Anti-tumor effect of galectin 9 in hepatocell carcinoma:Basic study

• Project/Area Number: 25460998
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Kagawa University
• Principal Investigator: masaki tsutomu 香川大学, 医学部, 教授 (30335848)
• Co-Investigator(Kenkyū-buntansha): TANI Joji 香川大学, 医学部, 助教 (00596075) ; HIMOTO Takashi 香川県立保健医療大学, 保健医療学部, 教授 (20325343) ; MIYOSHI Hisaaki 香川大学, 医学部附属病院, 助教 (40592316) ; HIRASHIMA Mitsuomi 香川大学, 医学部, 研究員 (70109700) ; YONEYAMA Hirohito 香川大学, 医学部附属病院, 助教 (80294750)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: Hepatocellular carcinoma / Gal-9 / microRNA / Cancer / 肝細胞癌 / 膵癌 / 胆のう癌 / 胃癌 / マイクロＲＮＡ / アポトーシス / 細胞周期 / 細胞がん / マイクロRNA / 肝癌 / ガレクチン9

Outline of Final Research Achievements

Anti-tumor effects of galectin-9 was detected in hepatocellular carcinoma cell induced the strong apoptosis through microRNA in vitro and in vivo（Int J Oncol. 2015 Jun;46(6):2419-30） In addition, the antitumor effect of galectin-9 was also detected in cholangiocarcinoma (Oncol Rep. 2015 Oct; 34 (4): 1761-70), gastric cancer (Oncol Rep. 2016 Feb; 35 (2): 851-60), gallbladder cancer(Int J Oncol. 2016 Mar; 48 (3): 1165-74).

Research Products

• [Journal Article] Galectin-9: An anticancer molecule for gallbladder carcinoma (2016)
  • Author(s): Tadokoro T, Morishita A, Fujihara S, Iwama H, Niki T, Fujita K, Akashi E, Mimura S, Oura K, Sakamoto T, Nomura T, Tani J, Miyoshi H, Yoneyama H, Himoto T, Hirashima M, Masaki T
  • Journal Title: Int J Oncol Volume: 48 Pages: 1165-1174
  • Peer Reviewed
• [Journal Article] Galectin-9 suppresses the proliferation of gastric cancer cells in vitro (2016)
  • Author(s): Takano J, Morishita A, Fujihara S, Iwama H, Kokado F, Fujikawa K, Fujita K, Chiyo T, Tadokoro T, Sakamoto T, Nomura T, Tani J, Miyoshi H, Yoneyama H, Kobara H, Mori H, Niki T, Hirashima M, Masaki T
  • Journal Title: Oncol Rep Volume: 35 Pages: 851-860
  • Peer Reviewed / Open Access
• [Journal Article] Galectin-9 suppresses cholangiocarcinoma cell proliferation by inducing apoptosis but not cell cycle arrest. (2015)
  • Author(s): Kobayashi K, Morishita A, Iwama H, Fujita K, Okura R, Fujihara S, Yamashita T, Fujimori T, Kato K, Kamada H, Niki T, Hirashima M, Okano K, Suzuki Y, Masaki T.
  • Journal Title: Oncol Rep Volume: 34 Pages: 1761-1770
  • Peer Reviewed / Open Access
• [Journal Article] Galectin-9 suppresses the growth of hepatocellular carcinoma via apoptosis in vitro and in vivo (2015)
  • Author(s): Fujita K, Iwama H, Sakamoto T, Okura R, Kobayashi K, Takano J, Katsura A, Tatsuta M, Maeda E, Mimura S, Nomura T, Tani J, Miyoshi H, Morishita A, Yoneyama H, Yamana Y, Himoto T, Okano K, Suzuki Y, Niki T, Hirashima M, Masaki T
  • Journal Title: Int J Oncol Volume: 46 Pages: 2419-2430
  • Peer Reviewed / Open Access
• [Journal Article] Galectin-9 suppresses the growth of hepatocellular carcinoma via apoptosis in vitro and in vivo. (2015)
  • Author(s): Fujita K, Iwama H, Sakamoto T, Okura R, Kobayashi K, Takano J, Katsura A, Tatsuta M, Maeda E, Mimura S, Nomura T, Tani J, Miyoshi H, Morishita A, Yoneyama H, Yamana Y, Himoto T, Okano K, Suzuki Y, Niki T, Hirashima M, Masaki T.
  • Journal Title: Int J Oncol. Volume: 46 Issue: 6 Pages: 2419-2430
  • DOI: 10.3892/ijo.2015.2941
  • Peer Reviewed
• [Journal Article] Galectin-9 prolongs the survival of septic mice by expanding Tim-3-expressing natural killer T cells and PDCA-1+ CD11c+ macrophages (2013)
  • Author(s): Kadowaki T, Morishita A, Niki T, Hara J, Sato M, Tani J, Miyoshi H, Yoneyama H, Masaki T, Hattori T, Matsukawa A, Hirashima M.
  • Journal Title: Crit Care Volume: 17(6) Issue: 6
  • DOI: 10.1186/cc13147
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 肝臓における代謝・炎症・発癌について (2015)
  • Author(s): 藤田浩二、大浦杏子、正木 勉
  • Organizer: 第41回日本肝臓学会西部会
  • Place of Presentation: 名古屋市
  • Year and Date: 2015-12-03
• [Presentation] 肝細胞癌の腫瘍マーカーとしての血清ガレクチン-9 濃度の検討 (2015)
  • Author(s): 藤田浩二、坂本鉄平、正木 勉
  • Organizer: 第51回日本肝臓学会総会
  • Place of Presentation: 熊本市
  • Year and Date: 2015-05-22
• [Presentation] 劇症肝炎におけるガレクチン-9の有効性について (2015)
  • Author(s): 田所智子、森下朝洋、米山弘人、三好久昭、谷 丈二、野村貴子、坂本鉄平、藤田浩二、三村志麻、明石瑛美子、大浦杏子、正木 勉
  • Organizer: 第51回日本肝臓学会総会
  • Place of Presentation: 熊本市
  • Year and Date: 2015-05-22
• [Presentation] 胆管細胞癌におけるガレクチン-9 による増殖抑制効果の検討 (2015)
  • Author(s): 小林聖幸、藤田浩二、大倉亮一、山下拓磨、西岡智子、谷 丈二、三好久昭、坂本鉄平、藤森崇行、加藤清仁、鎌田英紀、森下朝洋、米山弘人、正木 勉
  • Organizer: 第51回日本肝臓学会総会
  • Place of Presentation: 熊本市
  • Year and Date: 2015-05-21