amino acids metabolism and immune abnormality in non alcoholic steatohepatitis
| Project/Area Number |
25460972
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Tohoku University |
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Principal Investigator |
KAKAZU Eiji 東北大学, 高度教養教育・学生支援機構, 助教 (20509377)
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| Co-Investigator(Kenkyū-buntansha) |
KOGURE Takayuki 東北大学, 病院, 助教 (70400330)
KONDO Yasuteru 東北大学, 医学系研究科, 非常勤講師 (70455822)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 非アルコール性脂肪性肝炎 / メタボローム解析 / 門脈血 |
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| Outline of Final Research Achievements |
We elucidated the differences of metabolite profiles in portal blood between normal mice and fatty liver genetic model mice (ob/ob and kk-Ay) by CE-TOFMS. The top 5% metabolites of portal blood that were higher in ob/ob compared to wild-type were Trimethylamine N-oxide (TMAO), phenaceturic acid, isethionic acid, 3-Indoxylsulfuric acid and pipecolic acid. Furthermore, It is possible that TMAO or Trimethylamine (TMA) which is metabolized from TMAO, progress steatosis.
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Report
(4 results)
Research Products
(8 results)
