Project/Area Number |
25460998
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Gastroenterology
|
Research Institution | Kagawa University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
TANI Joji 香川大学, 医学部, 助教 (00596075)
HIMOTO Takashi 香川県立保健医療大学, 保健医療学部, 教授 (20325343)
MIYOSHI Hisaaki 香川大学, 医学部附属病院, 助教 (40592316)
HIRASHIMA Mitsuomi 香川大学, 医学部, 研究員 (70109700)
YONEYAMA Hirohito 香川大学, 医学部附属病院, 助教 (80294750)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | Hepatocellular carcinoma / Gal-9 / microRNA / Cancer / 肝細胞癌 / 膵癌 / 胆のう癌 / 胃癌 / マイクロRNA / アポトーシス / 細胞周期 / 細胞がん / マイクロRNA / 肝癌 / ガレクチン9 |
Outline of Final Research Achievements |
Anti-tumor effects of galectin-9 was detected in hepatocellular carcinoma cell induced the strong apoptosis through microRNA in vitro and in vivo(Int J Oncol. 2015 Jun;46(6):2419-30) In addition, the antitumor effect of galectin-9 was also detected in cholangiocarcinoma (Oncol Rep. 2015 Oct; 34 (4): 1761-70), gastric cancer (Oncol Rep. 2016 Feb; 35 (2): 851-60), gallbladder cancer(Int J Oncol. 2016 Mar; 48 (3): 1165-74).
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