Iron overload by iron metabolism dysregulation and UPR breakdown through the ER stress
Project/Area Number |
25460969
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | Asahikawa Medical College |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
SASAKI Katsunori 旭川医科大学, 医学部, 特任教授 (60336394)
TANAKA Hiroki 旭川医科大学, 医学部, 助教 (70596155)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | 脂肪肝 / 鉄代謝異常 / 小胞体ストレス / UPR |
Outline of Final Research Achievements |
Non-alcoholic fatty liver disease frequently coexist iron overload. Iron dysregulation by hepcidin down-regulation is considered to be the cause as same as hereditary heamochromatosis. Bone morphogenetic protein binding endothelial regulator (BMPER) is inhibiting BMP-SMAD signaling by binding BMP extracellularly, subsequently reduces hepcidin transcription. Although BMPER was thought to be expressed by hepatocytes because of its vast protein expressing functions, it is noteworthy that we found out BMPER is expressed dominantly in liver sinusoid endothelial cells rather than hepatocytes.
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] Polyphosphate, an active molecule derived from probiotic Lactobacillus brevis, improves the fibrosis in murine colitis.2015
Author(s)
Kashima S, Fujiya M, Konishi H, Ueno N, Inaba Y, Moriichi K, Tanabe H, Ikuta K, Ohtake T, Kohgo Y.
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Journal Title
Transl Res.
Volume: in press
Issue: 2
Pages: 00069-9
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Hepatic nerve growth factor induced by iron overload triggers defenestration in liver sinusoidal endothelial cells.2015
Author(s)
Addo L, Tanaka H, Yamamoto M, Toki Y, Ito S, Ikuta K, Sasaki K, Ohtake T, Torimoto Y, Fujiya M, Kohgo Y.
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Journal Title
Biochim Biophys Acta
Volume: 1852(1)
Issue: 1
Pages: 175-83
DOI
Related Report
Peer Reviewed
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[Journal Article] Up-regulation of iron regulatory hormone hepcidin by interferon α.2014
Author(s)
Ichiki K, Ikuta K, Addo L, Tanaka H, Sasaki Y, Shimonaka Y, Sasaki K, Ito S, Shindo M, Ohtake T, Fujiya M, Torimoto Y, Kohgo Y.
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Journal Title
Journal of Gastroenterology and Hepatology
Volume: 29
Issue: 2
Pages: 387-394
DOI
Related Report
Peer Reviewed
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