| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
In this study, we elucidated that Protein S (PS) exacerbates steatohepatitis by stimulating natural killer T and inhibiting apoptosis of the cell type. Atherosclerosis caused by ethanol is associated with activation of the coagulation system and decreased circulating levels of stromal cell-derived factor-1. These data collectively indicate that derangement of the coagulation and fibrinolysis system contributes to pathogenesis of not only steatohepatitis but atherosclerosis. This suggests that the coagulation and fibrinolysis system is a new therapeutic target for steatohepatistis and its complication, atherosclerosis.
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