The role of macrophage inhibitory factor (MIF) in NASH

• Project/Area Number: 25460976
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Gunma University
• Principal Investigator: HORIGUCHI NORIO 群馬大学, 医学部附属病院, 助教 (10550022)
• Co-Investigator(Kenkyū-buntansha): 山田 英二郎 群馬大学, 医学部附属病院, 助教 (60645563) ; 柿崎 暁 群馬大学, 大学院医学系研究科, 講師 (80344935)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: MIF / NASH / 肝線維化 / 脂質沈着 / 線維化 / 肝癌 / 非アルコール性脂肪性肝炎 / マクロファージ遊走阻止因子 / 高脂肪食 / MIF マクロファージ遊走阻止因子 / NASH 非アルコール性脂肪性肝炎 / 肝腫瘍 / ＭＩＦ（マクロファージ遊走阻止因子）

Outline of Final Research Achievements

Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine, which is involved in inflammatory response and regulates macrophage accumulation. However, the precise role of MIF in NAFLD is not clear. In this study, we have shown MIF plays an important role in the hepatic steatosis and fibrosis in high fat diet mode. These results suggest MIF might be the therapeutic target against non-alcoholic liver diseases.

Research Products

• [Journal Article] Prevalence of nonalcoholic steatohepatitis in Japanese patients with morbid obesity undergoing bariatric surgery. (2016)
  • Author(s): Seki Y, Kakizaki S, Horiguchi N, Hashizume H, Tojima H, Yamazaki Y, Sato K, Kusano M, Yamada M, Kasama K.
  • Journal Title: J Gastroenterol. Volume: 51 Issue: 3 Pages: 281-289
  • DOI: 10.1007/s00535-015-1114-8
  • Peer Reviewed
• [Journal Article] MK-0626, a selective DPP-4 inhibitor, attenuates hepatic steatosis in ob/ob mice. (2014)
  • Author(s): Ohyama T, Sato K, Yamazaki Y, Hashizume H, Horiguchi N, Kakizaki S, Mori M, Kusano M, Yamada M.
  • Journal Title: World J Gastroenterol Volume: 20 Issue: 43 Pages: 16227-35
  • DOI: 10.3748/wjg.v20.i43.16227
  • Peer Reviewed / Open Access
• [Journal Article] A prospective study of long-term outcomes in female patients with nonalcoholic steatohepatitis using age- and body mass index-matched cohorts. (2013)
  • Author(s): Hashizume et al
  • Journal Title: Acta Med Okayama. Volume: 67 Pages: 45-53
  • Peer Reviewed
• [Journal Article] Transforming growth factor-α activates pancreatic stellate cells and may be involved in matrix metalloproteinase-1 upregulation. (2013)
  • Author(s): Tahara et al.
  • Journal Title: Lab Invest. Volume: 93 Pages: 720-732
  • Peer Reviewed
• [Presentation] Malignant peripheral Nerve tumor of liver. (2015)
  • Author(s): Horiguchi N, Kakizaki S,Takizawa D, Yamazaki Y, Sato K, Ohno Y, Kusano M, Yamada M.
  • Organizer: 第２５回アジア大西洋消化器病学会
  • Place of Presentation: Taipei Taiwan
  • Year and Date: 2015-12-03
  • Int'l Joint Research
• [Presentation] Macrophage migration inhibitory factor (MIF) attenuates liver inflammation, steatosis, and fibrosis in murine non-alcoholic liver disease model (2013)
  • Author(s): Horiguchi et al.
  • Organizer: 2013年米国肝臓学会
  • Place of Presentation: Washington DC