takeuchi T, Ino K, Dohi K, Monma F, Nakamori S, Fujieda A, Yamada N, Nakamura M, Masuya M, Katayama N, Ito M
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Journal Title
Int J Cardiol
Volume: 177
Issue: 1
Pages: e22-e24
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Splenectomy increases the number of circulating hematopoietic stem/progenitor cells in patients with hepatitis C virus-associated liver cirrhosis2014
Author(s)
Masuya M, Shiraki K, Sugimoto K, Yamamoto N, Yoneda M, Kanayama K, Nishikawa K, Ino K, Tawara I, Ohishi K, Sakurai H, Usui M, Shiraishi T, Isaji S, Takei Y and Katayama N
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Journal Title
Hepatology Research
Volume: 44
Issue: 14
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Manipulation of human early T lymphopoiesis by coculture on human bone marrow stromal cells: Potential utility for adoptive immunotherapy2013
Author(s)
Liu B, Ohishi K, Orito Y,N a k a mo r i Y, Nishikawa H, Ino K,Suzuki K, Matsumoto T,Masuya M,Hamada H, Mineno J, Ono R, Nosaka T, Shiku H, Katayama N.
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Journal Title
Exp Hematol
Volume: -
Issue: 4
Pages: 367-376
DOI
Related Report
Peer Reviewed
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[Journal Article] Clinical utility of a panfungal polymerase chain reaction assay for invasive fungal diseases in patients with haematologic disorders.2013
Author(s)
Sugawara Y, Nakase K, Nakamura A, Ohishi K, Sugimoto Y, Fujieda A, Monma F, Suzuki K, Masuya M, Matsushima Y, Wada H, Nobori T, Katayama N.
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Journal Title
Eur J Haematol.
Volume: 90
Issue: 4
Pages: 331-339
DOI
Related Report
Peer Reviewed
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