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Exosomal transfer of functional RNA in hepatocellular carcinoma cell proliferation

Research Project

Project/Area Number 25460971
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionTohoku University

Principal Investigator

Kogure Takayuki  東北大学, 大学病院, 助教 (70400330)

Co-Investigator(Kenkyū-buntansha) KONDO Yasuteru  東北大学, 医学系研究科, 非常勤講師 (70455822)
KAKAZU Eiji  東北大学, 高度教養教育・学生支援機構, 助教 (20509377)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords肝細胞癌 / エキソソーム / 機能性RNA
Outline of Final Research Achievements

Ultraconserved RNAs are long non-coding RNAs transcribed from ultraconserved elements (UCEs), which are defined as genomic sequences with 100% conservation between human, mouse and rat with length of more than 200 bases and dysregulation of ultraconserved RNAs are reported in many types of cancers. We investigated the exosomal transfer of ultraconserved RNAs in hepatocellular carcinoma.
We identified several ultraconserved RNAs up-regulated in exosomes derived from hepatocellular carcinoma cell lines by using a custom PCR array plate and one of the ultraconserved RNAs were involved in the proliferation of hepatocellular carcinoma cells. We also identified an ultraconserved RNA differentially expressed in human hepatocellular carcinoma tissues.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (1 results)

All 2016

All Presentation (1 results)

  • [Presentation] 肝細胞癌における細胞間コミュニケーションの新規機序 細胞外分泌顆粒を介したlong non-coding RNAの細胞間輸送2016

    • Author(s)
      小暮貴之
    • Organizer
      第52回日本肝臓学会総会
    • Place of Presentation
      ホテルニューオータニ幕張 千葉
    • Year and Date
      2016-05-21
    • Related Report
      2015 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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