| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
Ultraconserved RNAs are long non-coding RNAs transcribed from ultraconserved elements (UCEs), which are defined as genomic sequences with 100% conservation between human, mouse and rat with length of more than 200 bases and dysregulation of ultraconserved RNAs are reported in many types of cancers. We investigated the exosomal transfer of ultraconserved RNAs in hepatocellular carcinoma.
We identified several ultraconserved RNAs up-regulated in exosomes derived from hepatocellular carcinoma cell lines by using a custom PCR array plate and one of the ultraconserved RNAs were involved in the proliferation of hepatocellular carcinoma cells. We also identified an ultraconserved RNA differentially expressed in human hepatocellular carcinoma tissues.
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