Clinical and virological conditions of HBe antigen negative hepatitis B

• Project/Area Number: 25460986
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Shinshu University
• Principal Investigator: TANAKA Eiji 信州大学, 学術研究院医学系, 教授 (50163506)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: B型肝炎 / HBe抗原 / セロコンバージョン / HBcr抗原 / Mac-2 binding protein / 肝線維化 / 肝細胞癌 / B型慢性肝炎 / ウイルス変異 / HBV DNA / HBs抗原

Outline of Final Research Achievements

Patients with HBe antigen negative hepatitis B tend to show severe hepatitis, and thus tend to develop cirrhosis and hepatocellular carcinoma. We analyzed clinical and virological conditions of such patients in this study, and obtained the following three conclusions. The first, ALT abnormality after 2 years of seroconversion (SC) may be evaluated as HBeAg-negative hepatitis. ALT, HBV DNA and HBcrAg levels may be useful in predicting the outcome of patients who showed HBeAg SC. The second, there is an opposite association of the pre-core mutation with viral load before and after HBeAg seroconversion in patients with HBV infection. The third, WFA+-M2BP level is useful to predict levels of hepatic fibrosis and risks of hepatocarcinogenesis. Those results may be beneficial to improve prognosis of patients with HBe antigen negative hepatitis B.

Research Products

• [Journal Article] Serum Wisteria floribunda agglutinin-positive human Mac-2 binding protein may predict liver fibrosis and progression to hepatocellular carcinoma in patients with chronic hepatitis B virus infection (2016)
  • Author(s): Ichikawa Y, Joshita S, Umemura T, Shobugawa Y, ShibataS, Yamazaki T, Fujimori N, Komatsu M, Matsumoto A, Tanaka E
  • Journal Title: Hepatology Research Volume: in press
  • Peer Reviewed
• [Journal Article] Mutations of pre-core and basal core promoter before and after hepatitis B e antigen seroconversion. (2015)
  • Author(s): Kamijo N, Matsumoto A, Umemura T, Shibata S, Ichikawa, Y, Kimura T, Komatsu M, Tanaka E
  • Journal Title: World J Gastroenterol Volume: 21 Issue: 2 Pages: 541-548
  • DOI: 10.3748/wjg.v21.i2.541
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Characteristics and prediction of hepatitis B e-antigen negative hepatitis following seroconversion in patients with chronic hepatitis B (2014)
  • Author(s): Morita S, Matsumoto A, Umemura T, Shibata S, Kamijo N, Ichikawa Y, Kimura T, Joshita S, Komatsu M, Yoshizawa K, Tanaka E
  • Journal Title: Hepatol Res Volume: 印刷中 Issue: 10
  • DOI: 10.1111/hepr.12208
  • Peer Reviewed
• [Journal Article] Guidelines for avoiding risks resulting from discontinuation of nucleoside/nucleotide analogs in patients with chronic hepatitis B (2014)
  • Author(s): Tanaka E, Matsumoto A
  • Journal Title: Hepatol Res Volume: 44 Issue: 1 Pages: 1-8
  • DOI: 10.1111/hepr.12108
  • NAID: 120007110572
  • Peer Reviewed
• [Journal Article] Impact of Combination Therapy with Peginterferon alpha-2b and Entecavir on Persistent Viral Suppression in Patients with Chronic Hepatitis B. (2013)
  • Author(s): Hagiwara S, Kudo M, Osaki Y, Matsuo H, Inuzuka T, Matsumoto A, Tanaka E, Sakurai, Ueshima K, Inoue T, Yada N, Nishida N
  • Journal Title: J Med Virol. Volume: 85 Issue: 6 Pages: 987-995
  • DOI: 10.1002/jmv.23564
  • Peer Reviewed
• [Presentation] Mutations of pre-core and BCP before and after HBeAg seroconversion. (2014)
  • Author(s): Kamijo N, Matsumoto A, Umemura T, Shibata S, Ichikawa Y, Kimura T, Komatsu M, Tanaka E
  • Organizer: The 11th JSH Single Topic Conference, Hepatitis B - Recent Progress in Basic and Clinical Research
  • Place of Presentation: Hotel Granvia Hiroshima, Hiroshima, Japan
  • Year and Date: 2014-11-20 – 2014-11-21
• [Presentation] 高感度HBV RNA定量系によるB型慢性肝炎核酸アナログ治療例の病態解析 (2013)
  • Author(s): 松本晶博、森田進、田中榮司
  • Organizer: 第49回日本肝臓学会総会
  • Place of Presentation: 京王プラザホテル（東京都新宿区）