| Project/Area Number |
25460959
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Gastroenterology
|
|---|
| Research Institution | Kyoto Prefectural University of Medicine |
|---|
Principal Investigator |
Tomohisa Takagi 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (70405257)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
Naito Yuji 京都府立医科大学, 医学研究科, 准教授 (00305575)
Katada Kazuhiro 京都府立医科大学, 医学研究科, 助教 (60593910)
|
|---|
| Research Collaborator |
Mizushima Katsura
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | Heme oxygenase / 一酸化炭素 / マクロファージ / リンパ球 / Heme oxygenase-1 |
|---|
| Outline of Final Research Achievements |
In this research, we investigated the role of heme oxygenase-1 (HO-1) and carbon monoxide (CO), which is a by-product of HO-1, in intestinal inflammation. In results, we confirmed that HO-1 highly expressing macrophages expressed M2 marker, and CO regulated Th1/Th17 differentiation of lymphocytes. Thus, HO-1 and CO might regulate intestinal immune system.
|
