| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
It is well known that several kinds of hematopoietic cells infiltrate the colon and form tumor microenvironment in inflammatory colitis. The cells, which have received the most attention as a key player in the microenvironment, are cancer-associated fibroblasts (CAFs). Because we have previously identified that monocytes enter the injured organs through MCP-1/CCR2 axis and differentiate into fibroblasts or myofibroblasts, we hypothesize that CAFs also are derived from monocytes. In C57BL/6J-Ly5.1 mice transplanted with EGFP+ bone marrow cells, EGFP+ fibrocytes and fibroblasts along with the inflammatory cells increased in the injured colon in association with progression of inflammation after AOM/DSS treatment. The increment of those cells was related to the formation of colon tumors. Angiotensin II receptor blocker, which exhibits antagonistic effects against CCR2, inhibited the progression of both colon fibrosis and tumor formation.
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