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Causal gene for chronic nonspecific multiple ulcers of the small intestine

Research Project

Project/Area Number 25460953
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionKyushu University

Principal Investigator

Umeno Junji  九州大学, 大学病院, 助教 (70621704)

Co-Investigator(Kenkyū-buntansha) MORIYAMA Tomohiko  九州大学, 大学院病態機能内科学, 助教 (20452758)
ESAKI Motohiro  九州大学, 大学院病態機能内科学, 講師 (50335957)
松本 主之  岩手医科大学, 医学部, 教授 (10278955)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords小腸潰瘍症 / プロスタグランジン / 小腸潰瘍 / SLCO2A1 / 非特異性多発性小腸潰瘍症 / エクソームシークエンス / 次世代シーケンサー / 常染色体劣性遺伝 / 小腸疾患
Outline of Final Research Achievements

By using exome sequencing loss-of-function mutations in the SLCO2A1 gene encoding a prostaglandin transporter cause the hereditary enteropathy; chronic nonspecific multiple ulcers of the small intestine. We suggest a more
appropriate nomenclature of “chronic enteropathy associated with SLCO2A1 gene” (CEAS). CEAS and primary hypertrophic osteoarthropathy share a causative gene and that their clinical features are profoundly influenced by other modifiers.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (5 results)

All 2015 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (4 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] A Hereditary Enteropathy Caused by Mutations in the SLCO2A1 Gene, Encoding a Prostaglandin Transporter.2015

    • Author(s)
      Umeno J, Hisamatsu T, Esaki M, Atsushi Hirano A, Kubokura N, Asano K, Kochi S, Yanai S, Fuyuno Y, Shimamura K, Hosoe N, Ogata H, Watanabe T, Aoyagi K, Ooi H, Watanabe K, Yasukawa S, Hirai F, Matsui T, Iida M, Yao T, Hibi T, Kosaki K, Kanai T, Kitazono T, Matsumoto T.
    • Journal Title

      PLoS Genetics

      Volume: Nov 5;11(11): Issue: 11 Pages: 1-15

    • DOI

      10.1371/journal.pgen.1005581

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Chronic enteropathy associated with SLCO2A1 gene, encoding prostaglandin transporter (CEAS)2015

    • Author(s)
      Junji Umeno, Tadakazu Hisamatsu, Motohiro Esaki, Atsushi Hirano, Shuji Kochi, Kenji Watanabe, Kunihiko Aoyagi, Fumihito Hirai, Toshiyuki Matsui, Tsuneyoshi Yao, Toshifumi Hibi, Takanori Kanai, Takayuki Matsumoto, Takanari Kitazono
    • Organizer
      2015 Advances in Inflammatory Bowel Diseases: Crohn's & Colitis Foundation of America's Clinical & Research Conference
    • Place of Presentation
      オーランド
    • Year and Date
      2015-12-11
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 非特異性多発性小腸潰瘍症の原因遺伝子の同定2015

    • Author(s)
      梅野淳嗣、江崎幹宏、松本主之
    • Organizer
      第101回消化器病学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2015-04-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] 非特異性多発性小腸潰瘍症の原因遺伝子の同定2015

    • Author(s)
      梅野淳嗣、江崎幹宏、松本主之
    • Organizer
      第101回 日本消化器病学会総会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2015-04-23
    • Related Report
      2014 Research-status Report
  • [Presentation] 全エクソンシーケンスによる非特異性多発性小腸潰瘍症の原因遺伝子同定2014

    • Author(s)
      梅野淳嗣、江崎幹宏、松本主之
    • Organizer
      第22回 日本消化器関連学会週間
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2014-10-24
    • Related Report
      2014 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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