Advances in refractory IBD treatment: a new therapeutic target, Annexin A2

• Project/Area Number: 25460957
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Nagoya City University
• Principal Investigator: Tanida Satoshi 名古屋市立大学, 医学(系)研究科(研究院), 講師 (30528782)
• Co-Investigator(Kenkyū-buntansha): JOH Takashi 名古屋市立大学, 大学院医学研究科, 教授 (30231369)
• Co-Investigator(Renkei-kenkyūsha): HIGASHIYAMA Shigeki 愛媛大学, 大学院医学系研究科, 教授 (60202272)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: TNF-α / ADAM17 / Annexin A2 / TNFα / Annexin A2 / 炎症性腸疾患 / TNF-alfa

Outline of Final Research Achievements

Inhibition of Annexin A2 may be a new therapeutic strategy for the prevention of TNF-α shedding during inflammatory bowel disease inflammation.We try to propose the potential of Annexin A2 as a new molecular target for the treatment of IBD by using Annexin A2 knockout mouse. Annexin A2 knockout mouse cannnot be established becase chimera mouse's genital organ was immature. Annexin A2 is likely to be associated with mouse's genital organ formation.

Research Products

• [Journal Article] Advances in refractory ulcerative colitis treatment: A new therapeutic target, Annexin A2. (2015)
  • Author(s): Tanida S, Mizoshita T, Ozeki K, Katano T, Kataoka H, Kamiya T, Joh T.
  • Journal Title: World J Gastroenterol. Volume: 21 Issue: 29 Pages: 8776-8786
  • DOI: 10.3748/wjg.v21.i29.8776
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 腸管ベーチェット病に対するアダリムマブの長期効果 (2016)
  • Author(s): 谷田諭史
  • Organizer: 第12回日本消化管学会総会学術集会
  • Place of Presentation: 京王プラザホテル(東京都新宿区）
  • Year and Date: 2016-02-26
• [Remarks] A new therapeutic target, Annexin A2
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/26269667