Elucidation of the common mechanisms of tissue remodeling in nonalcoholic steatohapatitis
Project/Area Number |
25460990
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | Mie University |
Principal Investigator |
Takei Yoshiyuki 三重大学, 医学(系)研究科(研究院), 教授 (10306954)
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Co-Investigator(Kenkyū-buntansha) |
GABAZZA Esteban 三重大学, 医学(系)研究科(研究院), 教授 (00293770)
IWASA Motoh 三重大学, 医学(系)研究科(研究院), 准教授 (80378299)
FUJITA Naoki 三重大学, 医学(系)研究科(研究院), リサーチアソシエイト (80378398)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 脂肪性肝炎 / 動脈硬化症 / 凝固・線溶系 / 組織リモデリング / protein S |
Outline of Final Research Achievements |
In this study, we elucidated that Protein S (PS) exacerbates steatohepatitis by stimulating natural killer T and inhibiting apoptosis of the cell type. Atherosclerosis caused by ethanol is associated with activation of the coagulation system and decreased circulating levels of stromal cell-derived factor-1. These data collectively indicate that derangement of the coagulation and fibrinolysis system contributes to pathogenesis of not only steatohepatitis but atherosclerosis. This suggests that the coagulation and fibrinolysis system is a new therapeutic target for steatohepatistis and its complication, atherosclerosis.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] Protein S exacerbates alcoholic hepatitis by stimulating liver natural killer T cells.2015
Author(s)
Chelakkot-Govindalayathil AL, Mifuji-Moroka R, D'Alessandro-Gabazza CN, Toda M, Matsuda Y, Gil-Bernabe P, Roeen Z, Yasuma T, Yano Y, Gabazza EC, Iwasa M, Takei Y.
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Journal Title
J Thromb Haemost.
Volume: 13(1)
Issue: 1
Pages: 142-154
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Evaluation and prognosis of sarcopenia using impedance analysis in patients with liver cirrhosis.2014
Author(s)
Iwasa M, Hara N, Terasaka E, Hattori A, Ishidome M, Mifuji-Moroka R, Miyachi H, Sugimoto R, Tanaka H, Fujita N, Kobayashi Y, Iwata K, Takei Y.
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Journal Title
Hepatol Res
Volume: 44
Issue: 10
DOI
Related Report
Peer Reviewed
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[Journal Article] Nutrition therapy using a multidisciplinary team improves survival rates in patients with liver cirrhosis.2013
Author(s)
Iwasa M, Iwata K, Hara N, Hattori A, Ishidome M, Sekoguchi-Fujikawa N, Mifuji-Moroka R, Sugimoto R, Fujita N, Kobayashi Y, Takei Y
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Journal Title
Nutrition
Volume: 29
Issue: 11-12
Pages: 1418-1421
DOI
Related Report
Peer Reviewed
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[Presentation] 鉄代謝障害と肝疾患2015
Author(s)
竹井謙之
Organizer
第39回日本鉄バイオサイエンス学会学術集会
Place of Presentation
岡山コンベンションセンター (岡山市)
Year and Date
2015-08-29
Related Report
Invited
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